Does neutrophyl to lymphocyte ratio really predict chronic kidney disease progression?

Altunören, Orçun; Akkus, Gulsum; Sezal, Didem Tutuncu; Çiftçioğlu, Muhammed; Güzel, Fatma Betül; Işiktaş, Songül; Törün, Gül İnci; Uyan, Merve; Sökmen, Murat Fatih; Sevim, Hatıce Ayyildiz; Sarisik, Feyza Nur; Şenel, Mahmut Egemen; Erken, Ertuğrul; Güngör, Özkan

doi:10.1007/s11255-018-1994-7

Cited by 29 publications

(22 citation statements)

References 25 publications

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“…In another study with 740 patients and 5 years follow up period showed that DM, young age and initial eGFR were independent factors in progression to ESRD in Coxregression analysis. [24] In our study, we found that DM and baseline eGFR are independent predictors of ESRD and renal poor outcome (ESRD+mortality) in Cox-Regression analysis.…”

Section: Discussionsupporting

confidence: 49%

Evaluation of the Relationship Between Neutrophil to Lymphocyte Ratio and Renal Outcomes Patients With Chronic Renal Disease

Erkuş

Karakose

Ergul

et al. 2020

Journal of Contemporary Medicine

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Böbrek hastalığının nedenine bakılmaksızın, kronik böbrek hastalığı (KBH) ve Son Evre Böbrek Hastalığı (SDBY) olan yetişkinlerde akut ve kronik proinflamatuar bir durumun var olduğuna ve inflamasyonun morbidite ve mortaliteye katkıda bulunduğuna dair güçlü kanıtlar vardır. Bu çalışmada, CRD hastalarında nötrofil / lenfosit oranının (NLR) ve trombosit/lenfosit oranının (PLR) kötü böbrek sonucu (ESRD + Ölüm) ile ilişkili olup olmadığını araştırmayı amaçladık. Gereç ve Yöntem: Nefroloji polikliniğine düzenli olarak başvuran 194 Türk CRD (evre 3-5) çalışmaya alındı. Dört yıllık izlem süresi sonunda hasta kayıtları böbrek durumuna ve mortaliteye göre değerlendirildi. Bulgular: Takip süresi boyunca 194 hastadan 15'i öldü, 89 hastaya renal replasman tedavisi başlandı ve 90 hasta halen ESRD olmayan hastalar olarak takip edilmektedir. ESRD olan hastalar ESRD olmayan hastalar ile karşılaştırıldığında erkek cinsiyet, takip süresi, Vücut kitle indeksi, Sistolik kan basıncı, Diastolik kan basıncı, başlangıç eGFR, albümin, Hemoglobin, kalsiyum, fosfor, NLR, PLR ve spot idrar kreatin oranı arasında istatistiksel olarak anlamlı bir fark vardı. NLR, CRD hastalarında hastalığın ilerlemesi ve kötü böbrek sonucu için bağımsız bir risk faktörü olarak bulundu. Sonuç: Sonuç olarak, NLR'nin CRD hastalarında bağımsız bir ESRD ve kötü böbrek sonucu öngörücüsü olduğunu gösterdik. Bu nedenle NLR ölçümü, CRD hastalarında böbrek hastalığının ilerlemesini tahmin etmede yararlı olabilir.

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Section: Discussionsupporting

confidence: 49%

Evaluation of the Relationship Between Neutrophil to Lymphocyte Ratio and Renal Outcomes Patients With Chronic Renal Disease

Erkuş

Karakose

Ergul

et al. 2020

Journal of Contemporary Medicine

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“…NLR displays a prognostic value for proteinuria [32, 33], mortality and RRT [34]. Nevertheless, recent evidence indicates NLR was not an independent predictor of CKD progression in CKD stage 2–4 patients [35]. In our study of a large chinese CKD population for relationship between NLR, ESRD, CVD, or all-cause mortality, our longitudinal study revealed NLR as an independent risk factor of ESRD only in patients with stage 4 CKD after adjusting for classic risk factors of CKD including ACR and eGFR.…”

Section: Discussionmentioning

confidence: 99%

“…These patients have severely damaged renal function prior to dialysis [36]; chronic low-grade inflammation will likely promote disease progression towards ESRD in stage 4 CKD patients. In this regard, NLR may not be an independent predictor of CKD progression in patients with CKD at early stages [35]. In renal replacement patients, including hemodialysis and peritoneal dialysis, evidence suggests that NLR predicts CVD and all-cause mortality [7].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Yuan

Wang²,

Peng

et al. 2019

J Transl Med

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BackgroundChronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute to these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymphocyte ratio (NLR). We aimed to investigate the association of NLR with the progression of end stage of renal disease (ESRD), cardiovascular disease (CVD) and all-cause mortality in Chinese patients with stages 1–4 CKD.MethodsPatients with stages 1–4 CKD (18–74 years of age) were recruited at 39 centers in 28 cities across 22 provinces in China since 2011. A total of 938 patients with complete NLR and other relevant clinical variables were included in the current analysis. Cox regression analysis was used to estimate the association between NLR and the outcomes including ESRD, CVD events or all-cause mortality.ResultsBaseline NLR was related to age, hypertension, serum triglycerides, total serum cholesterol, CVD history, urine albumin to creatinine ratio (ACR), chronic kidney disease-mineral and bone disorder (CKD-MBD), hyperlipidemia rate, diabetes, and estimated glomerular filtration rate (eGFR). The study duration was 4.55 years (IQR 3.52–5.28). Cox regression analysis revealed an association of NLR and the risk of ESRD only in patients with stage 4 CKD. We did not observe any significant associations between abnormal NLR and the risk of either CVD or all-cause mortality in CKD patients in general and CKD patients grouped according to the disease stages in particular.ConclusionOur results suggest that NLR is associated with the risk of ESRD in Chinese patients with stage 4 CKD. NLR can be used in risk assessment for ESRD among patients with advanced CKD; this application is appealing considering NLR being a routine test.Trial registration ClinicalTrials.gov Identifier NCT03041987. Registered January 1, 2012. (retrospectively registered) (https://www.clinicaltrials.gov/ct2/show/NCT03041987?term=Chinese+Cohort+Study+of+Chronic+Kidney+Disease+%28C-STRIDE%29&rank=1)Electronic supplementary materialThe online version of this article (10.1186/s12967-019-1808-4) contains supplementary material, which is available to authorized users.

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“…Chronic kidney disease (CKD) is a worldwide public health problem because of long life expectancy, increased frequency of diabetes and hypertension (1). Regardless of etiology, it is a progressive disease and the rate of progression is unpredictable (1). CKD is characterized by an increase in cardiovascular mortality as compared to general population.…”

Section: Introductionmentioning

confidence: 99%

Red blood cell distribution width is a predictor of chronic kidney disease progression and all-cause mortality

Yılmaz¹,

Sözel²

2021

BLL

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Does neutrophyl to lymphocyte ratio really predict chronic kidney disease progression?

Cited by 29 publications

References 25 publications

Evaluation of the Relationship Between Neutrophil to Lymphocyte Ratio and Renal Outcomes Patients With Chronic Renal Disease

Evaluation of the Relationship Between Neutrophil to Lymphocyte Ratio and Renal Outcomes Patients With Chronic Renal Disease

Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Red blood cell distribution width is a predictor of chronic kidney disease progression and all-cause mortality

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