Does Providing Previous Results Change the Accuracy of Cervical Cytology?

Davey, Elizabeth; Irwig, Les; Macaskill, Petra; Clarke, Joanne M.; Thurloe, Julia K.; Hyne, Suzanne; Biro, Clare

doi:10.1159/000325405

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…An ROC metric to summarize the ability of cervical (anal) cytology to discriminate between ≥CIN 2 (AIN 2) and < CIN 2 (AIN 2) histology has been previously used [10]–[12] and has the advantage of not being cut point dependent.…”

Section: Methodsmentioning

confidence: 99%

Comparative Accuracy of Anal and Cervical Cytology in Screening for Moderate to Severe Dysplasia by Magnification Guided Punch Biopsy: A Meta-Analysis

2011

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BackgroundThe accuracy of screening for anal cancer precursors relative to screening for cervical cancer precursors has not been systematically examined. The aim of the current meta-analysis was to compare the relative accuracy of anal cytology to cervical cytology in discriminating between histopathologic high grade and lesser grades of dysplasia when the reference standard biopsy is obtained using colposcope magnification.Methods and FindingsThe outcome metric of discrimination was the receiver operating characteristic (ROC) curve area. Random effects meta-analysis of eligible studies was performed with examination of sources of heterogeneity that included QUADAS criteria and selected covariates, in meta-regression models. Thirty three cervical and eleven anal screening studies were found to be eligible. The primary meta-analytic comparison suggested that anal cytologic screening is somewhat less discriminating than cervical cytologic screening (ROC area [95% confidence interval (C.I.)]: 0.834 [0.809–0.859] vs. 0.700 [0.664–0.735] for cervical and anal screening, respectively). This finding was robust when examined in meta-regression models of covariates differentially distributed by screening setting (anal, cervical).ConclusionsAnal cytologic screening is somewhat less discriminating than cervical cytologic screening. Heterogeneity of estimates within each screening setting suggests that other factors influence estimates of screening accuracy. Among these are sampling and interpretation errors involving both cytology and biopsy as well as operator skill and experience.

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Section: Methodsmentioning

confidence: 99%

Comparative Accuracy of Anal and Cervical Cytology in Screening for Moderate to Severe Dysplasia by Magnification Guided Punch Biopsy: A Meta-Analysis

2011

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Inadequate clinical data on Pap test request form: Where are we headed in the era of precision medicine?

Kumar

Gupta

2020

Cytojournal

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The request form accompanying any sample to a clinical laboratory constitutes an important communication tool between the clinician and the laboratory personnel. Much has been written about the inadequacy of pertinent clinical data on the request slips for hematology and biochemistry tests and its impact on the subsequent test interpretation and error liability. Although the cytology laboratories, including those performing cervical cytology, have to deal with a similar problem of lack of clinical information critical to the proper interpretation of cytomorphologic features, the issue has not been attended to or reported adequately in the literature. This article attempts to explore this topic of inadequate clinical data on Pap test request form from multiple perspectives and suggest possible ways to circumvent this age-old problem. These recommendations may be tailor-made and adopted as per the individual laboratory’s logistics.

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Does Providing Previous Results Change the Accuracy of Cervical Cytology?

Cited by 2 publications

References 8 publications

Comparative Accuracy of Anal and Cervical Cytology in Screening for Moderate to Severe Dysplasia by Magnification Guided Punch Biopsy: A Meta-Analysis

Comparative Accuracy of Anal and Cervical Cytology in Screening for Moderate to Severe Dysplasia by Magnification Guided Punch Biopsy: A Meta-Analysis

Inadequate clinical data on Pap test request form: Where are we headed in the era of precision medicine?

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