Laryngeal hibernoma: Case series of a rare tumor

Cain, Rachel B.; Zarka, Matthew A.; Hinni, Michael L.

doi:10.1002/hed.23460

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Their incidence in the reported literature is very low, with very few cases described in the head and neck region 2. To the best of our knowledge, only four previous cases of hibernoma in the larynx have been described in the literature 2…”

Section: Discussionmentioning

confidence: 91%

“…MRI is the imaging modality of choice; it shows a heterogeneous enhancing mass with focal areas of hypointensity and internal septations. CT scan reveals them as contrast-enhancing lesions that are well circumscribed 2. They are distinguished from lipoma by the presence of internal vessels and fibrous bands 8.…”

Section: Discussionmentioning

confidence: 99%

“…There are two theories linked to the origin of hibernomas, the first suggests remnants of brown fat dispersed in the body from where they grow, the other suggests a transformation of white fat into brown fat and its neoplastic growth 4. There are marked differences between the two types of fat, the white fat stores energy whereas brown fat regulates non-shivering thermogenesis 2. Brown fat is highly vascular, which is similar to appearances of a hibernoma.…”

Section: Discussionmentioning

confidence: 99%

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Hibernoma larynx with large multinodular goitre: unusual airway challenge

Iftikhar

Siddiqui

2015

BMJ Case Reports

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SUMMARYA 56-year-old man presented with a 6-month history of progressively increasing neck swelling, dysphagia and hoarseness of voice. CT scan revealed multi-nodular goitre and also showed a lesion in the supraglottis. It also showed another lesion in the supraglottis. Fine-needle aspiration cytology of thyroid revealed follicular cells. Routine flexible laryngoscopy was performed to evaluate vocal cord function; however, we found a smooth well-defined lesion just above the glottis, obstructing the direct view of the vocal cords, and an endangered airway. A provisional diagnosis of a laryngeal cyst was made. With all necessary precautions intubation was performed with a bougie and a reinforced endotracheal tube was inserted. Total thyroidectomy was performed first. With direct suspension laryngoscopy an attempt was made to deliver the laryngeal lesion, however, the lesion could not be removed. A suprahyoid lateral pharyngotomy was performed to deliver the lesion. Histopathology of the lesion revealed hibernoma. BACKGROUND

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hibernoma larynx with large multinodular goitre: unusual airway challenge

Iftikhar

Siddiqui

2015

BMJ Case Reports

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Lipomatous tumours of the head and neck: a spectrum of biological behaviour

Bree

Karatzanis

Hunt

et al. 2014

Eur Arch Otorhinolaryngol

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Lipomatous tumours are rare in the head and neck region. Their biological behaviour varies greatly, from absolutely benign to histologically benign but locally infiltrative and, finally, invasive with metastatic potential. Each lipomatous tumour has to be treated accordingly. It is of paramount importance before eventual surgery is planned to perform adequate imaging, diagnostic biopsy and careful assessment. Only in small (<5 cm), superficial soft tissue tumours or when magnetic resonance imaging has demonstrated specific features of lipoma, may diagnostic biopsy be omitted. In these cases, expectant management or simple excision is appropriate. Adequate preoperative diagnosis is important to assure adequate tumour control as well as optimal functional and cosmetic outcome. The major problem in the treatment of lipomatous tumours of the head and neck region is the presence of nearby delicate structures. Especially, wide surgical excision of liposarcomas may be hindered by anatomic constraints and may result in impaired functional and cosmetic outcome. Neoadjuvant radiotherapy and specific systemic chemotherapy may be helpful in the treatment of liposarcoma, especially when unresectable or when primary surgery is expected to result in poor oncological, functional or cosmetic outcome. Greater emphasis placed on the underlying biology of individual sarcoma subtypes, development and evaluation of novel therapies and greater specificity in the selection of chemotherapy agents based on activity in individual histological subtypes are expected to lead to improved efficacy of systemic treatment.

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