Does low BMI affect ART outcomes?

Oliveira, J.B.A.

doi:10.5935/1518-0557.20180021

Cited by 3 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with the present data, the percentages of Japanese women in their 20s with a BMI <18.5 kg/m 2 were 13.5% in 1979, 20.4% in 1998, 22.3% in 2009, 21.5% in 2013, 20.7% in 2016, and 20.7% in 2019 [16-20]. An underweight BMI <18.5 kg/m 2 is associated with lower fertility [21,22], and a low BMI is associated with a lower probability of a woman becoming pregnant, a higher risk of miscarriage, and a lower probability of live birth [23]. A low BMI is also associated with anemia, low sex hormone concentrations, low bone density, hypotension, and feelings of fatigue and malaise [1].…”

Section: Discussionsupporting

confidence: 86%

Differing Effects of Body Size on Circulating Lipid Concentrations and Hemoglobin A1c Levels in Young and Middle-Aged Japanese Women

Iizuka,

Kobae,

Yanagi

et al. 2024

Healthcare

View full text Add to dashboard Cite

The condition of being underweight is a social problem in Japan among women. However, there is a lack of evidence for dietary guidance for underweight women because there has been no comparison of lipids or HbA1c among underweight, normal weight, and overweight women in different age groups. We analyzed the effect of body size and age on the serum lipid and hemoglobin A1c levels in Japanese women in a cross-sectional study. A total of 26,118 women aged >20–65 years underwent physical examinations between 2012 and 2022. Seventeen percent of women aged >20–29 years were underweight, and 8% of those aged 50–65 years were underweight. Total cholesterol and non-HDL-C concentrations increased with age, but the difference between underweight and overweight individuals was lowest among women aged 50–65 years. On the other hand, the differences in HDL-C, TG, and HbA1c levels between underweight and overweight subjects were greatest in the 50–65 age group, but the differences between underweight and normal weight subjects were much smaller. Considering that, unlike HDL-C, TG, and HbA1c, TC and non-HDL-C increase to levels comparable to overweight levels in underweight women in aged 50–65 years, educating people about a diet that lowers non-HDL-C is necessary even in young underweight women.

show abstract

Section: Discussionsupporting

confidence: 86%

Differing Effects of Body Size on Circulating Lipid Concentrations and Hemoglobin A1c Levels in Young and Middle-Aged Japanese Women

Iizuka,

Kobae,

Yanagi

et al. 2024

Healthcare

View full text Add to dashboard Cite

show abstract

“…anorexia athletica) or low muscle mass, muscular atrophy [ 42 ], cardiovascular abnormalities, valvular dysfunction, compromised immunity [ 43 ]; cancer —particularly poor outcomes of some cancers, potentially decreased tolerability/effectiveness of cancer treatment e.g. due to lower haemoglobin and albumin resulting from abnormal nutritional status, cachexia, impaired anti-tumour immunity [ 44 ], loss of muscle fat mass, sarcopenia [ 45 ], increased risk of several cancer types and metastatic disease [ 6 , 46 , 47 ]; impaired healing and increased post-surgical complications —abnormal nutritional status, insufficient energy supply, shifted metabolic pathways and microbiome alterations [ 4 , 24 , 48 ], potentially low preoperative haemoglobin [ 49 , 50 ]; reproductive dysfunction —disruption of hypothalamic-pituitary–gonadal axis leading to hypothalamic anovulation [ 51 ], ovulatory dysfunction [ 52 ], negative effects on IVF parameters [ 53 – 55 ]; compromised immunity —abnormal nutritional status, lymphopenia [ 56 ]; respiratory infections including COVID-19 —malnutrition [ 57 ], coexisting chronic conditions [ 58 ], immuno-suppression as a result of malnutrition [ 59 ]; eating disorders (anorexia nervosa) —negative effects on overall and reproductive health [ 60 ]; neurological disorders such as young stroke [ 12 ] and abnormal pain sensitivity / perception [ 4 , 7 ]; abnormal sleep patterns [ 7 , 11 , 15 ] and depression [ 61 ]; primary vascular dysregulation —abnormal nutrition, low energy supply, Flammer syndrome, high Endothelin-1 level in blood plasma, increased stress sensitivity, amongst others [ 4 , 9 , 15 , 17 , 62 ]; Sicca syndrome with severe complications [ 11 , 13 , 15 ]. …”

Section: Systemic Effects and Health Risks Associated With Low Body Weightmentioning

confidence: 99%

“…There is a significant association between BMI and reproductive health [ 90 ]. Infertility problems and unfavourable outcomes in pregnancy are reported in women with low weight [ 53 ]. Anovulatory infertility was associated with underweight.…”

Section: Reproductive Dysfunction and Pregnancymentioning

confidence: 99%

Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

et al. 2021

View full text Add to dashboard Cite

An increasing interest in a healthy lifestyle raises questions about optimal body weight. Evidently, it should be clearly discriminated between the standardised “normal” body weight and individually optimal weight. To this end, the basic principle of personalised medicine “one size does not fit all” has to be applied. Contextually, “normal” but e.g. borderline body mass index might be optimal for one person but apparently suboptimal for another one strongly depending on the individual genetic predisposition, geographic origin, cultural and nutritional habits and relevant lifestyle parameters—all included into comprehensive individual patient profile. Even if only slightly deviant, both overweight and underweight are acknowledged risk factors for a shifted metabolism which, if being not optimised, may strongly contribute to the development and progression of severe pathologies. Development of innovative screening programmes is essential to promote population health by application of health risks assessment, individualised patient profiling and multi-parametric analysis, further used for cost-effective targeted prevention and treatments tailored to the person. The following healthcare areas are considered to be potentially strongly benefiting from the above proposed measures: suboptimal health conditions, sports medicine, stress overload and associated complications, planned pregnancies, periodontal health and dentistry, sleep medicine, eye health and disorders, inflammatory disorders, healing and pain management, metabolic disorders, cardiovascular disease, cancers, psychiatric and neurologic disorders, stroke of known and unknown aetiology, improved individual and population outcomes under pandemic conditions such as COVID-19. In a long-term way, a significantly improved healthcare economy is one of benefits of the proposed paradigm shift from reactive to Predictive, Preventive and Personalised Medicine (PPPM/3PM). A tight collaboration between all stakeholders including scientific community, healthcare givers, patient organisations, policy-makers and educators is essential for the smooth implementation of 3PM concepts in daily practice.

show abstract

“…Furthermore, the previous studies on the effects of underweight on ART outcomes were more focused on the rates of live birth and miscarriage than birth weight (Singh et al, 2012;Provost et al, 2016;Wang et al, 2000;Wittemer et al, 2000;Oliveira et al, 2018;Cai et al, 2017;Veleva et al, 2008). Therefore, very few studies have examined the relationship of underweight mothers with perinatal outcomes in singleton infants who are conceived with ART.…”

Section: Discussionmentioning

confidence: 99%

A propensity-matched study of the association between pre-pregnancy maternal underweight and perinatal outcomes of singletons conceived through assisted reproductive technology

Liu

Zhao

et al. 2019

Reproductive BioMedicine Online

View full text Add to dashboard Cite

show abstract

Does low BMI affect ART outcomes?

Cited by 3 publications

References 11 publications

Differing Effects of Body Size on Circulating Lipid Concentrations and Hemoglobin A1c Levels in Young and Middle-Aged Japanese Women

Differing Effects of Body Size on Circulating Lipid Concentrations and Hemoglobin A1c Levels in Young and Middle-Aged Japanese Women

Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

A propensity-matched study of the association between pre-pregnancy maternal underweight and perinatal outcomes of singletons conceived through assisted reproductive technology

Contact Info

Product

Resources

About