Does Nanosilver Have a Pronounced Toxic Effect on Humans?

Ivlieva, A. L.; Petritskaya, E. N.; Рогаткин, Д. А.; Yushin, Nikita; Grozdov, Dmitrii; Vergel, Konstantin; Zinicovscaia, Inga

doi:10.3390/app12073476

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…Nevertheless, in a recent review, Ivlieva and collaborators concluded that the toxicity is mostly due to the liberation of Ag + and not from the nanoparticle itself, showing the importance of a good stability of the AgNPs for its safety. 27 Additionally, Maziero and her team have shown that AgNPs stabilized with Gum Arabic Protein revealed adverse effects in zebrafish species but not in Sprague Dawley rats for 28 days in doses up to 10.0 mg/kg which shows the potential of their usage and the importance of their study. 28 Thus, the purpose of this study was to synthesize and characterize AgNPs functionalized with glucose (G-AgNPs) and further study their cytotoxic and cellular effect in PCa cells resistant to ADT.…”

Section: Introductionmentioning

confidence: 99%

Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells

Morais¹,

Machado²,

Dias³

et al. 2022

IJN

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Purpose Silver nanoparticles (AgNPs) have shown great potential as anticancer agents, namely in therapies’ resistant forms of cancer. The progression of prostate cancer (PCa) to resistant forms of the disease (castration-resistant PCa, CRPC) is associated with poor prognosis and life quality, with current limited therapeutic options. CRPC is characterized by a high glucose consumption, which poses as an opportunity to direct AgNPs to these cancer cells. Thus, this study explores the effect of glucose functionalization of AgNPs in PCa and CRPC cell lines (LNCaP, Du-145 and PC-3). Methods AgNPs were synthesized, further functionalized, and their physical and chemical composition was characterized both in water and in culture medium, through UV-visible spectrum, dynamic light scattering (DLS), transmission electron microscopy (TEM) and Fourier-transform infrared spectroscopy (FTIR). Their effect was assessed in the cell lines regarding AgNPs’ entering pathway, cellular proliferation capacity, ROS production, mitochondrial membrane depolarization, cell cycle analysis and apoptosis evaluation. Results AgNPs displayed an average size of 61nm and moderate monodispersity with a slight increase after functionalization, and a round shape. These characteristics remained stable when redispersed in culture medium. Both AgNPs and G-AgNPs were cytotoxic only to CRPC cells and not to hormone-sensitive ones and their effect was higher after functionalization showing the potential of glucose to favor AgNPs’ uptake by cancer cells. Entering through endocytosis and being encapsulated in lysosomes, the NPs increased the ROS, inducing mitochondrial damage, and arresting cell cycle in S Phase, therefore blocking proliferation, and inducing apoptosis. Conclusion The nanoparticles synthesized in the present study revealed good characteristics and stability for administration to cancer cells. Their uptake through endocytosis leads to promising cytotoxic effects towards CRPC cells, revealing the potential of G-AgNPs as a future therapeutic approach to improve the management of patients with PCa resistant to hormone therapy or metastatic disease.

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Section: Introductionmentioning

confidence: 99%

Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells

Morais¹,

Machado²,

Dias³

et al. 2022

IJN

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A Novel Approach to Produce Metal–Metal Composites by Leveraging Immiscibility: Laser Powder Bed Fusion of Nanosilver‐Dispersed Titanium

Shokri,

Rittinghaus,

Schmelzer

et al. 2024

Adv Eng Mater

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The antimicrobial properties of silver ions are well known and effectively utilized in various biomedical applications. The efficacy of silver‐containing materials, particularly in terms of antimicrobial activity, heavily relies on the oxidizing surface, favoring nanosized silver features. However, producing such structures is challenging due to the high probability of miscibility in the liquid phase. Developing Ti–Ag composite alloys using the laser powder bed fusion technique with supported titanium powders and silver nanoparticles (AgNPs) represents a novel research pursuit, with no prior investigations reported. Incorporating AgNPs into titanium forms nanoislands, directly enhancing the antimicrobial efficacy of biomedical components. In this study, it is aimed to explore the solubility limit of silver in titanium and the feasibility of achieving finely dispersed silver islands. Experimental findings reveal that incorporating AgNPs into Ti‐based alloys results in discrete silver islands (0.01–0.02 μm2) within the microstructure, governed by the solubility limit of silver in titanium. In this study, valuable insights into producing components with augmented biocompatibility and proven antibacterial properties against Staphylococci infections are offered. The successful development of Ti–Ag composite alloys, featuring finely dispersed silver islands, opens promising avenues for biomedical applications, enhancing their antibacterial characteristics and improving patient outcomes.

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