Does postcholecystectomy increase the risk of colorectal cancer?

Dong, Zhenyu; Shi, Ruixian; Li, Pengda; Song, Xiaobiao; Fan, Daiming; Zhu, Jie; Wu, Riga; Liu, Zhi; Sun, Jianguo; Wang, Jijun; Yang, Zhigang

doi:10.3389/fmicb.2023.1194419

Cited by 3 publications

(1 citation statement)

References 126 publications

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“… 53 The research suggests that postcholecystectomy changes in bile acid metabolism and disruptions in gut microbiota may be contributing factors to the development of colorectal cancer. 54 Furthermore, results from a study conducted in China suggest that the gut microbiota may play a crucial role in the development of colorectal cancer induced by appendectomy. 55 However, our data did not fully support this conclusion, possibly because some of our positive patients had a history of appendicitis or cholecystitis rather than surgical removal of these organs.…”

Section: Dissusionmentioning

confidence: 99%

Factors influencing advanced colorectal neoplasm anatomic site distribution in China: An epidemiological study based on colorectal cancer screening data

Zhao,

Li,

Zhang

et al. 2023

Cancer Medicine

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ObjectiveExisting studies indicate that advanced colorectal neoplasms exhibit distinct clinical and biological traits based on anatomical sites. However, in China, especially for advanced colorectal neoplasms, there's limited information available on these traits. Our primary objective is to comprehensively study the characteristics of advanced colorectal neoplasm patients in different anatomical sites in China.MethodsWe selected information from the colorectal cancer screening database in Tianjin, China, since 2010 as the study subject. We chose valid information from 3113 patients with comprehensive data and diagnosed advanced colorectal neoplasms (ANs) from a pool of 19,308 individuals to be included in the study. We then conducted further analysis to examine the correlation between these epidemiological data and tumor location.ResultsAmong the 3113 patients, neoplasms in the left side of the colon accounted for the largest proportion, while neoplasms in the right side of the colon had the smallest proportion, followed by rectal neoplasms. The highest proportion of advanced colorectal neoplasms was found among men. In the age group of 39–49 years old, the proportion of left late‐stage advanced colon neoplasms was equal to that of right late‐stage advanced colon neoplasms, while late‐stage advanced rectal neoplasms increased with age. Smoking, drinking, and a history of colon cancer in first‐degree relatives showed statistically significant associations with the location distribution of advanced colorectal neoplasms. A history of appendicitis, appendectomy, cholecystitis, or cholecystectomy did not significantly affect the location distribution of advanced colorectal neoplasms. However, among patients with such histories, there was a statistically significant relationship between advanced colon neoplasms on the right and those on the left and in the rectum. Similar results were observed for BMI.ConclusionOur research findings demonstrate that advanced colorectal neoplasms display unique epidemiological characteristics depending on their anatomical locations, and these distinctions deviate from those observed in Western populations. These insights contribute to a more comprehensive understanding of the topic and offer valuable guidance for future research in China. We advocate for further investigations centered on the anatomical location of colorectal neoplasms to enhance the precision of colorectal cancer (CRC) screening and treatment.

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Section: Dissusionmentioning

confidence: 99%

Factors influencing advanced colorectal neoplasm anatomic site distribution in China: An epidemiological study based on colorectal cancer screening data

Zhao,

Li,

Zhang

et al. 2023

Cancer Medicine

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A review of endoscopic ultrasound-guided gallbladder drainage and gastroenterostomy: assisted approaches and comparison with alternative techniques

Xu,

Zhang,

Guo

et al. 2024

Therap Adv Gastroenterol

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Over the last 40 years, the role of endoscopic ultrasound (EUS) has evolved from being diagnostic to therapeutic. EUS-guided gallbladder drainage (EUS-GBD) and EUS-guided gastroenterostomy (EUS-GE) are emerging techniques in recent years; however, there are limited studies and inconsistent results regarding these techniques. In addition, EUS has become a more common alternative to traditional interventions due to its super minimally invasive nature, but the mobility of both the gallbladder and intestine makes it challenging to introduce stents. An increasing number of researchers are dedicating themselves to solving this problem, leading to the development of various assisted technologies. Consequently, this review focused on the comparison of EUS-GBD and EUS-GE with other alternative approaches and explored the various assisted techniques employed for EUS-GBD and EUS-GE.

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Neither cholelithiasis nor cholecystectomy is causally associated with colorectal cancer: A univariate and multivariate mendelian randomization study

Qin,

Zhou,

Ren

et al. 2024

Preprint

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Background Epidemiological studies reported controversial results regarding the relationship between cholelithiasis, cholecystectomy and colorectal cancer (CRC). In the presence of reverse causality and confounding factors, findings of our previous retrospective study that it was gallbladder disease rather than cholecystectomy that was a risk factor for colorectal cancer was not sufficiently convincing. Therefore, we used Mendelian randomization (MR) to further explore the relationship between cholelithiasis or cholecystectomy and CRC. Methods We performed a univariate MR (UVMR) and multivariate MR (MVMR) analysis of 1,054,773 samples and 37,970,958 SNPs from three European genome-wide association studies (GWAS) to explore the causality of cholelithiasis, cholecystectomy and CRC. The forward analysis, with cholelithiasis or cholecystectomy as exposure and CRC as outcome, included UVMR and MVMR analysis. In UVMR, 21 and 30 independent SNPs strongly (P < 5*10− 8) associated with cholelithiasis on CRC and cholecystectomy on CRC were extracted as valid instrumental variables (IVs); in MVMR, 14 and 26 valid IVs were extracted, respectively. The inverse analysis, with CRC as exposure and cholelithiasis or cholecystectomy as outcome, only included MVMR. 9 and 7 IVs strongly associated with CRC on cholelithiasis and CRC on cholecystectomy were extracted, respectively. MR results were estimated using multiplicative random effects-inverse variance weighted (MRE-IVW), simple mode (SM), weighted median (WME), weighted mode (WMO) and MR-Egger regression methods, respectively. Sensitivity analysis was performed using heterogeneity test, pleiotropy test and leave-one-out test. MR results were presented using scatter plots, forest plots and funnel plots. Results In the forward analysis, neither UVMR nor MVMR analysis estimated by MRE-IVW revealed a causal relationship between cholelithiasis on CRC (OR = 1.0002, 95% CI = 0.999–1.001, P = 0.729 and OR = 1.0003, 95% CI = 0.998–1.003, P = 0.799, respectively) or between cholecystectomy on CRC (OR = 0.9917, 95% CI = 0.963–1.022, P = 0.582 and OR = 0.9897, 95% CI = 0.936–1.046, P = 0.715, respectively). In the inverse analysis, MRE-IVW estimates also revealed little evidence for a causal relationship between CRC on cholelithiasis (OR = 0.0504, 95% CI = 0.001–2.871, P = 0.147) or between CRC on cholecystectomy (OR = 0.9894, 95% CI = 0.792–1.236, P = 0.925). Results from other MR estimation methods were consistent with MRE-IVW. Sensitivity analysis confirmed the stability and reliability of results. Conclusions Our two-sample univariate and multivariate MR analysis revealed neither cholelithiasis nor cholecystectomy was causally associated with colorectal cancer.

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Does postcholecystectomy increase the risk of colorectal cancer?

Cited by 3 publications

References 126 publications

Factors influencing advanced colorectal neoplasm anatomic site distribution in China: An epidemiological study based on colorectal cancer screening data

Factors influencing advanced colorectal neoplasm anatomic site distribution in China: An epidemiological study based on colorectal cancer screening data

A review of endoscopic ultrasound-guided gallbladder drainage and gastroenterostomy: assisted approaches and comparison with alternative techniques

Neither cholelithiasis nor cholecystectomy is causally associated with colorectal cancer: A univariate and multivariate mendelian randomization study

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