Does Myopia Affect Angle Closure Prevalence

Jin, Guangming; Ding, Xiaohu; Guo, Xinxing; Chang, Billy; Odouard, Capucine; He, Mingguang

doi:10.1167/iovs.15-16914

Cited by 13 publications

(22 citation statements)

References 33 publications

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“…For example, shallow ACD is the most important risk factor for occludable angle, and the ACD in He Ming Guang’s study was shallower than that in our study. The mean ACD in He Ming Guang’s study increased from 2.68 mm to 2.74 mm when the prevalence of myopia increased from 10% to 60% [ 11 ], whereas in our study, the mean ACD increased from 2.83 (hyperopia group) to 3.08 (myopia group). This shows that the upper limit of the mean ACD in their study (2.74 mm, 60%myopia) was still shallower than the lower limit of the mean ACD (2.83 mm, 100% hyperopia) in our study.…”

Section: Discussioncontrasting

confidence: 77%

“…However, Kai-lin Yong reported that almost one quarter of angle-closure patients were myopic [ 7 ]. He Ming Guang reported that the increasing prevalence of myopia has minimal impact on the prevalence of occludable angles, with myopia increasing from 10% to 60% and narrow angle prevalence decreasing from 11.1% to 9.6% [ 11 ]. The difference between our study and Kai-lin Yong’s study may associate with subject selection bias.…”

Section: Discussionmentioning

confidence: 99%

“…If it is true that subjects with myopia have a low chance of developing angle closure, the prevalence of occludable angles in Chinese people may decrease with increasing myopia prevalence. However, He Ming Guang reported that the increasing prevalence of myopia has a minimal impact on the prevalence of occludable angles [ 11 ]. However, the aforementioned study was not a randomized study, and the prevalence of myopia was altered by the selection of a certain proportion of myopia subjects, which inevitably results in selection bias.…”

Section: Introductionmentioning

confidence: 99%

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Association between Myopia, Biometry and Occludable Angle: The Jiangning Eye Study

Liu

Zhang

et al. 2016

PLoS ONE

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BackgroundMyopia subjects usually have long axial lengths and are predisposed to deep anterior chamber depths and open angles. Jiangning eye study is a randomized, population based study in Shanghai to determine whether myopia has an effect on the prevalence of occludable angles.MethodsA total of 2478 residents aged 50 years and over were randomly selected, and 2044 (82.5%) individuals of them participated in ophthalmic examinations between November 2012 and February 2013. Eye examinations included autorefraction, noncontact tonometry, measurement of axial length, anterior chamber depth, lens thickness and spectral domain optical coherence tomography.ResultsThe crude prevalences of iris trabecular meshwork contact in Jiangning Chinese individuals with myopia, emmetropia, and hyperopia are 1.25%, 6.44%, and 7.43%, respectively. There is also iris trabecular meshwork contact and shallow anterior chamber depth in myopia subjects even with long axial lengths.ConclusionsThe prevalence of iris trabecular meshwork contact in myopia subjects is lower than their emmetropia or hyperopia counterparts. Axial length is an important factor associate with occludable angle.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Myopia, Biometry and Occludable Angle: The Jiangning Eye Study

Liu

Zhang

et al. 2016

PLoS ONE

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“…A Singaporean study showed that almost one-quarter of PAC was myopic, 5 whereas a Malaysian investigation found that the distribution of myopia was approximately 37% in PAC patients. 6 Jin et al 7 concluded that the increasing prevalence of myopia has minimal influence on the angle-closure prevalence. It seems that we are going to have more myopic PAC with the rise of myopia in the world, especially in East Asia.…”

mentioning

confidence: 99%

What Are the Characteristics of Primary Angle Closure With Longer Axial Length?

Chen

Jiang

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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What are the characteristics of primary angle closure with longer axial length? Invest Ophthalmol Vis Sci. 2018;59:1354-1359. https://doi.org/10.1167 PURPOSE. To compare biometric parameters between primary angle closure with longer axial length (AL) and those with medium or shorter AL. METHODS.We prospectively recruited 138 primary angle-closure patients. Low-coherence interferometry and ultrasound biomicroscopy examinations were performed before laser peripheral iridotomy and pilocarpine treatment. AL was categorized as shorter (<22.5 mm), medium ( ‡22.5 to <23.5 mm), or longer ( ‡23.5 mm). Anterior chamber depth and width (ACD and ACW), lens vault (LV), anterior vault (AV), relative AV (AV/AL), relative lens position (RLP, [ACD þ 1/2 lens thickness]/AL), trabecular-ciliary angle (TCA), keratometry, and other biometric parameters were compared among different AL groups.RESULTS. Among 138 angle-closure patients, 15 (10.9%) patients had longer ALs, of which 11 (73.3%) were male. These angle-closure eyes with longer AL had flatter cornea (P ¼ 0.006 and 0.022 for flat and steep keratometry) and larger ACW (P ¼ 0.006), but smaller RLP (P ¼ 0.019) than those with medium AL; similarly, they had flatter cornea (P < 0.001 for both flat and steep keratometry), and larger ACW (P < 0.001), AV (P ¼ 0.004), and TCA (P ¼ 0.024), but smaller relative AV (P ¼ 0.040) and RLP (P ¼ 0.005) than those with shorter AL. No significant differences were found in the other parameters.CONCLUSIONS. Primary angle closure with longer AL was uncommon. Causes of angle closure in these atypical patients were manifold. These patients were predominantly male; they had smaller relative dimension of the anterior segment, flatter cornea, and more anterior RLP and less anteriorly rotated ciliary body compared with those angle-closure patients with relatively shorter AL.Keywords: myopia, primary angle closure, axial length, biometric parameters P rimary angle closure (PAC) with myopia has received increasing attention in recent years. This is not only because myopia, usually regarded as a protective effect against PAC, can still be observed in some angle-closure patients, 1-4 but also because this kind of PAC may significantly rise with the incremental rate of myopia in East Asia in the future.5 Recent researchers have highlighted that there is a considerable proportion of myopia in the PAC population. A Singaporean study showed that almost one-quarter of PAC was myopic, 5 whereas a Malaysian investigation found that the distribution of myopia was approximately 37% in PAC patients.6 Jin et al. 7 concluded that the increasing prevalence of myopia has minimal influence on the angle-closure prevalence. It seems that we are going to have more myopic PAC with the rise of myopia in the world, especially in East Asia. However, myopia by the definition of the refractive status in angle-closure patients is often misleading. It is well known that PAC usually occurs in the population older than 40 years, 8 so the myopia formation in these patients might be...

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“… 3 , 4 However, simulation analysis of the Liwan Eye Study reported that the myopia had minimal effect on PACG prevalence. 5 Recent studies, on the other hand, have highlighted that a significant proportion of patients with PACG have myopia, with approximately one-third of rural patients with PACG in rural China having myopia, and nearly 37% of patients with PACG in Malaysia having myopia. 6 , 7 PACG can also occur in high myopic eyes, with 1.9% to 2.6% of patients with PACG are highly myopic.…”

Section: Introductionmentioning

confidence: 99%

Effect of High Myopia on Dynamic Changes of Anterior Angle After Pharmacologic Mydriasis in Cataract Patients: A SS-ASOCT Study

Wang

Zhang

et al. 2021

Trans. Vis. Sci. Tech.

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Purpose The purpose of this study was to evaluate the effect of high myopia on anterior angle change after pharmacologic mydriasis in patients with cataract using swept-source anterior segment optical coherence tomography (SS-ASOCT). Methods This prospective cross-sectional study continuously recruited patients with cataract aged 40 years and older during the period August 2019 to August 2020. The anterior segment parameters, including central corneal thickness (CCT), anterior chamber depth (ACD), angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), trabecular-iris angle (TIA), angle to angle width (ATA), and anterior chamber volume (ACV), were obtained using SS-ASOCT at baseline and 30 minutes after mydriasis. Regression analyses were performed to identify the factors related to the relative change of AOD500 (ΔAOD500). Results A total of 938 patients (938 eyes) were included. The AOD500 decreased from 0.46 ± 0.22 mm to 0.40 ± 0.19 mm, with percent ΔAOD500 of −13.59% ± 37.73% ( P = 0.005). The patients with high myopia had a smaller reduction of anterior angle parameters, with a percent ΔAOD500 of −22.74% ± 58.09%% in non-high myopic eyes and −0.84% ± 45.47% in high myopic eyes ( P < 0.001). The stepwise multivariate regression demonstrated that the smaller reduction of AOD500 were independently associated with younger age (coefficient = −2.11, 95% confidence interval [CI] = −2.59 to −1.64, P < 0.001), presence of high myopia (coefficient = 15.35, 95% CI = 3.63 to 27.07, P = 0.010), greater baseline TISA500 (coefficient = 60.78, 95% CI = 8.75 to 112.82, P = 0.022), and ATA (coefficient = 11.21, 95% CI = 4.53 to 17.89, P = 0.001). Conclusions The anterior chamber angle decreased after pharmacologic mydriasis in these patients with cataract. Angle shallowing after pharmacologic mydriasis was significantly less pronounced in high myopic eyes than in non-high myopic eyes. Translational Relevance These findings are informative for the relative less risk of angle-closure glaucoma in highly myopic eyes.

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Does Myopia Affect Angle Closure Prevalence

Cited by 13 publications

References 33 publications

Association between Myopia, Biometry and Occludable Angle: The Jiangning Eye Study

Association between Myopia, Biometry and Occludable Angle: The Jiangning Eye Study

What Are the Characteristics of Primary Angle Closure With Longer Axial Length?

Effect of High Myopia on Dynamic Changes of Anterior Angle After Pharmacologic Mydriasis in Cataract Patients: A SS-ASOCT Study

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