Does malignant hibernoma exist?

Enterline, Horatio T.; Lowry, Louis D.; Richman, Alan V.

doi:10.1097/00000478-197906000-00009

Cited by 43 publications

(20 citation statements)

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“…The malignant potential of this tumor has not been well defined. Enterline et al 24 described the case of an enlarging retropharyngeal mass in a 57-year-old man that was excised because of progressive dyspnea and dysphagia. Histologically, the tumor contained various areas closely resembling a hibernoma and pleomorphic areas reminiscent of a well-differentiated liposarcoma.…”

Section: Discussionmentioning

confidence: 99%

Hibernomas of the head and neck

et al. 1987

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Hibernomas are rare tumors derived from brown adipose tissue, a specialized form of fat tissue found in hibernating and nonhibernating animals. Only a minority of reported hibernomas have occurred in the head and neck region. This report describes two cases of cervical hibernomas, one of which was preoperatively diagnosed by the use of fine-needle aspiration biopsy. The clinical and pathologic characteristics of this neoplasm are reviewed. In general, hibernomas are slow-growing tumors with inconclusive evidence for the existence of a malignant variant. A review of the literature supports the conclusion that excision, sparing vital structures, appears to be curative.

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Section: Discussionmentioning

confidence: 99%

Hibernomas of the head and neck

et al. 1987

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“…Hibernoma is a benign tumour; however, there has been a reported case of hibernoma with an infiltrative pattern and cellular atypia,15 areas of hibernoma and areas consistent with a well-differentiated liposarcoma. Work up in a patient with a suspected fat-containing lesion includes complete history and examination with imaging; fine-needle aspiration cytology is non-diagnostic and core biopsy is discouraged due to the potential of haemorrhage owing to its internal vascularity,8 as also reported in one case leading to excessive bleeding 16…”

Section: Discussionmentioning

confidence: 99%

Hibernoma larynx with large multinodular goitre: unusual airway challenge

Iftikhar

Siddiqui

2015

BMJ Case Reports

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SUMMARYA 56-year-old man presented with a 6-month history of progressively increasing neck swelling, dysphagia and hoarseness of voice. CT scan revealed multi-nodular goitre and also showed a lesion in the supraglottis. It also showed another lesion in the supraglottis. Fine-needle aspiration cytology of thyroid revealed follicular cells. Routine flexible laryngoscopy was performed to evaluate vocal cord function; however, we found a smooth well-defined lesion just above the glottis, obstructing the direct view of the vocal cords, and an endangered airway. A provisional diagnosis of a laryngeal cyst was made. With all necessary precautions intubation was performed with a bougie and a reinforced endotracheal tube was inserted. Total thyroidectomy was performed first. With direct suspension laryngoscopy an attempt was made to deliver the laryngeal lesion, however, the lesion could not be removed. A suprahyoid lateral pharyngotomy was performed to deliver the lesion. Histopathology of the lesion revealed hibernoma. BACKGROUND

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“…The malignant potential of hibernomas has been debated, however, most agree this tumor is completely benign. Enterline et al reported a case of retropharyngeal hibernoma with cellular atypia and an infiltrative pattern; however, metastasis has never been reported. Complicating the matter, hibernomas often closely resemble well‐differentiated and myxoid liposarcomas, which behave much differently.…”

Section: Discussionmentioning

confidence: 99%