Does presence of adenomyosis affect reproductive outcome in IVF cycles? A retrospective analysis of 973 patients

Sharma, Sunita; Bathwal, Shikha; Agarwal, Nidhi; Chattopadhyay, Ratna; Saha, Indranil; Chakravarty, Baidyanath

doi:10.1016/j.rbmo.2018.09.014

Cited by 69 publications

(114 citation statements)

References 30 publications

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“…The prevalence of sonographically detected adenomyosis in this study population of infertile patients is in accordance with the prevalence of 6.9–24.4% reported in other studies 12–15,17,20 . While there are no uniform guidelines regarding US diagnosis of adenomyosis, the selected features reflect those identified by the MUSA consensus group as being associated with adenomyosis 7,21 .…”

Section: Discussionsupporting

confidence: 90%

Three‐dimensional ultrasound diagnosis of adenomyosis is not associated with adverse pregnancy outcome following single thawed euploid blastocyst transfer: prospective cohort study

Neal

Morin

Werner

et al. 2020

Ultrasound in Obstet & Gyne

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This is the first prospective study to evaluate the impact of adenomyosis on pregnancy outcome following frozen embryo transfer, finding that asymptomatic adenomyosis is not associated with adverse pregnancy outcome in this setting. In addition, it provides information regarding the reproducibility of three-dimensional ultrasound diagnosis of adenomyosis. What are the clinical implications of this work? These findings suggest that routine screening for asymptomatic adenomyosis in an unselected infertile patient population undergoing frozen embryo transfer is not warranted.

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Section: Discussionsupporting

confidence: 90%

Three‐dimensional ultrasound diagnosis of adenomyosis is not associated with adverse pregnancy outcome following single thawed euploid blastocyst transfer: prospective cohort study

Neal

Morin

Werner

et al. 2020

Ultrasound in Obstet & Gyne

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“…In particular, compared with women with endometriosis alone, those affected by adenomyosis had a significantly lower clinical pregnancy rate (26.4% versus 12.5%) and live-birth rate (26.4% versus 12.5%). Similar results were reported in women with endometriosis and adenomyosis 71 .…”

Section: Impact On Fertilitysupporting

confidence: 89%

Recent advances in understanding and managing adenomyosis

2019

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Adenomyosis is a benign uterine disorder in which endometrial glands and stroma are pathologically demonstrated in the uterine myometrium and it is considered a specific entity in the PALM-COEIN FIGO (polyp; adenomyosis; leiomyoma; malignancy and hyperplasia; coagulopathy; ovulatory dysfunction; endometrial; iatrogenic; and not yet classified – International Federation of Gynecology and Obstetrics) classification of causes of abnormal uterine bleeding (AUB). Although it has always been considered the classic condition of multiparous women over 40 years old who have pain and heavy menstrual bleeding, diagnosed at hysterectomy, the epidemiological scenario has completely changed. Adenomyosis is increasingly identified in young women with pain, AUB, infertility, or no symptoms by using imaging techniques such as transvaginal ultrasound and magnetic resonance. However, there is no agreement on the definition and classification of adenomyotic lesions from both the histopathology and the imaging point of view, and the diagnosis remains difficult and unclear. A uniform and shared reporting system needs to be implemented in order to improve our understanding on imaging features, their relationship with pathogenic theories, and their importance in terms of clinical symptoms and response to treatment. In fact, adenomyosis pathogenesis remains elusive and not a single theory can explain all of the different phenotypes of the disease. Furthermore, adenomyosis often coexists with other gynecological conditions, such as endometriosis and uterine fibroids, increasing the heterogeneity of available data. Treatment requires a lifelong management plan as the disease has a negative impact on quality of life in terms of menstrual symptoms, fertility, and pregnancy outcome and has a high risk of miscarriage and obstetric complications.

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“…For instance, polycystic ovary syndrome (PCOS) has been recognized as an endocrine disease related to the increased risk of adverse perinatal outcomes [14, 15]. Sharma et al found that the presence of adenomyosis might contribute to the adverse effects on the IVF outcomes in terms of the clinical pregnancy rate, live birth rate and miscarriage rate [16]. Additionally, Wang LF et al suggested that pre-pregnancy obesity might result in the high prevalence of macrosomia, which increased the mean BW in cohort analysis [17].…”

Section: Discussionmentioning

confidence: 99%

Neonatal outcomes of singleton live births with vanishing twin syndrome following double embryos transfer in assisted reproductive technology: a retrospective cohort study

et al. 2019

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Background Women with vanishing twin syndrome are associated with increased risks of adverse neonatal outcomes, such as preterm birth (PTB) and low birthweight (LBW), compared with those in singleton live births following single embryo transfer (SET) in assisted reproductive technology (ART). Methods Anonymized data on all cycles performed in China were obtained from the Reproductive Medicine Department at the Third Affiliated Hospital of Zhengzhou University, which had involved 127597 cycles following double embryos transfer (DET), including 54585 fresh embryos transfer (ET) cycles and 73012 frozen embryos transfer (FET) cycles. In addition, the obstetric outcomes, such as gestation age, PTB, small for gestation age (SGA), birthweight (BW), LBW, congenital malformation, pediatric admission and Neonatal Intensive Care Unit (NICU) admission in the fresh ET and FET cycles, were analyzed. Moreover, logistic regression analysis was performed to adjust the confounders, including age of women, body weight index (BMI), value of AMH, infertile years, current cycle, antral follicles, cause of infertility, number of oocytes retrieved, endometrial thickness at the date of transplantation, number of high-quality embryos, and embryo stage. Results In the fresh ET cycles, the BW and gestational age in study group were lower than those in control group, which were (2962.4 ± 563.1vs. 3104.9 ± 498. 5, p = 0.000) and (262.8 ± 8.4 vs. 268.9 ± 13.9, p = 0.000), respectively. Relative to control group, the study group was linked with increased risks of PTB (adjusted odds ratio (aOR) 2.45, 95% CI:1.98–3.03, adjusted p = 0.000), LBW (aOR2.11, 95% CI:1.67–2.65, adjusted p = 0.000), pediatric admission (aOR 2.55, 95% CI2.07–3.13, adjusted p = 0.000), and NICU admission (aOR 1.98, 95% CI1.32–2.96, adjusted p = 0.001), but there were no statistically significant differences in the risks of SGA (aOR 1.09, 95% CI0.82–1.45, adjusted p = 0.960) and congenital malformation (aOR 0.94, 95% CI0.53–1.68, adjusted p = 0.640) between the two groups. In the FET cycles, the gestational age and BW in study group were lower than those in control group, which were (263.0 ± 15.7vs. 273.0 ± 10.5, p = 0.000) and (3099 ± 662.1vs. 3352 ± 671.5), respectively. The study group was associated with increased risks of PTB (aOR2. 45, 95% CI: 2.23–3.43, adjusted p = 0.000), LBW (aOR 2.67, 95% CI: 2.13–3.34, adjusted p = 0.000), pediatric admission (aOR2.62, 95% CI2.14–3.21, adjusted p = 0.000), and NICU admission (aOR 2.22, 95% CI1.43, 3.46, adjusted p = 0.001) compared with those in control group, but differences in the risks of SGA (aOR 0.98, 95...

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Does presence of adenomyosis affect reproductive outcome in IVF cycles? A retrospective analysis of 973 patients

Cited by 69 publications

References 30 publications

Three‐dimensional ultrasound diagnosis of adenomyosis is not associated with adverse pregnancy outcome following single thawed euploid blastocyst transfer: prospective cohort study

Three‐dimensional ultrasound diagnosis of adenomyosis is not associated with adverse pregnancy outcome following single thawed euploid blastocyst transfer: prospective cohort study

Recent advances in understanding and managing adenomyosis

Neonatal outcomes of singleton live births with vanishing twin syndrome following double embryos transfer in assisted reproductive technology: a retrospective cohort study

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