Does isotretinoin cause depression and anxiety in acne patients?

Metekoğlu, Şafak; Oral, Elif; Ucar, Cagla; Akalın, Mehmet Ali

doi:10.1111/dth.12795

Cited by 16 publications

(18 citation statements)

References 36 publications

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“…In line with Yazici K. et al (2004) the severity of disease is not related to depression in acne patients [8]. Furthermore, no any significant correlation was reported between depression with gender, quality of life, and isotretinoin therapy [38, 39]. Poor AIS score, lower serum levels of BDNF, dropping out of school, currently unemployed, and lower family annual income were independent risk factors for depressive symptoms after adjustment by variables [39].…”

Section: Discussionsupporting

confidence: 60%

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

Tian

Deng

et al. 2019

BMC Psychiatry

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Background: Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris. The study aimed to determine the potential association between BDNF and depressive symptoms in young adults with acne vulgaris. Methods: In this analytical cross-sectional study, the serum BDNF levels were measured in peripheral blood samples of 20 consecutive acne vulgaris patients with depression and 98 consecutive acne vulgaris patients without depression and also compared it with a 59 healthy control group by using a ELISA. The potential correlation between the BDNF levels, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and depressive symptoms such as nine-item patient health questionnaire (PHQ-9) and Athens insomnia scale (AIS) were evaluated with multivariate logistic regression analysis. Results: Our results showed that levels of BDNF expression were lower in consecutive acne vulgaris patients when compared with healthy control (P < 0.05). There was a negative correlation between levels of BDNF and the PHQ-9 scores (r = − 0.486, P < 0.001). Furthermore, acne vulgaris patients with depression showed lower serum BDNF levels (10.96 ± 2.12 ng/ml) compared with acne vulgaris patients without depression (13.85 ± 2.47 ng/ml), as well as with healthy control (14.35 ± 2.70 ng/mg; both P < 0.05). No difference was found in serum BDNF levels between healthy control and acne vulgaris patients without depressive symptoms (z = 0.964, P > 0.05). Similarly, the overall area under the curve of receiver operating characteristic was 0.82, indicating the highly conserving of serum BDNF levels as an biomarker for screening of depression in young adults with acne vulgaris (72% sensitivity and 85% specificity). Conclusion: Serum BDNF levels were decreased and negatively associated with depressive symptoms in young Chinese adults with acne vulgaris.

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Section: Discussionsupporting

confidence: 60%

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

Tian

Deng

et al. 2019

BMC Psychiatry

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“…In a few reports it was not clear which statistical test was used. Two studies used an incorrect score range 52,53 and another reported data outside the possible range. 21 We have previously highlighted this lack of quality assurance in the use and reporting of QoL studies [97][98][99][100] and recommend the implementation of formal guidelines and tighter requirements for publishing QoL data.…”

Section: Discussionmentioning

confidence: 99%

Clinical experience and psychometric properties of the Cardiff Acne Disability Index (CADI)*

et al. 2021

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The Cardiff Acne Disability Index (CADI) is a questionnaire designed to measure the quality of life of teenagers and young adults with acne. It has been used clinically and within therapeutic research globally. This review aims to appraise all published data regarding the clinical and research experience of the CADI, its psychometric properties and validation, from its publication in 1992 until September 2020, in a single reference source. A literature search was conducted using MEDLINE via Ovid, PubMed, EBSCOhost, Web of Science and Scopus. All full articles in the English language were included. A total of 96 clinical studies were identified and analysed. The CADI has been used in 44 different countries, including four multinational studies, and has validated translations in 25 languages. Overall, 29 therapeutic interventions have used the CADI, demonstrating its responsiveness to change. The reliability of the CADI has been assessed in 14 studies through test-retest and internal consistency studies. In total, 57 studies have demonstrated aspects of its validity through correlation to other measures, and five studies have investigated the dimensionality of the CADI. There is evidence of high internal consistency, test-retest reliability, responsiveness to change and significant correlation with other objective measures. The minimal clinically important difference and validated score meaning bands have not yet been reported. This information is needed to improve the interpretability of CADI scores for clinical use and in research. The authors of the CADI have also rephrased Question 2 of the measure to ensure inclusivity.What is already known about this topic?• Acne significantly impacts quality of life in patients.• There are several skin-specific and acne-specific instruments used in day-to-day practice and research.• The validation and other measurement properties of the Cardiff Acne Disability Index (CADI) have not been easily accessible.What does this study add?• The CADI has been extensively used and is a reliable and valid tool.• There is a need to develop validated CADI score bands and calculate the minimal clinically important difference.• The CADI authors have rephrased Question 2 to ensure that the wording is inclusive.• There is inconsistent reporting of CADI data and a need for guidelines when reporting and publishing quality-of-life data.

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“…However, no relationship was found in prospective studies between isotretinoin and depression and even an improvement in depression scores was observed. 26…”

Section: Acne and Depressionmentioning

confidence: 99%

Psychodermatology of acne: Dermatologist's guide to inner side of acne and management approach

Kayıran

Karadağ

Jafferany

2020

Dermatologic Therapy

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Acne vulgaris (AV) is a skin disease that is commonly seen and causes scar formation especially when left untreated. It can cause serious psychological comorbidities due to the intense involvement of appeared areas such as face and also being common in adolescence in which the body perception is not yet well established. Although psychiatric comorbidities frequently accompany AV patients in dermatology, they almost never directed to dermatology-psychiatry liaison clinics. Depression, anxiety, stress, decreased self-esteem, suicidal thoughts and even suicide attempts are too frequent to ignore in these patients, and many studies have been conducted on the positive or controversial effects of acne treatments. For this reason, serious responsibilities fall to dermatologists. They should not treat AV lesions only, but also to determine the AV patients' psychological conditions and to direct them to get help when necessary.

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Does isotretinoin cause depression and anxiety in acne patients?

Cited by 16 publications

References 36 publications

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

Clinical experience and psychometric properties of the Cardiff Acne Disability Index (CADI)*

Psychodermatology of acne: Dermatologist's guide to inner side of acne and management approach

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