Does pursuit abnormality in schizophrenia represent a deficit in the predictive mechanism?

Thaker, Gunvant K.; Ross, David E.; Boyer, Robert; Moran, Marianne; Lahti, Adrienne C.; Kim, Chul; Medoff, Deborah R.

doi:10.1016/0165-1781(95)02759-9

Cited by 41 publications

(36 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This effect was not related to minimal treatment-emergent EPS or to changes in manual motor control, suggesting that the ability to generate accurate behavioral responses based on internal representations without sensory feedback is a process adversely and selectively impacted by risperidone treatment. The demonstration of reduced accuracy of predictive saccades after treatment is consistent with findings from prior studies with medicated patients (Crawford et al, 1995a;Hommer et al, 1991;McDowell et al, 1996;Thaker et al, 1996). However, the present findings are the first to document the onset of this robust deficit after the initiation of antipsychotic therapy.…”

Section: Discussionsupporting

confidence: 81%

“…Previous studies investigating predictive saccades in schizophrenia all documented hypometric (ie undershooting) predictive saccades in medicated, typically chronic schizophrenia patients (Crawford et al, 1995a;Hommer et al, 1991;McDowell et al, 1996;Thaker et al, 1996). Findings with regard to the ability to learn to accurately time predictive saccades in relation to stimulus appearance have been less consistent.…”

Section: Introductionmentioning

confidence: 84%

“…Findings with regard to the ability to learn to accurately time predictive saccades in relation to stimulus appearance have been less consistent. McDowell et al (1996) reported faster response latencies, Thaker et al (1996) reported slower latencies, and Crawford et al (1995a) found no latency differences between schizophrenia and healthy groups. In a combined group of antipsychotic-free and antipsychotic-naive schizophrenia patients, Krebs et al (2001) reported hypometric predictive saccades, as did Hutton et al (2001) in a group of never-medicated patients.…”

Section: Introductionmentioning

confidence: 91%

See 2 more Smart Citations

Effects of Risperidone on Procedural Learning in Antipsychotic-Naive First-Episode Schizophrenia

Harris

Wiseman

Reilly

et al. 2008

Neuropsychopharmacol

View full text Add to dashboard Cite

Studies of procedural learning in medicated schizophrenia patients using predictive saccade paradigms have consistently demonstrated hypometric predictive responses. Findings from antipsychotic-naive schizophrenia patients indicate fewer or no deficits. This pattern of findings suggests that antipsychotic medications might adversely affect frontostriatal systems supporting procedural learning on this task. The accuracy and latency of predictive saccades were assessed in 25 antipsychotic-naive first-episode schizophrenia patients and 22 matched healthy individuals. Patients were retested after 6 weeks of treatment with risperidone. Healthy individuals were reevaluated after a similar time period. The ability to learn to time response initiation in anticipation of target appearance (target prediction) was not impaired in patients before or after treatment. In contrast, although no deficits were evident before treatment initiation, after treatment patients showed a marked decrease in the accuracy of predictive but not sensory-guided responses. The findings from pretreatment testing indicate that procedural learning is a relatively unaffected cognitive domain in antipsychotic-naive first-episode schizophrenia. Although treatment-emergent extrapyramidal symptoms were minimal, these data suggest that D2 antagonism in striatum after risperidone treatment was sufficiently robust to disrupt the generation of planned volitional behavior guided by internalized representations.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 91%

See 1 more Smart Citation

Effects of Risperidone on Procedural Learning in Antipsychotic-Naive First-Episode Schizophrenia

Harris

Wiseman

Reilly

et al. 2008

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Recent studies have suggested that failures in continuous CD might underlie the robust smooth pursuit impairments (Hong et al 2003(Hong et al , 2005Lindner et al 2005;Nkam et al 2010;Spering et al 2013;Thaker et al 1996) and larger shifts in perisaccadic localization of visual stimuli in SZP (Richard et al 2014). Our findings suggest that SZP are also impaired in generating and/or using the transient CD signals that accompany saccadic eye movements (Sommer and Wurtz 2004).…”

Section: Discussionmentioning

confidence: 49%

Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia

Rösler

Rolfs

Stigchel

et al. 2015

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

“…The brightness of the cues and of the target (measured with a Minolta Spotmeter M set at 100 ASA, placed 60 cm from the monitor) was 0.33 and 0.16 footlamberts, respectively. Eye movements were monitored with the infrared technique (34), and data from subjects who showed saccadic eye movements that overlapped the cue-target interval in more than 5% of the trials were excluded. On each testing occasion, the subject completed eight blocks of 64 trials (total=512) preceded by 25 practice trials.…”

Section: Cognitive Testingmentioning

confidence: 99%

Visual information-processing impairments in deficit and nondeficit schizophrenia

Bustillo

Thaker²,

Boyer³

et al. 1997

AJP

View full text Add to dashboard Cite

(2) and may represent a trait characteristic of the disorder (3). Attentional abnormalities have been found in unaffected relatives of persons with schizophrenia and in populations with subclinical dysfunctions thought to form part of the "schizophrenia spectrum" (3). Nevertheless, attention is not a unitary construct, and schizophrenia is most likely a heterogeneous disease; therefore it is unclear which aspects of attention are compromised in patients with schizophrenia and whether the impairment is related to a particular subgroup or symptom domain.A particular type of selective attention, covert visuospatial attention, has been studied in normal subjects and in persons with brain lesions by means of a simple reaction time task (4). In the covert visuospatial attention test, "covert" (as opposed to "overt") refers to shifts of attention in the absence of eye movements. These studies have shown that cueing attention to a visual location has consistent benefits and costs with respect to efficiency in detecting targets, depending on whether the cue accurately predicts the location of the target (i.e., is a valid cue; invalid cues orient the subject to the opposite side). Subjects with posterior parietal lesions have exhibited increased reaction times when detecting a target on the contralesional hemifield only if attention was initially cued to the ipsilesional hemifield (4). This increased cost from invalid cues, with normal benefit from valid cues, has been interpreted as an impairment in the function for disengaging covert visuospatial attention. Impairment in the two other covert visuospatial attention functions, shift and engage, have been related to midbrain lesions (5) and thalamic lesions (6), respectively. The covert visuospatial attention paradigm offers several advantages for the study of attention in schizophrenia. 1) Unlike many neuropsychological tests, it has dissectible cognitive operations (disengage, shift, engage), 2) it is thought to involve discrete neural systems, and 3) it allows for evaluation of asymmetric performance within subjects and for

show abstract

Does pursuit abnormality in schizophrenia represent a deficit in the predictive mechanism?

Cited by 41 publications

References 32 publications

Effects of Risperidone on Procedural Learning in Antipsychotic-Naive First-Episode Schizophrenia

Effects of Risperidone on Procedural Learning in Antipsychotic-Naive First-Episode Schizophrenia

Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia

Visual information-processing impairments in deficit and nondeficit schizophrenia

Contact Info

Product

Resources

About