Does Quantitative Histology of Rectal Biopsy Improve the Differential Diagnosis of Crohn's Disease and Ulcerative Colitis in Adults?

Schmitz-Moormann, P; Himmelmann, G. W.

doi:10.1016/s0344-0338(88)80097-9

Cited by 25 publications

(20 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This percentage was also higher than those found by several studies (6,15,20,21,27,28) in which the correlation was 94%, 80%, 75%, 72%, 73%, and 73% respectively. Our hypothesis that the standardized histopathological diagnosis increases the correlation with the gold standard in IBD was supported on two other studies (3,13) .…”

Section: Discussioncontrasting

confidence: 63%

See 1 more Smart Citation

Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?

Baldin¹,

Telles²,

Bonardi³

et al. 2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

View full text Add to dashboard Cite

Introduction: Inflammatory bowel disease comprises two major categories: Crohn's disease and ulcerative rectocolitis, both with different clinical and histological aspects, causing sometimes significant morbidity. Objectives: Choose and apply standardized and quantified histopathological diagnosis method, and compare the results and quality index with the original diagnosis. Materials and methods: 43 histological colonoscopic biopsies of 37 patients were re-evaluated by standardized system. Results and discussion: The original diagnoses were more inconclusive (23.3%) than those standardized (2.3%). The agreement with gold standard (clinical, colonoscopical, and radiological diagnosis) was higher on standardized diagnoses (95.3%) than in original (74.4%), especially in relation to Crohn's disease, which percentages were 92.3% and 46.1%, respectively. The quality index was calculated in conclusive diagnosis of each method. For ulcerative rectocolitis, both methods showed sensitivity and negative predictive value of 100%; otherwise the original diagnosis demonstrated specificity of 85.7%, positive predictive value of 96.3% and accuracy of 97.0%, and the standardized diagnosis 92.3%, 96.7% and 97.6%, respectively. For Crohn's disease, there is specificity and positive predictive value of 100% in both methods; the original diagnosis showed sensitivity of 85.7%, negative predictive value of 96.3% and accuracy of 97%, while for the standardized diagnoses 92.3%, 96.7%, and 97.6%, respectively. Conclusion: The standardized diagnosis presented a higher percentage of correct and conclusive diagnoses than those presented in the original diagnosis, especially for Crohn's disease, as well as equal or slightly higher values in some quality index.

show abstract

Section: Discussioncontrasting

confidence: 63%

“…27,28) . Paneth metaplasia (Figure 3) was not analyzed in some studies (13,20,21) , but was analyzed and considered important in six other studies (6,(24)(25)(26)(27)(28) . In the studies reviewed, the histopathological findings were evaluated taking into account different criteria.…”

Section: Figure 2b -Crypt Atrophy Characterized By Tortuosity Scarcimentioning

confidence: 99%

Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?

Baldin¹,

Telles²,

Bonardi³

et al. 2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

View full text Add to dashboard Cite

show abstract

“…Neutrophils present in the intestinal crypt are a feature of cryptitis 47. An increase in eosinophils in the lamina propria has been observed in UC; however, as eosinophil are a general sign of inflammation, they are also present in other forms of colitis 48. Conversely, the presence of well-formed epithelioid granulomas in the lamina propria support a diagnosis of CD over UC 49.…”

Section: Resultsmentioning

confidence: 99%

Management of ulcerative colitis in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease

et al. 2017

View full text Add to dashboard Cite

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic mucosal inflammation of the colon, and the prevalence and incidence of UC have been steadily increasing in Taiwan. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of UC taking into account currently available evidence and the expert opinion of the committee. Accurate diagnosis of UC requires thorough clinical, endoscopic, and histological assessment and careful exclusion of differential diagnoses, particularly infectious colitis. The goals of UC therapy are to induce and maintain remission, reduce the risk of complications, and improve quality of life. As outlined in the recommended treatment algorithm, choice of treatment is dictated by severity, extent, and course of disease. Patients should be evaluated for hepatitis B virus and tuberculosis infection prior to immunosuppressive treatment, especially with steroids and biologic agents, and should be regularly monitored for reactivation of latent infection. These consensus statements are also based on current local evidence with consideration of factors, and could be serve as concise and practical guidelines for supporting clinicians in the management of UC in Taiwan.

show abstract

“…For these conditions, morphological studies have mainly been concentrated on features which are reliable for the diagnosis of IBD. [7][8][9][10][11][12][13][14][15][16][17][18][19] Severity and activity of the disease are usually measured with clinical and biological parameters occasionally supplemented with endoscopic indices. [20][21][22][23][24] Whether microscopic disease activity is important for the clinical course of the disease has not yet been established adequately.…”

mentioning

confidence: 99%

Influence of treatment on morphological features of mucosal inflammation

Geboes

Dalle

2002

Gut

122

View full text Add to dashboard Cite

Does Quantitative Histology of Rectal Biopsy Improve the Differential Diagnosis of Crohn's Disease and Ulcerative Colitis in Adults?

Cited by 25 publications

References 9 publications

Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?

Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?

Management of ulcerative colitis in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease

Influence of treatment on morphological features of mucosal inflammation

Contact Info

Product

Resources

About