Does suckling offer protection to the lamb against Teladorsagia circumcincta infection?

Iposu, S.O.; McAnulty, Robin W.; Greer, Andrew W.; Xie, Hongliao; Green, R.S.; Stankiewicz, M.; Ar, Sykes

doi:10.1016/j.vetpar.2008.01.034

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…However, the relatively large parameter estimate suggests that the result is of biological significance. A potential explanation for this result is that twins receive less nourishment from their mother, since prolonged suckling provides enhanced parasite resistance in lambs, possibly due to a positive effect on weight gain (Iposu et al 2008). However, by conditioning on LEG and body condition, we can be confident that the higher FEC in twins is not simply due to their being smaller or in worse condition (although this may also be relevant), but to some additional factor.…”

Section: Discussionmentioning

confidence: 99%

Maternal effects and early-life performance are associated with parasite resistance across life in free-living Soay sheep

et al. 2010

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Maternal effects occur when the maternal phenotype influences that of the offspring in addition to the effects of maternal genes, and may have a considerable influence on offspring parasite resistance. These effects, and the effects of early levels of reproduction and parasite resistance, may persist into later life and even influence ageing rates. Here we analyse a 20-year longitudinal data set collected on a free-living population of Soay sheep, to investigate the associations between a suite of maternal phenotypic traits and early-life performance on measures of parasite resistance across life. Our results show that maternal effects are important in determining offspring parasite resistance, since lambs born as twins and those born to the youngest and oldest mothers show higher parasite burdens. We show that the association between parasite resistance and natal litter size persists into adulthood. We also show that age-specific changes in parasite resistance in males are associated with natal litter size, and that age-specific changes in females are influenced by early-life levels of reproduction and parasite infection. These results add to the growing evidence that conditions experienced by individuals during development can have a profound influence on immediate and late-life performance and may even influence ageing.

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Section: Discussionmentioning

confidence: 99%

Maternal effects and early-life performance are associated with parasite resistance across life in free-living Soay sheep

et al. 2010

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“…Overall, it appears the lesser magnitude of both humoral and cell‐mediated responses in lambs to a wide range of GIN antigens compared with their mature counterparts reflects a deficiency in immunological machinery in the very young lamb to respond to antigenic stimulus . In part, this may help explain the lack of impact on lamb performance of T. circumcincta challenge in lambs between 6 weeks of age and 12 weeks of age observed in field studies as the young lamb obviously lack the immunological ability to enter the acquisition phase of immune development and its associated costs. This is in general agreement with the suggested hypothesis of a fitness advantage being conferred to lambs with a delayed mast cell response that results in a disturbance to abomasal integrity although a functional explanation for the immunological hyporesponsiveness in very young lambs to intestinal nematodes is still missing.…”

Section: Factors Influencing the Development Of Immunitymentioning

confidence: 99%

Relative maturity and the development of immunity to gastrointestinal nematodes in sheep: an overlooked paradigm?

Greer

Hamie

2016

Parasite Immunology

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Sheep display considerable variation in both the timing and magnitude of development of immunity to gastrointestinal nematodes (GIN). Onset of immunity is dependent on a number of factors, including antigenic stimulus, nutrition supply, age and size of the animals, the latter of which are confounded. Here, we review the factors associated with the development of immunity to GIN in sheep, particularly in the context of the role that relative maturity may have through applying the rules of genetic size scaling based on examples from published literature. Comparing animals based on their metabolic age, rather than chronological age, may provide an explanation for the timing of immune development and may reduce the variation in immune development that frequently is observed both between and within breeds. Further, this approach may help explain the phenotypic differences in animal performance between animals of varying immunological capacity to GIN through influences on mature body weight. As such, when considering factors influencing immune development to GIN, physiological age or relative maturity may be considered an overlooked paradigm. We propose it may be worthwhile to consider metabolic age when comparing the immune competence of animals to ensure the subjects are at an analogous stage of physiological development.

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“…circumcincta infection compared to their twin weaned counterparts (Iposu et al, 2008). This suggests that improved nutrition is an effective strategy to reduce the debilitating effects of parasite infection.…”

Section: Improved Nutritionmentioning

confidence: 99%

Expression of sheep interleukin 23 (IL23A, alpha subunit p19) in two distinct gastrointestinal diseases

Gossner

Venturina

Peers

et al. 2012

Veterinary Immunology and Immunopathology

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This paper reports the sequence of sheep interleukin 23A (p19), and shows that it shares 98% identity with bovine IL23A, 85% with human and 76% with mouse IL23A. It also reports the existence of two allelic variants that differ largely within the region encoding the amino terminal polypeptide signal sequence. An optimized RT-qPCR assay was used to quantify IL23A transcripts in sheep infected with two common gastrointestinal pathogens, the intracellular bacterium Mycobacterium avium subspecies paratuberculosis and the parasitic nematode Teladorsagia circumcincta. No differential expression of IL23A was detected in the mesenteric lymph node of sheep with the different pathogenic forms of paratuberculosis, however significantly high levels of IL23A were detected in the ileal mucosa of the paucibacillary form in comparison with the asymptomatic or multibacillary forms. Similarly, significantly high levels were present in the gastric lymph node draining Teladorsagia circumcincta-infected abomasum in susceptible sheep. High levels of IL23A seem to be associated with lymphocytic infiltration and inflammation in both diseases but not with the macrophage infiltrate of multibacillary paratuberculosis.

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Does suckling offer protection to the lamb against Teladorsagia circumcincta infection?

Cited by 11 publications

References 38 publications

Maternal effects and early-life performance are associated with parasite resistance across life in free-living Soay sheep

Maternal effects and early-life performance are associated with parasite resistance across life in free-living Soay sheep

Relative maturity and the development of immunity to gastrointestinal nematodes in sheep: an overlooked paradigm?

Expression of sheep interleukin 23 (IL23A, alpha subunit p19) in two distinct gastrointestinal diseases

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