Does sex of the patient play a role in survival for MSI colorectal cancer?

Tulin, Adrian; Slavu, Iulian; Tulin, Raluca; Aleçu, Lucian; Jecan, Cristian Radu; Orlov, Cristina; Iaciu, Cristian; Stănculeanu, Dana Lucia; Hainăroşie, Răzvan; Pițuru, Silviu; Stoian, Anca Pantea; Nițipir, Cornelia

doi:10.22543/7674.51.p101108

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…OSCC is more common among males than females, with a ratio ranging from 2:1 to 4:1 (22). Thus, only male subjects were included in this study (patients and control groups) to avoid inter sex-related variations (25,26).…”

Section: Patientsmentioning

confidence: 99%

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

et al. 2019

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Melatonin, the primary hormone produced by the pineal gland, is intensely assessed for its anticancer properties. This study aimed to reveal the clinical significance of serum melatonin levels in predicting the severity of oral squamous cell carcinoma (OSCC). For this purpose, 40 male patients with OSCC and 30 healthy subjects were enrolled in this study. The serum levels of melatonin were determined by ELISA. The results revealed that the melatonin concentrations were significantly lower in the patients with OSCC compared with the controls (18.2 vs. 47.6 pg/ml, P<0.001). In addition, the serum melatonin levels had a high predictive accuracy for discriminating patients with OSCC with T-depth of invasion (DOI) II from the healthy controls (89.1%), as well as in discriminating patients with OSCC with nodal metastasis from those without nodal metastasis (83.8%). On the whole, the findings of this study suggest that the serum melatonin concentrations are closely related to the severity of OSCC and may thus be used to assess the different stages of oral cancer objectively and accurately. The present study also supports the conclusion that melatonin may be a potential therapeutic agent for use in the treatment of patients with OSCC.

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Section: Patientsmentioning

confidence: 99%

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

et al. 2019

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“…The overall greater incidence of CRC in men corresponds to the data in the literature. [9]It is not fully known why CRC affects men more than women, but this may be explained by the fact that men are more likely to exhibit exogenous risk factors (gender related behavior) such as: great alcohol consumption, smoking, red meat and processed food consumption, predisposition to deposit visceral fat. [10,11] According to the provenience of patients, from the total number of 763 patients diagnosed with CRC, 501 patients (65.66%) came from the urban area while 262 patients (34.33%) came from the rural area.…”

Section: Resultsmentioning

confidence: 99%

Five Years Retrospective Review of Colorectal Cancer Risk Factors in the Black Sea Coast Population

Micu¹,

Oraiopoulou²,

Manea³

et al. 2020

Rev. Chim.

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Considering its increasing incidence, complications, comorbidities, mortality and last but not least the tendency to decrease the age of onset, colorectal cancer (CRC) represents one of the significant concerns related to oncology diseases becoming in the last decades a public health problem. Although the etiology is not yet completely known, colorectal cancer is considered a disease with multiple factors, an important place occupying the impact of the environmental factors on the genetically particularly predisposition of patients. In order to reduce the incidence of this disease, screening methods have been developed that are addressed primarily to the population at risk and which have contributed significantly to reducing the occurrence of this condition. The purpose of this paper is to evaluate the presence of specific risk factors for CRC in the Black Sea Coast population for a period of 5 years, and to contribute to the reinforcement of some notions already well known in the specialized literature. By publishing this work, the committee of authors hopes to strengthen the profile of the individual at risk of developing CRC in order to identify better those that are in danger of developing this disease and refer them to screenin

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“…In contrast to 5-FU, sensitivity to oxaliplatin was independent of the MMR system in CRC cell lines [24][25][26]. The absence of BRAF mutation expression is a favorable prognostic factor [27,28].…”

Section: Clinical and Prognostic Features Of Msi-h Colorectal Tumorsmentioning

confidence: 99%

Immunohistochemical pattern– a prognostic factor for synchronous gastrointestinal cancer

Aliuș¹,

Cîrstoveanu²,

Badiu³

et al. 2020

JMMS

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Recent advancements in medical genetics and molecular biology are reflected in the modern understanding and approach to colorectal carcinoma (CRC). Understanding the cellular mechanisms and mutational patterns that promote carcinogenesis could enhance the predictive accuracy of the TNM classification. Furthermore, this will allow for a much more documented stratification and tailored oncological treatment. This paper presents an illustrative case of a relatively young patient (50 years old) with no family history of cancer who was diagnosed with four synchronous gastrointestinal (GI) adenocarcinomas displaying a wild type P53, negative BRAF testing, and mutated MLH1 and PMS2 proteins. This case report contributes to the relevant literature with a concise review of the role of micro-satellite instability (MSI), chromosomal instability (CIN), and CpG island methylator phenotype (CIMP) in carcinogenesis, hereditary and sporadic gastrointestinal cancers, a discussion over the importance of molecular subtyping in predicting long term outcomes and choosing the most suitable adjuvant treatment regimen.

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Does sex of the patient play a role in survival for MSI colorectal cancer?

Cited by 6 publications

References 23 publications

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

Five Years Retrospective Review of Colorectal Cancer Risk Factors in the Black Sea Coast Population

Immunohistochemical pattern– a prognostic factor for synchronous gastrointestinal cancer

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