Does the Administration of Diethylstilbestrol during Pregnancy have Therapeutic Value?*†

Dieckmann, Wm.J.; Davis, M. Edward; Rynkiewicz, Lois M.; Pottinger, R.E.

doi:10.1016/s0002-9378(16)38617-3

Cited by 305 publications

(83 citation statements)

References 10 publications

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“…Over the years, studies were conducted regarding the efficacy of DES such as one published in 1953 (5). This randomized double-blind study at the University of Chicago Lying-in-Hospital included 1646 patients and showed no improvement in pregnancy outcome.…”

Section: Indications For the Use Of Desmentioning

confidence: 99%

Antenatal Exposure to DES: Lessons Learned … Future Concerns

Rubin

2007

Obstetrical &Amp; Gynecological Survey

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The short- and long-term effects of the widespread use of diethylstilbestrol (DES) over 3 decades have become a distant memory for many clinicians. Others are too young to remember the flurry of activity in the early 1970s on the part of many medical centers to identify the offspring of women who were prescribed DES during their pregnancies. This medication was given in an attempt to prevent multiple pregnancy-related problems such as miscarriage, premature birth, and abnormal bleeding. The recognition of the association of DES with an increased incidence of cervical and vaginal cancers in very young women led the Food and Drug Administration to ban its use during pregnancy in 1971. Other pregnancy-related problems for the daughters and genitourinary tract changes in the sons did not become apparent until years later. Ongoing follow-up of these offspring has raised concerns for their future as well as their mothers' future. Clinicians need to be up-to-date with current knowledge regarding risks for cancer and other health-related issues.

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Section: Indications For the Use Of Desmentioning

confidence: 99%

Antenatal Exposure to DES: Lessons Learned … Future Concerns

Rubin

2007

Obstetrical &Amp; Gynecological Survey

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“…Estimates vary, but DES was widely prescribed to several million pregnant women with most use occurring between the late 1930s until 1971 in the mistaken belief that it was useful in the treatment of threatened or habitual abortion [14][15][16]. The use of DES during pregnancy was proscribed by the Food and Drug Administration (FDA) in 1971 with the discovery that a small number of women exposed in utero later developed vaginal clear cell adenocarcinoma [16,17].…”

Section: Effects Of Des In Humansmentioning

confidence: 99%

The possible effects of environmental estrogen disrupters on reproductive health

2000

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The term environmental estrogen refers to chemical substances that exhibit some degree of estrogen-like activity. The primary emphasis for potential adverse effects resulting from exposure to environmental estrogens is on in utero exposure because such exposures can occur during critical periods of organogenesis. Assessment of biological plausibility can be based, in part, on the extensive data on the effects of diethylstilbestrol (DES). The available evidence is too limited to judge with any confidence whether sperm counts have declined during the past 50 years. Based on both animal and human data with DES, it is biologically plausible that in utero exposures to exogenous estrogenic compounds are capable of reducing sperm production in adult men. However, the apparent existence of a maternal dose threshold for DES-induced effects on sperm count undermines the likelihood that environmental estrogens, which are substantially less potent, are capable of causing similar effects.

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“…Or, dès 1953, Dieckmann et al [1] mettent en doute l'efficacité de ce produit en publiant une série comparée de 840 patientes traitées par le DES et de 800 cas témoins sans retrouver de différence significative dans les résultats. De plus, en 1970, Herbst et Scully [2] rapportent sept cas d'adénocarcino-mes cervicovaginaux à cellules claires chez des jeunes filles issues de mères ayant absorbé du DES.…”

Section: Introductionunclassified

Utérus DES. Polémiques sur l'hystéroplastie d'agrandissement. Arguments pour

Aubriot¹,

Chapron

2007

Gynécologie Obstétrique & Fertilité

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Does the Administration of Diethylstilbestrol during Pregnancy have Therapeutic Value?*†

Cited by 305 publications

References 10 publications

Antenatal Exposure to DES: Lessons Learned … Future Concerns

Antenatal Exposure to DES: Lessons Learned … Future Concerns

The possible effects of environmental estrogen disrupters on reproductive health

Utérus DES. Polémiques sur l'hystéroplastie d'agrandissement. Arguments pour

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