Reviewing national literature on homicides in Brazil, this article explores questions that relate to the nature, trends, determinants, and impact of these crimes on society, as well as interventions to combat this type of violence. The article contributes to the international literature by reviewing and critically discussing a sample of 112 theses on homicides from the Portuguese-language literature using the Brazilian Digital Library of Theses and Dissertations from 2000 to 2020. Highlighting an issue that primarily affects young, poor Black men, the article helps advocate for a better understanding of other types of lethal violence that affect women, LGBQTI and other minorities. The article calls for a better understanding of the role of the state, the police and other criminal justice actors as generators and/or controllers of violence, as well as the need for other perspectives on homicide prevention, which include the microsituational aspects of killing, organized crime, and interaction between the individual and the environment.