Review of thalamocortical resting-state fMRI studies in schizophrenia

Giraldo‐Chica, Mónica; Woodward, Neil D.

doi:10.1016/j.schres.2016.08.005

Cited by 187 publications

(138 citation statements)

References 92 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…In our analysis, the most affected regions and domains include the thalamus of the subcortical domain; BA 38 of the attention domain; the left insula, left BA 44, right BAs 41/42 and the rostral area of left BA 22 of the language domain; and the fusiform gyrus, medioventral, and lateral occipital cortex of the visual domain. The thalamus is known as a major brain structure affected both structurally and functionally in patients with SZ (Cheng et al, 2015; Damaraju et al, 2014; Giraldo-Chica and Woodward, 2017). Disruption in attention associated areas is frequently reported in patients with schizophrenia (Bowie and Harvey, 2006).…”

Section: Discussionmentioning

confidence: 99%

Spatial dynamics within and between brain functional domains: A hierarchical approach to study time‐varying brain function

Iraji

Damaraju

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

The analysis of time-varying activity and connectivity patterns (i.e., the chronnectome) using resting-state magnetic resonance imaging has become an important part of ongoing neuroscience discussions. The majority of previous work has focused on variations of temporal coupling among fixed spatial nodes or transition of the dominant activity/connectivity pattern over time. Here, we introduce an approach to capture spatial dynamics within functional domains (FD), as well as temporal dynamics within and between FD. The approach models the brain as a hierarchical functional architecture with different levels of granularity, where lower levels have higher functional homogeneity and less dynamic behavior and higher levels have less homogeneity and more dynamic behavior. First, a high-order spatial independent component analysis is used to approximate functional units. A functional unit is a pattern of regions with very similar functional activity over time. Next, functional units are used to construct FDs. Finally, functional modules (FMs) are calculated from FDs, providing an overall view of brain dynamics. Results highlight the spatial fluidity within FDs, including a broad spectrum of changes in regional associations from strong coupling to complete decoupling. Moreover, FMs capture the dynamic interplay between FDs. Patients with schizophrenia show transient reductions in functional activity and state connectivity across several FDs, particularly the subcortical domain. Activity and connectivity differences convey unique information in many cases (e.g. the default mode) highlighting their complementarity information. The proposed hierarchical model to capture FD spatiotemporal variation provides new insight into the macroscale chronnectome and identifies changes hidden from existing approaches.

show abstract

Section: Discussionmentioning

confidence: 99%

Spatial dynamics within and between brain functional domains: A hierarchical approach to study time‐varying brain function

Iraji

Damaraju

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Sleep spindles are generated from the reticular thalamic nucleus, particularly during NREM sleep, and several previous studies have documented dysconnectivity in the thalamo‐cortical networks in patients with schizophrenia (Giraldo‐Chica & Woodward, ). Reports of clinical correlates of thalamo‐cortical dysconnectivity in schizophrenia have been inconsistent, but a relation to symptom severity has been described (Cheng et al., ).…”

Section: Discussionmentioning

confidence: 99%

Investigation of sleep spindle activity and morphology as predictors of neurocognitive functioning in medicated patients with schizophrenia

Baandrup

Christensen

Fagerlund

et al. 2018

Journal of Sleep Research

View full text Add to dashboard Cite

Neurocognitive impairment is a trait marker of schizophrenia, but no effective treatment has yet been identified. Sleep spindle deficits have been associated with diminished sleep-dependent memory learning. We examined whether this link could be extended into various cognitive domains by investigating the association of a neurocognitive test battery (the Brief Assessment of Cognition in Schizophrenia) with sleep spindle activity and morphology. We examined 37 outpatients diagnosed with schizophrenia and medicated with both antipsychotics and benzodiazepines. Participants underwent 1 night polysomnography and test of neurocognitive functioning. We identified and analysed sleep spindles in all non-rapid eye movement sleep and in non-rapid eye movement sleep stage 2 in a central electroencephalography channel using an automatic sleep spindle detector previously validated. Slow sleep spindle density was computed from a frontal electroencephalography channel as well. We found no association between cognitive functioning and sleep spindle density or sleep spindle morphology for spindles in non-rapid eye movement sleep when controlling for gender, age, symptom severity, and daily dose of antipsychotics and benzodiazepines. For spindles in non-rapid eye movement sleep stage 2, we found that motor speed was associated with frontal slow sleep spindle density. We conclude that frontal slow spindle density might predict motor speed in medicated patients with schizophrenia, but that no other sleep spindle activity or sleep spindle morphology measures were predictors of neurocognitive functioning.

show abstract

“…Experimental evidence has suggested that, during liver fibrosis and cirrhosis, the process of angiogenesis is associated with the progress of hepatic fibrogenesis [19]. Interestingly, pathological angiogenesis contributes to HSC activation causing liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Plumbagin Alleviates Capillarization of Hepatic Sinusoids In Vitro by Downregulating ET-1, VEGF, LN, and Type IV Collagen

Peng

Zhao

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

Critical roles for liver sinusoidal endothelial cells (LSECs) in liver fibrosis have been demonstrated, while little is known regarding the underlying molecular mechanisms of drugs delivered to the LSECs. Our previous study revealed that plumbagin plays an antifibrotic role in liver fibrosis. In this study, we investigated whether plumbagin alleviates capillarization of hepatic sinusoids by downregulating endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), laminin (LN), and type IV collagen on leptin-stimulated LSECs. We found that normal LSECs had mostly open fenestrae and no organized basement membrane. Leptin-stimulated LSECs showed the formation of a continuous basement membrane with few open fenestrae, which were the features of capillarization. Expression of ET-1, VEGF, LN, and type IV collagen was enhanced in leptin-stimulated LSECs. Plumbagin was used to treat leptin-stimulated LSECs. The sizes and numbers of open fenestrae were markedly decreased, and no basement membrane production was found after plumbagin administration. Plumbagin decreased the levels of ET-1, VEGF, LN, and type IV collagen in leptin-stimulated LSECs. Plumbagin promoted downregulation of ET-1, VEGF, LN, and type IV collagen mRNA. Altogether, our data reveal that plumbagin reverses capillarization of hepatic sinusoids by downregulation of ET-1, VEGF, LN, and type IV collagen.

show abstract

Review of thalamocortical resting-state fMRI studies in schizophrenia

Cited by 187 publications

References 92 publications

Spatial dynamics within and between brain functional domains: A hierarchical approach to study time‐varying brain function

Spatial dynamics within and between brain functional domains: A hierarchical approach to study time‐varying brain function

Investigation of sleep spindle activity and morphology as predictors of neurocognitive functioning in medicated patients with schizophrenia

Plumbagin Alleviates Capillarization of Hepatic Sinusoids In Vitro by Downregulating ET-1, VEGF, LN, and Type IV Collagen

Contact Info

Product

Resources

About