Does lycopene offer human LDL any protection against myeloperoxidase activity?

Chew, Poh Yeong; Riley, Lucy; Graham, Daniel L.; Rahman, Khalid; Lowe, Gordoǹ

doi:10.1007/s11010-011-1102-0

“…In vitro studies indicated that pure lycopene is degraded by the activity of MPO. There is a depletion of (all-E)-lycopene, along with the formation of many oxidation products including (Z)-isomers, epoxides and shorter chain derivatives of lycopene including apo-lycopenals (Chew et al, 2012;Pennathur et al, 2010). When isolated human LDL is challenged by MPO, there is an oxidation of apoB100 followed by lipoperoxidation.…”

Section: Myeloperoxidasementioning

confidence: 99%

“…In a recent study, no alteration in lycopene concentration, but oxidation of apoB100 and the formation of 7-ketocholesterol were observed. This would indicate that the surface of the LDL particle is more prone to modification following MPO activity and that lycopene has only a very minor if any role as an antioxidant (Chew et al, 2012).…”

Section: Myeloperoxidasementioning

confidence: 99%

A Review on Potential Properties and Therapeutic Applications of Lycopene

Kwatra¹

2020

IJMBS

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The present review is based mainly on papers published between 2000 and 2011 and gives information about the properties of the carotenoid lycopene in chemical and biological systems and its possible role in preventing cardiovascular diseases (CVD). The main aim of this report is to highlight its role as an antioxidant, also reported are bioactive properties that may influence the development of foam cells and protection against endothelial cell damage. The paper will also examine recent observations that lycopene may improve blood flow and reduce inflammatory responses. Lycopene possesses antioxidant properties in vitro, and some epidemiological studies have reported protective effects against the progression of CVD. The oxidation of human low density lipoproteins (LDL) is a fundamental mechanism in the initiation of atherosclerosis. A beneficial role of lycopene as antioxidant in the prevention of CVD is suggested but the data are still controversial. Lycopene is believed to be the most potent carotenoid antioxidant in vitro. Tissue culture experiments and animal studies support potential cardioprotective effects for lycopene and other carotenoids in the blood. Most studies showed beneficial effects of lycopene to individuals who are antioxidant-deficient like elderly patients, or humans exposed to higher levels of oxidative stress like smokers, diabetics, hemodialysis patients and acute myocardial infarction patients. By defining the right population and combining antioxidant potentials of lycopene with vitamins and other bioactive plant compounds, the beneficial role of lycopene in CVD can be clarified in future studies. Keywords: Atherosclerosis, isomerization, in vitro, in vivo, LDL oxidatin

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“…There is a depletion of (all-E)-lycopene, along with the formation of many oxidation products including (Z)-isomers, epoxides and shorter chain derivatives of lycopene including lycopenals and lycopenoids (Chew et al, 2012;Pennathur et al, 2010). When isolated human LDL is challenged by MPO, there is an oxidation of apoB100 followed by lipoperoxidation.…”

Section: Myeloperoxidasementioning

confidence: 99%

“…In a recent study, no alteration in lycopene concentration, but oxidation of apoB100 and the formation of 7-ketocholesterol were observed. This would indicate that the surface of the LDL particle is more prone to modification following MPO activity and that lycopene has only a very minor if any role as an antioxidant (Chew et al, 2012). 12 mechanisms including the action of NADPH oxidase (NOX).…”

Section: Myeloperoxidasementioning

confidence: 99%

Lycopene and Its Antioxidant Role in the Prevention of Cardiovascular Diseases—A Critical Review

Müller

¹

,

Caris-Veyrat

²

,

Lowe

³

et al. 2015

Critical Reviews in Food Science and Nutrition

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The present review is based mainly on papers published between 2000 and 2011 and gives information about the properties of the carotenoid lycopene in chemical and biological systems and its possible role in preventing cardiovascular diseases (CVD). The main aim of this report is to highlight its role as an antioxidant, also reported are bioactive properties that may influence the development of foam cells and protection against endothelial cell damage. The paper will also examine recent observations that lycopene may improve blood flow and reduce inflammatory responses. Lycopene possesses antioxidant properties in vitro, and some epidemiological studies have reported protective effects against the progression of CVD. The oxidation of human low density lipoproteins (LDL) is a fundamental mechanism in the initiation of atherosclerosis. A beneficial role of lycopene as antioxidant in the prevention of CVD is suggested but the data are still controversial. Lycopene is believed to be the most potent carotenoid antioxidant in vitro. Tissue culture experiments and animal studies support potential cardioprotective effects for lycopene and other carotenoids in the blood. Most studies showed beneficial effects of lycopene to individuals who are antioxidant-deficient like elderly patients, or humans exposed to higher levels of oxidative stress like smokers, diabetics, hemodialysis patients and acute myocardial infarction patients. By defining the right population and combining antioxidant potentials of lycopene with vitamins and other bioactive plant compounds, the beneficial role of lycopene in CVD can be clarified in future studies.

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“…The oxygen-dependent pathway is reliant upon both the activation of NADPH oxidase, an enzyme complex present on the plasma membrane that converts oxygen to superoxide, and also the release of myeloperoxidase from granules of the neutrophils or monocytes [1][2][3][4]. Myeloperoxidase is responsible for the conversion of hydrogen peroxide to hypochlorous acid, a very potent oxidant [5]. The oxygen independent pathways are dependent upon phagocytosis, and the generation of a low pH within the phagolysosome [6].…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with green tea extract promotes enhanced human leukocyte activity

Lowe

¹

,

Gana

²

,

Rahman

³

2015

Journal of Complementary and Integrative Medicine

Self Cite

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Leukocytes play a vital role in the host defence and inflammatory systems, the latter being responsible for the pathogenesis of a wide spectrum of acute and chronic diseases. Green tea is a popular beverage, which is consumed worldwide and its active ingredients are epicatechin derivatives, which possess distinct anti-inflammatory properties. The purpose of this study was to investigate if a green tea extract could enhance leukocyte function in humans.: Volunteers were asked to take 300 mg of the green tea extract daily for 14 days and the capacity of circulating leukocytes to release both myeloperoxidase and lactoferrin was assessed. Whole blood from volunteers was stimulated with the bacterial peptide Formyl-Methionine-Leucine-Phenylalanine (fMet-Leu-Phe). Myeloperoxidase an enzyme that converts hydrogen peroxide to hypochlorous acid and is stored and secreted from the granules of neutrophils and monocytes and was measured as well as lactoferrin which is an iron-binding protein stored and secreted from the neutrophils. In conjunction the antioxidant capacity of the blood of the volunteers was also determined using a chemiluminescence method that measures the capacity of plasma to scavenge superoxide.: After 14 days of treatment there was a significant increase in the release of myeloperoxidase and lactoferrin when whole blood was stimulated with fMet-Leu-Phe (p<0.05), which activates a number of leukocytes including mature neutrophils and monocytes. This was mirrored by a significant increase in the total antioxidant status after 14 days of green tea ingestion (p0.05). After the “wash-out” period of 4 weeks, all parameters were consistent with those observed at the start of the trial (day 0). Treatment with the green tea extract also caused a slight but non-significant decrease in the number of circulating leukocytes, but the counts remained within published “normal” ranges for healthy human adults.: This study indicates that a green tea extract when taken as a dietary supplement for 14 days can increase the leukocyte activity and the total plasma antioxidant status and may have role to play in the prevention of inflammatory disease.

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Does lycopene offer human LDL any protection against myeloperoxidase activity?

Cited by 8 publications

References 24 publications

A Review on Potential Properties and Therapeutic Applications of Lycopene

A Review on Potential Properties and Therapeutic Applications of Lycopene

Lycopene and Its Antioxidant Role in the Prevention of Cardiovascular Diseases—A Critical Review

Dietary supplementation with green tea extract promotes enhanced human leukocyte activity

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