Does Ketamine Have a Role in Managing Severe Exacerbation of Asthma in Adults?

Lau, Tim T Y; Zed, Peter J.

doi:10.1592/phco.21.13.1100.34618

Cited by 39 publications

(2 citation statements)

References 16 publications

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“…Ketamine and thiopental in anesthetic and subanesthetic doses increased the amount of MDA and decreased the levels of tGSH, GSHRd, and GPO in the bronchial tissues as in the striatum and heart tissues, suggesting that both drugs caused oxidative stress in the bronchi. It has been reported in the literature that ketamine exerts a bronchodilatory effect by increasing adrenaline, while thiopental produces a bronchoconstrictor effect by decreasing adrenaline [ 14 , 45 ]. Furthermore, adrenaline has been reported to inhibit the release of NO [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

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The effects of ketamine and thiopental used alone or in combination on the brain, heart, and bronchial tissues of rats

Ahıskalıoğlu¹,

Aydin²,

Ahıskalıoğlu³

et al. 2018

aoms

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IntroductionWe compared the side effects of ketamine and thiopental used alone and of a ketamine/thiopental combination dose on the brain,heart, and bronchial tissues of rats.Material and methodsThree groups received intraperitoneal injections of 30 mg/kg ketamine (K-30); 15 mg/kg thiopental (T-15); or of both in combination (KTSA). These doses were doubled in another set of study groups (K-60, T-30, and KTA groups, respectively). Optimal anesthesia duration was examined in all groups.ResultsAnesthesia did not occur with 30 mg/kg ketamine or 15 mg/kg thiopental. However, when used alone ketamine and thiopental led to oxidative stress in the striatum, heart, and bronchial tissues. Conversely, combined administration of anesthetics and subanesthetic doses were found not to create oxidative stress in any of these areas. The highest level of adrenaline in blood samples collected from the tail veins was measured in the KTA-60, and the lowest amount in the T-30. Creatine kinase activity was highest in the KTA-60 group (p < 0.001). When we compared for all 5 groups to untreated control group; the creatine kinase-MB activities were significiantly different in K-30, T-15 and T-30 (p < 0.001).ConclusionsThe studied doses of ketamine led to oxidative stress by increasing the amount of adrenaline. Thiopental increased oxidative stress with decreases in adrenaline. A longer anesthetic effect with minimal adverse events may be achieved by ketamine and thiopental in combination.

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Section: Discussionmentioning

confidence: 99%

“…The side effects of ketamine on the heart and vessels are thought to result from its sympathomimetic activity [ 13 ]. With respect to the impact on the bronchial tissues, ketamine has been reported to cause bronchodilation via the discharge of catecholamine through the central pathway [ 14 ].…”

Section: Introductionmentioning

confidence: 99%