Does Shilajit Have an Effect on New Bone Remodelling in the Rapid Maxillary Expansion Treatment? A Biochemical, Histopathological and Immunohistochemical Study

Abstract

Bu çalışmanın amacı sıçanlarda hızlı maksiller genişletme (RME) sonrası shilajit'in yeni kemik şekillenmesine etkilerini histopatolojik, biyokimyasal ve immünohistokimyasal teknikler kullanarak göstermektir. Gereç ve Yöntem Wistar Albino türü sıçanlar (12 haftalık) 3 farklı gruba ayrılmıştır (n = 8): üst çenede genişletme yapılmamış (NE), üst çenede sadece genişletme yapılmış (OE), üst çenede genişletmeye ilave olarak shilajit uygulanmış (Shilajit). Sıçanlara 5 günlük genişletme ve 12 günlük retansiyon periyodu süresince shilajit uygulandı. Hayvanlar sakrifiye edildikten sonra gerekli numuneler alınıp histopatolojik, biyokimyasal ve immünohistokimyasal analizler yapıldı. Bulgular Shilajit grubundaki glutatyon peroksidaz, süperoksit dismutaz ve katalaz düzeyleri OE grubundan daha yüksek bulundu (p <0.05). C telopeptid tip I kollajen ve kemik alkalen fosfataz seviyeleri gruplar arasında anlamlı farklılıklar gösterdi (p <0.001). İmmünohistokimyasal bulgular, OE grubunun shilajit grubundan anlamlı olarak daha fazla IL-1 ve TNF-α H skorlarına sahip olduğunu gösterdi (p <0.05). Tüm gruplar kılcal damar yoğunluğu, inflamatuar hücre infiltrasyonu ve yeni kemik oluşumu açısından karşılaştırıldığında gruplar arasında belirgin farklılıklar bulundu (p <0.05). Sonuç Shilajit'in sistemik kullanımı, midpalatal suturda yeni kemik şekillenmesini hızlandırarak, RME tedavisinden sonra nüksün önlenmesinde ve retansiyon süresini kısaltmada faydalı olabilir.

Review: Shilajit (Mumie) A natural Product with Anti-hyperglycemic, Anti-obesity, Anti-oxidant, and Anti-Inflammatory properties for a potential treatment of diabetes mellitus

“…In addition to Shilajit benefits for diabetes (Gupta et al, 2016;Raju & Sharma, 2016), it can also be beneficial for other diseases and conditions, including insulin resistance (Gupta, 1966;Kanikkannan et al, 1995), obesity (Patil et al, 2022;Pattonder et al, 2011), inflammation (Firozsalari et al;Pingali & Nutalapati, 2022), oxidative stress (Atashbar et al, 2018;Derhami et al, 2022), arthritis (Azizi et al, 2018;Lawley et al, 2013), cancer (Kloskowski et al, 2021;Pant et al, 2012), bone health (Cesur et al, 2019;Labban, 2013), allergy (Ghosal et al, 1989;Sadeghi et al, 2020), mental health (Jaiswal & Bhattacharya, 1992;Khaksari et al, 2013), immune system (Bižanov et al, 2012;Musthafa et al, 2018), increased energy (Bhattacharyya et al, 2009;Stohs et al, 2017), adaptogenic (Agarwal et al, 2007;Bansal & Banerjee, 2016), antiaging and rejuvenating (Ghosal, 1990;Wilson et al, 2011), and for sexual health (Ikram-ul-Haq et al, 2016;NİZAM & SELÇUK, 2021). These benefits are shown in table 2.…”

“…These benefits are shown in table 2. Research Reference/(s) Diseases/conditions (Gupta et al, 2016;Raju & Sharma, 2016) Diabetes (Ghezelbash et al, 2022;Kanikkannan et al, 1995) Insulin resistance (Patil et al, 2022;Pattonder et al, 2011) Obesity (Firozsalari et al;Pingali & Nutalapati, 2022) Inflammation (Atashbar et al, 2018;Derhami et al, 2022) Oxidative stress (Azizi et al, 2018;Lawley et al, 2013) Arthritis (Kloskowski et al, 2021;Pant et al, 2012) Cancer (Cesur et al, 2019;Labban, 2013) Bone health (Ghosal et al, 1989) Allergy (Jaiswal & Bhattacharya, 1992) Mental health (Bižanov et al, 2012;Musthafa et al, 2018) Immune system (Bhattacharyya et al, 2009;Stohs et al, 2017) Increase Energy (Agarwal et al, 2007;Bansal & Banerjee, 2016) Adaptogenic (adapt to stress) (Ghosal, 1990;Wilson et al, 2011) Anti-aging and rejuvenator (Ikram-ul-Haq et al, 2016;NİZAM & SELÇUK, 2021) Sexual health * Please note that studies include animals and humans…”

Untitled

“…In addition to Shilajit benefits for diabetes (Gupta et al, 2016;Raju & Sharma, 2016), it can also be beneficial for other diseases and conditions, including insulin resistance (Gupta, 1966;Kanikkannan et al, 1995), obesity Pattonder et al, 2011), inflammation (Firozsalari et al;Pingali & Nutalapati, 2022), oxidative stress (Atashbar et al, 2018;Derhami et al, 2022), arthritis (Azizi et al, 2018;Lawley et al, 2013), cancer (Kloskowski et al, 2021;Pant et al, 2012), bone health (Cesur et al, 2019;Labban, 2013), allergy (Ghosal et al, 1989;Sadeghi et al, 2020), mental health (Jaiswal & Bhattacharya, 1992;Khaksari et al, 2013), immune system (Bižanov et al, 2012;Musthafa et al, 2018), increased energy (Bhattacharyya et al, 2009;Stohs et al, 2017), adaptogenic (Agarwal et al, 2007;Bansal & Banerjee, 2016), antiaging and rejuvenating (Ghosal, 1990;Wilson et al, 2011), and for sexual health (Ikram-ul-Haq et al, 2016;NİZAM & SELÇUK, 2021). These benefits are shown in table 2.…”

“…Research Reference/(s) Diseases/conditions (Gupta et al, 2016;Raju & Sharma, 2016) Diabetes (Ghezelbash et al, 2022;Kanikkannan et al, 1995) Insulin resistance (Patil et al, 2022;Pattonder et al, 2011) Obesity (Firozsalari et al;Pingali & Nutalapati, 2022) Inflammation (Atashbar et al, 2018;Derhami et al, 2022) Oxidative stress (Azizi et al, 2018;Lawley et al, 2013) Arthritis (Kloskowski et al, 2021;Pant et al, 2012) Cancer (Cesur et al, 2019;Labban, 2013) Bone health (Ghosal et al, 1989) Allergy (Jaiswal & Bhattacharya, 1992) Mental health (Bižanov et al, 2012;Musthafa et al, 2018) Immune system (Bhattacharyya et al, 2009;Stohs et al, 2017) Increase Energy (Agarwal et al, 2007;Bansal & Banerjee, 2016) Adaptogenic (adapt to stress) (Ghosal, 1990;Wilson et al, 2011) Anti-aging and rejuvenator (Ikram-ul-Haq et al, 2016;NİZAM & SELÇUK, 2021) Sexual health * Please note that studies include animals and humans…”

Chemical Characteristics and Biotechnological Potentials of Mumio

“…In recent years, Mumio has gained increasing attention from the scientific community for its potential therapeutic benefits (Sweah et al 2023;Gheorghe et al 2022;Öztürk et al 2022;Zandraa et al 2021;Geçgelen cesur et al, 2019). A growing body of research has investigated the various bioactive components of Mumio, including fulvic acid, humic acid, and various minerals, and their potential health benefits (Suraj et al 2007).…”