Does Small Size Vertebral or Vertebrobasilar Artery Matter in Ischemic Stroke?

Park, Jong-Ho

doi:10.5772/27006

Cited by 3 publications

(2 citation statements)

References 41 publications

(58 reference statements)

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“…Rabbits and guinea pigs are often used as an experimental model for the study of spinal cord injury. The cervical spinal cord served as experimental model for the study of several types of damage [13,29,30].…”

Section: Cervical Spinal Cordmentioning

confidence: 99%

Importance of the Arterial Blood Supply to the Rabbit and Guinea Pig Spinal Cord in Experimental Ischemia

Mazensky¹,

Flešárová²

2016

Ischemic Stroke - Updates

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Spinal cord ischemia belongs to the one of the most frequently occurring results of spinal cord damage, with broad range of several symptoms and complications. The superficial position of fine arterial system of the spinal cord predicts the spinal cord ischemic injury. The laboratory animals, such as rabbits and guinea pigs, serve for the study of spinal cord ischemic injury. The aim of this work was to describe the arterial blood supply to the spinal cord in New Zealand White rabbits and English self guinea pigs, using the corrosion and dissecting technique. In both species, we found variations in arrangement and origin of segmental arteries of descending aorta, the basilar artery, the ventral spinal artery, the dorsal spinal arteries, the artery of Adamkiewicz, and the segmental dorsal and ventral branches arising from the arterial spinal branches. The presence of the artery of Adamkiewicz and nearly regular segmental blood supply to the spinal cord are responsible for the use of rabbit and guinea pig as a simple model of ischemic damage to the spinal cord. The understanding of the arterial arrangement to the spinal cord plays a very important role in avoiding the spinal cord ischemia or infarction during surgical interventions to the spine.

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Section: Cervical Spinal Cordmentioning

confidence: 99%

Importance of the Arterial Blood Supply to the Rabbit and Guinea Pig Spinal Cord in Experimental Ischemia

Mazensky¹,

Flešárová²

2016

Ischemic Stroke - Updates

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“…Its incidence has been described in 2-6% of cases in general population. Some authors report the percentage between 10 and 15% (8,9,10).…”

Section: Introductionmentioning

confidence: 99%

The Frequency and Significance of the Vertebral Artery Hypoplasia in Posterior Circulation Stroke

Zafirovska¹,

Saric²,

Petar³

et al. 2016

West Indian Med J

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Objective: Vertebral artery hypoplasia (VAH) is an uncommon embryonic variation of posterior (vertebrobasilar) circulation. The literature reports on its incidence in general population are in the range between 2 and 10%. The aim of the paper was to analyze the frequency and association between VAH and posterior circulation stroke (PCS). Besides VAH, other risk factors responsible for PCS were examined. Methods: The study was a prospective one, conducted at the Neurology Clinic, Clinical Center Niš. It enrolled 50 patients with the established diagnosis of PCS. The control group consisted of 40 patients without PCS. The presence of VAH was determined by performing Color-Doppler Echosonography (CDE) and proved by computed tomography angiography (CTA). Results: Our results showed statistically significant presence of VAH in patients with PCS in comparison to the controls (38%: 10%).VAH was found to be an independent risk factor for PCS onset. The presence of VAH in the group of patients with posterior circulation stroke in relation to other patients from the experimental group without VAH is a poor prognostic parameter concerning the severity of clinical manifestation and the outcome of the disease. Conclusion: VAH is a risk factor for posterior circulation stroke onset. Its presence in patients with posterior circulation stroke is a poor prognostic parameter significantly correlating with the severity of clinical presentation and higher mortality rate.

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Arterial arrangement of the cervical spinal cord in rabbit

et al. 2012

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The aim of this study was to describe the arterial arrangement of the cervical spinal cord in rabbit because it has been used widely to examine the pathophysiology of spinal cord injury. The study was carried out on 20 adult New Zealand White rabbits. We prepared corrosion casts of the arterial system of the cervical spinal cord. Batson's corrosion casting kit no. 17 was used as a casting medium. The origin of the ventral spinal artery from the right vertebral artery was found on average in 40 % of cases. The origin from the left vertebral artery was found on average in 35 % of cases. The ventral spinal artery raised from the anastomosis of two ventral spinal arteries on average in 25 % of cases. The presence of spinal arteries entering the ventral spinal artery in the cervical region was observed in 46.2 % of cases on the right side and in 53.8 % of cases on the left side. On the dorsal surface we found two irregular dorsal spinal arteries receiving dorsal branches of spinal arteries or they were absent. Until the cervical spinal cord arterial arrangement in species of laboratory animals is described in detail, it will be very difficult to determine the appropriate species for experiments in this field. Variations in arterial arrangement can produce biased or erroneous results in studies.

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Does Small Size Vertebral or Vertebrobasilar Artery Matter in Ischemic Stroke?

Cited by 3 publications

References 41 publications

Importance of the Arterial Blood Supply to the Rabbit and Guinea Pig Spinal Cord in Experimental Ischemia

Importance of the Arterial Blood Supply to the Rabbit and Guinea Pig Spinal Cord in Experimental Ischemia

The Frequency and Significance of the Vertebral Artery Hypoplasia in Posterior Circulation Stroke

Arterial arrangement of the cervical spinal cord in rabbit

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