Does local delivery of bisphosphonates influence the osseointegration of titanium implants? A systematic review

Guimarães, Magáli Beck; Antes, T.H.; Dolacio, M.B.; Pereira, Diego de Medeiros; Marquezan, Mariana

doi:10.1016/j.ijom.2017.04.014

Cited by 21 publications

(13 citation statements)

References 34 publications

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“…These findings are further supported by a preclinical study demonstrating an enhancement of peri-implant bone density and an increased mechanical fixation of bisphosphonate-coated dental implants in the rat model [51]. Moreover, our results are also in agreement with clinical studies that report an improvement of osseointegration parameters, better implant stability, and reduced peri-implant bone loss after local bisphosphonates application [52,53]. According to the present findings, studies included for meta-analysis that investigated alendronate or pamidronate coating of titanium surfaces increased ALP activity in osteoblasts.…”

Section: Discussionsupporting

confidence: 91%

Effect of bisphosphonate treatment of titanium surfaces on alkaline phosphatase activity in osteoblasts: a systematic review and meta-analysis

et al. 2020

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Background: Bisphosphonate coating of dental implants is a promising tool for surface modification aiming to improve the osseointegration process and clinical outcome. The biological effects of bisphosphonates are thought to be mainly associated with osteoclasts inhibition, whereas their effects on osteoblast function are unclear. A potential of bisphosphonate coated surfaces to stimulate osteoblast differentiation was investigated by several in vitro studies with contradictory results. The purpose of this systematic review and meta-analysis was to evaluate the effect of bisphosphonate coated implant surfaces on alkaline phosphatase activity in osteoblasts. Methods: In vitro studies that assessed alkaline phosphatase activity in osteoblasts following cell culture on bisphosphonate coated titanium surfaces were searched in electronic databases PubMed/MEDLINE, Scopus and ISI Web of Science. Animal studies and clinical trials were excluded. The literature search was restricted to articles written in English and published up to August 2019. Publication bias was assessed by the construction of funnel plots. Results: Eleven studies met the inclusion criteria. Meta-analysis showed that coating of titanium surfaces with bisphosphonates increases alkaline phosphatase activity in osteoblasts after 3 days (n = 1), 7 (n = 7), 14 (n = 6) and 21 (n = 3) days. (7 days beta coefficient = 1.363, p-value = 0.001; 14 days beta coefficient = 1.325, p-value < 0.001; 21 days beta coefficient = 1.152, p-value = 0.159). Conclusions: The meta-analysis suggests that bisphosphonate coatings of titanium implant surfaces may have beneficial effects on osteogenic behaviour of osteoblasts grown on titanium surfaces in vitro. Further studies are required to assess to which extent bisphosphonates coating might improve osseointegration in clinical situations.

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Section: Discussionsupporting

confidence: 91%

Effect of bisphosphonate treatment of titanium surfaces on alkaline phosphatase activity in osteoblasts: a systematic review and meta-analysis

et al. 2020

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“…The use of bisphosphonates as an adjuvant for osseointegration has been studied by the use in systemic treatments [20,21] and locally [22][23][24][25], acting as biomodulators of bone remodeling, with the action associated to the inhibition of osteoclasts. The chemical aspects associated with the interactions between the drug and the bone have already been studied in detail [23], further demonstrating the binding affinity of bisphosphates and the mineral part of the bone.…”

Section: Introductionmentioning

confidence: 99%

Bisphosphonate-based surface biofunctionalization improves titanium biocompatibility

Albano

Gomes

Feltran

et al. 2020

J Mater Sci: Mater Med

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Novel-biofunctionalized surfaces are required to improve the performance of endosseous implants, which are mainly related to the resistance against biocorrosion, as well as for the consideration of osteoinductive phenomena. Among different strategies, the use of bisphosphonate molecules as linkers between titanium dioxide (TiO 2) surfaces and proteins is a distinctive approach, one in which bisphosphonate could play a role in the osseointegration. Thus, to address this issue, we proposed a novel biofunctionalization of TiO 2 surfaces using sodium alendronate (ALN) as a linker and bovine serum albumin as the protein. Physicochemical analysis of the functionalized surfaces was performed using contact angle analyses and surface roughness measurements, which indicated an efficient functionalization. The biocompatibility of the functionalized surfaces was analyzed through the adhesion behavior of the pre-osteoblasts onto the samples. Overall, our data showed a significant improvement concerning the cell adhesion by modulating the adhesion cell-related set of genes. The obtained results show that for modified surfaces there is an increase of up to 100 times in the percentage of cells adhered when compared to the control, besides the extracellular matrix remodeling seemed to be an essential prerequisite for the early stages of cell adhesion on to the biomaterials, which was assayed by evaluating the matrix metalloproteinase activities as well as the gene activations. In the expressions of the Bsp and Bglap2 genes, for the group containing ALN (TiO 2 + ALN), it was observed an increase in expression (approximately sixfold change) when compared to the control. Altogether, our data clearly showed that the bisphosphonate-biofunctionalized surface enhanced the biocompatibility of titanium and claims to further progress preclinical in vivo experimentation.

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“…The reasons for excluding studies after full-text assessment were as follows: non-human studies (n = 5) [8][9][10][11][12], in vitro studies (n = 2) [13][14], systematic reviews (n = 16) [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Exclusion Of Studiesmentioning

confidence: 99%

Dental implant placement in patients on bisphosphonate therapy: a systematic review

2018

Br Dent J

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Objectives: The review aims to study dental implant placement purposefulness for patients who have been treated or are on treatment with bisphosphonate medication. Material and Methods: Structured search strategy was applied on electronic databases: MEDLINE, PubMed, PubMed Central and ResearchGate. Scientific publications in English between 2006 and 2017 were identified in accordance with inclusion, exclusion criteria. Publication screening, data extraction, and quality assessment were performed. Outcome measures included implant failure or implant-related osteonecrosis of the jaw. Results: In total, 32 literature sources were reviewed, and 9 of the most relevant articles that are suitable to the criteria were selected. Heterogeneity between the studies was found and no meta-analysis could be done. Five studies analysed intraoral bisphosphonate medication in relation with implant placement, three studies investigated intravenous bisphosphonate medication in relation with implant placement and one study evaluated both types of medication given in relation with implant placement. Patients with intraoral therapy appeared to have a better implant survival (5 implants failed out of 423) rate at 98.8% vs. patients treated intravenously (6 implants failed out of 68) at 91%; the control group compared with intraoral bisphosphonate group appeared with 97% success implant survival rate (27 implants failed out of 842), showing no significant difference in terms of success in implant placement. Conclusions: Patients treated with intravenous bisphosphonates seemed to have a higher chance of developing implantrelated osteonecrosis of the jaw. The intraorally treated patient group appeared to have more successful results. Implant placement in patients treated intraorally could be considered safe with precautions.

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Does local delivery of bisphosphonates influence the osseointegration of titanium implants? A systematic review

Cited by 21 publications

References 34 publications

Effect of bisphosphonate treatment of titanium surfaces on alkaline phosphatase activity in osteoblasts: a systematic review and meta-analysis

Effect of bisphosphonate treatment of titanium surfaces on alkaline phosphatase activity in osteoblasts: a systematic review and meta-analysis

Bisphosphonate-based surface biofunctionalization improves titanium biocompatibility

Dental implant placement in patients on bisphosphonate therapy: a systematic review

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