Does platelet-rich plasma enhance healing in the idiopathic bone cavity? A single-blind randomized clinical trial

Karagah, Tuba; Shahidi, Shoaleh; Zare, N

doi:10.1016/j.ijom.2015.05.011

Cited by 16 publications

(8 citation statements)

References 21 publications

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“…Because of limitations in access as well as problems at the donor site (such as chronic pain and infection), tissue engineering using cell therapy (mesenchymal stem cells) [ 31 ], growth factors (PRP, PRGF) [ 86–88 ] and a combination of the both [ 89–92 ] has been suggested as bone graft alternatives in recent decades [ 26 , 93 ]. Iranian researchers have conducted human [ 94 ] and animal studies using different platelet products as well as their combination with various substances such as human amniotic fluid [ 95 ], hydroxyapatite [ 96 , 97 ], Persian Gulf coral [ 98 ] and deproteinized bovine bone mineral [ 99 ] for bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

An Overview of Platelet Products (PRP, PRGF, PRF, etc.) in the Iranian Studies

et al. 2017

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Aim:The aim of the study was to carry out a review of published studies on various platelet products in Iranian studies.Materials & methods:Electronic databases were searched for relevant articles. Two review authors independently extracted data via a tested extraction sheet, and disagreements were resolved by a meeting with a third review author.Results:Bone disorders (25%), wound and fistula (16%), dental and gingival disorders (14%) and osteoarthritis (11%) have more relative frequency based on different fields.Conclusion:The necessity of pursuing standard protocols in the preparation of platelet products, stating the precise content of platelets and growth factors, and long-term follow-up of study subjects were the most important points in Iranian studies.

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Section: Discussionmentioning

confidence: 99%

An Overview of Platelet Products (PRP, PRGF, PRF, etc.) in the Iranian Studies

et al. 2017

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“…To counter this increasing phenomenon, both in human and in veterinary medicine, more and more scientists are looking for molecules that can assist or replace the action of antibiotics. The topical use of non-transfusional hemo-components or autologous platelet concentrates (PCs), including platelet-rich plasma (PRP), platelet gel (PG), platelet lysate (PL), and fibrin glue (FG), has gained great popularity during the past 20 years; thus, they have been used, mainly for their regenerative properties, in a variety of human medical fields such as orthopedics ( 3 – 7 ), wound healing ( 8 – 12 ), ophthalmology ( 13 – 15 ), and dentistry ( 16 – 20 ). Despite a recent growing interest, fewer in vivo and in vitro studies in dogs have been published ( 21 – 26 ).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of Canine Platelet-Rich Plasma and Other Non-Transfusional Hemo-Components: An in vitro Study

et al. 2021

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This in vitro study was carried out to evaluate the potential antibacterial properties of canine non-transfusional hemo-components. Therapeutic formulations commonly used for regenerative medicine purposes (platelet-rich plasma, platelet gel, platelet lysate, fibrin glue), considering both leukocyte-rich and leukocyte-poor formulations, but also platelet-poor plasma and activating substances (thrombin, calcium gluconate), were tested to detect elements with potential antimicrobial properties. The antibacterial effect was tested on different bacterial strains (Staphylococcus aureus subspecies aureus, Staphylococcus cohnii subspecies cohnii, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae subspecies pneumoniae) isolated from canine wounds and classified as susceptible, multidrug-, extensively, and pandrug-resistant bacteria toward a known panel of human and veterinary antibiotics. The evaluation was carried out by agar gel diffusion method (Kirby–Bauer) and micro-inhibition in broth using microplates and spectrophotometer reading. The study findings confirmed the hypothesized antibacterial properties of canine non-transfusional hemo-components. A more effective bacteriostatic effect was found against Gram-negative bacteria, drug-resistant too. The presence of leukocytes or platelets does not appear to be essential for the antibacterial effect. Further studies should be conducted to evaluate the exact mechanism of action of the antimicrobial activity. However, non-transfusional hemo-components could be a useful natural aid in controlling bacterial infections in dogs.

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“…On the other hand, autologous plasma concentrates are a new approach for tissue regeneration in various surgical fields, such as dental and oral surgery. Specifically, they are used in the post-extraction sockets, where they seem to promote healing and soft tissue epithelialization, in procedures relating to the placement of osseointegrated implants, for the treatment of infrabony periodontal defects and periodontal plastic surgery, and, recently, they have been also investigated for bone regeneration [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Platelet aggregates are autologous sources of various growth factors, such as VEGF (vascular endothelial growth factor), PDGF-AB (platelet-derived growth factor AB), and TGFb-1 (transforming growth factor b-1) [ 7 , 9 ], which are also found during natural healing and are able to stimulate cell proliferation, matrix remodelling, and angiogenesis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Multifunctional Bioerodible Nanocomposite Containing Metronidazole and Curcumin to Apply on L-PRF Clot to Promote Tissue Regeneration in Dentistry

et al. 2020

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Teeth extractions are often followed by alveolar bone reabsorption, although an adequate level of bone is required for reliable rehabilitations by dental implants. Leukocyte and platelet-rich fibrin (L-PRF) has been widely applied in regenerative procedures and with antibiotic and antioxidant agents could play an essential role in hard and soft tissue healing. In this work, a nanocomposite (Sponge-C-MTR) consisting of a hyaluronate-based sponge loaded with metronidazole (MTR) and nanostructured lipid carriers containing curcumin (CUR-NLC) was designed to be wrapped in the L-PRF™ membrane in the post-extraction sockets and characterized. CUR-NLCs, obtained by homogenization followed by high-frequency sonication of the lipid mixture, showed loading capacity (5% w/w), drug recovery (95% w/w), spherical shape with an average particle size of 112.0 nm, and Zeta potential of −24 mV. Sponge-C-MTR was obtained by entrapping CUR-NLC in a hydrophilic matrix by a freeze-drying process, and physico-chemical and cytocompatibility properties were evaluated. Moreover, the aptitude of CUR and MTR to the penetrate and/or permeate both L-PRF™ and porcine buccal tissue was assessed, highlighting MTR penetration and CUR accumulation promoted by the system. The results positively support the action of nanocomposite in dental tissues regeneration when applied together with the L-PRF™.

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Does platelet-rich plasma enhance healing in the idiopathic bone cavity? A single-blind randomized clinical trial

Cited by 16 publications

References 21 publications

An Overview of Platelet Products (PRP, PRGF, PRF, etc.) in the Iranian Studies

An Overview of Platelet Products (PRP, PRGF, PRF, etc.) in the Iranian Studies

Antibacterial Properties of Canine Platelet-Rich Plasma and Other Non-Transfusional Hemo-Components: An in vitro Study

Development of a Multifunctional Bioerodible Nanocomposite Containing Metronidazole and Curcumin to Apply on L-PRF Clot to Promote Tissue Regeneration in Dentistry

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