Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia

Rösler, Lara; Rolfs, Martin; Stigchel, Stefan Van der; Neggers, Sebastiaan F. W.; Cahn, Wiepke; Kahn, René S.; Thakkar, Katharine N.

doi:10.1152/jn.00155.2015

Cited by 31 publications

(36 citation statements)

References 34 publications

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“…Also, as suggested by Figure 10, disruption of transthalamic pathways would likely lead to efference copy deficiencies. Indeed, this is precisely what is seen with schizophrenic patients: they have a variety of symptoms related to defective efference copy (44,45,126,133,158). Generally speaking, we suggest that this new concept involving transthalamic cortical pathways will prove critical in further understanding of cortical functioning in many areas of cognition, learning, memory, and attention, and also may prove a useful hypothetical framework against which to consider thalamic deficits in various clinical conditions such as schizophrenia.…”

Section: Relationship To Schizophreniamentioning

confidence: 68%

Functioning of Circuits Connecting Thalamus and Cortex

Sherman¹

2017

Comprehensive Physiology

133

108

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Glutamatergic pathways in thalamus and cortex are divided into two distinct classes: driver, which carries the main information between cells, and modulator, which modifies how driver inputs function. Identifying driver inputs helps to reveal functional computational circuits, and one set of such circuits identified by this approach are cortico-thalamo-cortical (or transthalamic corticocortical) circuits. This, in turn, leads to the conclusion that there are two types of thalamic relay: first order nuclei (such as the lateral geniculate nucleus) that relay driver input from a subcortical source (i.e., retina), and higher order nuclei (such as the pulvinar) which are involved in these transthalamic pathways by relaying driver input from layer 5 of one cortical area to another. This thalamic division is also seen in other sensory pathways and beyond these so that most of thalamus by volume consists of higher-order relays. Many, and perhaps all, direct driver connections between cortical areas are paralleled by an indirect cortico-thalamo-cortical (transthalamic) driver route involving higher order thalamic relays. Such thalamic relays represent a heretofore unappreciated role in cortical functioning, and this assessment challenges and extends conventional views regarding both the role of thalamus and mechanisms of corticocortical communication. Finally, many and perhaps the vast majority of driver inputs relayed through thalamus arrive via branching axons, with extrathalamic targets often being subcortical motor centers. This raises the possibility that inputs relayed by thalamus to cortex also serve as efference copies, and this may represent an important feature of information relayed up the cortical hierarchy via transthalamic circuits. © 2017 American Physiological Society. Compr Physiol 7:713-739, 2017.

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Section: Relationship To Schizophreniamentioning

confidence: 68%

Functioning of Circuits Connecting Thalamus and Cortex

Sherman¹

2017

Comprehensive Physiology

133

108

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“…Consistent with this notion, CD abnormalities have been observed in individuals with bipolar disorder who have a history of psychotic symptoms [45, 46] and in healthy individuals with schizophrenia-like traits [47, 48]. Although there is some evidence for a relationship between psychotic symptom severity and CD alterations in schizophrenia [29, 35, 39], these relationships are inconsistent across studies. Indeed, many studies of CD find no such relationship, leaving open the possibility that altered CD is related to other clinical factors in schizophrenia and bipolar disorder.…”

Section: Evidence For Disturbed Oculomotor CD In Psychosismentioning

confidence: 98%

“…This task relies on CD to inform the visual system of the vector of the executed saccade. Altered CD, therefore, may cause impaired post-saccadic localization of visual targets in schizophrenia patients [39]. Two further studies investigated mislocalization of visual targets flashed around the time of a saccade, but their implications are unclear.…”

Section: Evidence For Disturbed Oculomotor CD In Psychosismentioning

confidence: 99%

Oculomotor Prediction: A Window into the Psychotic Mind

Thakkar

Diwadkar

Rolfs

2017

Trends in Cognitive Sciences

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Psychosis—an impaired contact with reality—is a hallmark of schizophrenia. Many psychotic symptoms are associated with disruptions in agency—the sense that I cause my actions. A failure to predict sensory consequences of one’s own actions may underlie agency disturbances. Such predictions rely on corollary discharge (CD) signals, “copies” of movement commands sent to sensory regions prior to action execution. Here, we make a case that the oculomotor system is a promising model for understanding CD in psychosis, building on advances in our understanding of the behavioral and neurophysiological correlates of CD associated with eye movements. We provide an overview of recent evidence for disturbed oculomotor CD in schizophrenia, potentially linking bizarre and disturbing psychotic experiences with basic physiological processes.

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“…Thakkar et al, 2015; Ford et al, 2014; Ford and Mathalon, 2012). However, evidence for an association between corollary discharge and specific symptoms, such as auditory hallucinations, is mixed (Rosler et al, 2015; Ford and Mathalon, 2012). The neural mechanisms underlying efferent copy and corollary discharge are incompletely understood; however, human (Ostendorf et al, 2013) and non-human primate (Cavanaugh et al, 2016; Sommer and Wurtz, 2008) studies have linked the thalamus, especially the mediodorsal nucleus, to corollary discharge.…”

Section: 0 Thalamocortical Pathology In Schizophrenia: Contributiomentioning

confidence: 99%

Review of thalamocortical resting-state fMRI studies in schizophrenia

Giraldo‐Chica

Woodward

2017

Schizophrenia Research

188

113

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Brain circuitry underlying cognition, emotion, and perception is abnormal in schizophrenia. There is considerable evidence that the neuropathology of schizophrenia includes the thalamus, a key hub of cortical-subcortical circuitry and an important regulator of cortical activity. However, the thalamus is a heterogeneous structure composed of several nuclei with distinct inputs and cortical connections. Limitations of conventional neuroimaging methods and conflicting findings from post-mortem investigations have made it difficult to determine if thalamic pathology in schizophrenia is widespread or limited to specific thalamocortical circuits. Resting-state fMRI has proven invaluable for understanding the large-scale functional organization of the brain and investigating neural circuitry relevant to psychiatric disorders. This article summarizes resting-state fMRI investigations of thalamocortical functional connectivity in schizophrenia. Particular attention is paid to the course, diagnostic specificity, and clinical correlates of thalamocortical network dysfunction.

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Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia

Abstract: Rösler L, Rolfs M, van der Stigchel S, Neggers SF, Cahn W, Kahn RS, Thakkar KN. Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia.

Cited by 31 publications

References 34 publications

Functioning of Circuits Connecting Thalamus and Cortex

Functioning of Circuits Connecting Thalamus and Cortex

Oculomotor Prediction: A Window into the Psychotic Mind

Review of thalamocortical resting-state fMRI studies in schizophrenia

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