Does oval oocyte have an impact on embryo development in in vitro fertilization?

Abstract

ObjectiveTo compare the outcomes of embryo development between oval-shaped oocyte as an abnormal morphology oocyte and a normal morphology oocyte in In Vitro Fertilization (IVF).MethodsThis study was a comparative analytical study with retrospective approach which lasted from September 2014 until November 2015. For this study, we used secondary data (medical records) from 24 patients submitted to IVF at the Halim Fertility Center. The oocyte morphology was divided into two groups: normal-shaped oocyte and oval-shaped oocyte.ResultsOur study included 120 oocytes with 60 oval-shaped oocytes and 60 normal oocytes. We found fertilization rates of 68.3% in the normal oocyte group and 61.7% in the oval-shaped oocyte group; and there was no significant difference between the normal oocyte group and the oval-shaped oocyte group (p > 0.05). In the normal oocyte group, 65% had reached day 3 embryos, and in the oval-shaped oocyte group it was 50%, with no significant difference between the groups (p > 0.05). We also found 46.7% transferrable embryos in the oval oocytes group compared to 63.3% in the normal oocytes group, with no significant difference between the groups (p > 0.05).ConclusionThere was no significant difference in fertilization rates and embryo quality between normal morphology oocytes and oval-shaped oocytes.

Impact of Oocyte Morphology on Fertilization, Embryo Quality and Pregnancy after ICSI: Evaluation with Diabetes and PCOS

“…Halim et al in their research compared normal and oval shaped oocytes in ICSI and found 46.7% transferrable embryos in the oval oocytes group compared to 63.3% in the normal oocytes group. However, there was no significant difference in fertilization rates and embryo quality between normal morphology oocytes and oval-shaped oocytes, but with a higher percentage towards the normal shaped oocytes [27].…”

Vitrifying multiple embryos in different arrangements does not alter the cooling rate

“…Cumulus cells are not included, as these are removed according to the Open Cryotop ® user manual [20]. Only uniform samples are considered, as deviation from a spherical shape is considered a form of dysmorphia [14]. The choice of 0.1mm is a conservative size estimate, and accounts for loss of water volume and artificial collapse during the vitrification process.…”

Vitrifying multiple embryos in different arrangements does not alter the cooling rate⋆

“…Cumulus cells are not included, as these are required to be removed according to the Open Cryotop ® user manual [17]. Uniform embryos are considered, as deviation from a spherical shape is considered a form of dysmorphia [24]. The choice of 0.1mm is a conservative size estimate, and accounts for loss of water volume and artificial collapse during the vitrification process.…”