Does the antimicrobial peptide, granulysin, play a role in decreasing the incidence of secondary bacterial infection in psoriasis?

Mahgoub, Doaa M.; Nagui, Noha; Rashed, Leila A.

doi:10.1097/01.ewx.0000392823.59573.fc

Cited by 2 publications

(5 citation statements)

References 28 publications

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“…There was a signi cant positive correlation between lesional GNLY level and PASI score (p = 0.002). This was in agreement with Mahgoub et al 7 and Elgarhy et al 6 studies.…”

Section: Discussionsupporting

confidence: 93%

“…Regarding tissue GNLY our study revealed that the level of tissue GNLY of lesional and perilesional skin in psoriatic patients, was signi cantly higher when compared to the control group (p value 0.017 and 0.011, respectively). This was consistent with a study done by Mahgoub et al 7 which measured GNLY by ELISA technique and showed a signi cant elevation of its level in lesional psoriatic tissue when compared to the control group (P = 0.001), also consistent with Elgarhy et al 6 and Vičić et al 12 studies which detected a highly signi cant difference in GNLY expression in lesional tissue in psoriasis patients when compared to the control group.…”

Section: Discussionsupporting

confidence: 91%

“…Our study detected a signi cant negative correlation between lesional tissue GNLY and disease duration (p = 0.048). However, Mahgoub et al 7 didn't nd a statistically signi cant correlation between the granulysin levels in the skin biopsies of the patients and disease duration (P = 0.330).…”

Section: Discussionmentioning

confidence: 89%

“…6 Granulysin (GNLY) is a cytolytic and proin ammatory peptide that belongs to a saposin-like family, lipid binding AMPs, and is localized in the granular compartments of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells . 7 GNLY is well associated with different activities of NK cells and CTL in physiological and pathological settings and could be a useful serum marker for monitoring host cell mediated immune cytotoxic responses. GNLY was found at minimal concentrations in the sera of healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

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Serum and Tissue Granulysin as a Possible Key Markers to Detect the Severity of Psoriasis

Gaber

Bakr

ElMelegy

et al. 2022

Preprint

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Background: Psoriasis is a chronic immune-mediated inflammatory skin disease, it is a disorder of both the innate and adaptive immune system. However, new updates are still emerging in its pathogenesis. Psoriasis is characterized by overexpression of antimicrobial peptides. Granulysin (GNLY) is an antimicrobial peptide that may have a role in psoriasis pathogenesis. Objective: To detect the level of serum and tissue (GNLY) in psoriatic patients and correlate it with psoriasis severity. Patients and Methods: The study was performed on 50 individuals, including 2 groups. The first group included 30 psoriasis vulgaris patients and the second group included 20 age and sex matched apparently healthy control individuals. Serum GNLY was determined in all individuals and tissue GNLY was determined in the skin of 8 patients (from lesional and perilesional skin) and 8 controls. Results: serum GNLY was slightly higher in patients group compared to control group with no statistically significant difference while, the level of tissue GNLY of lesional and perilesional skin in psoriatic patients, was significantly higher when compared to control group. Conclusion: In conclusion, granulysin is supposed to play a role in psoriasis pathogenesis and it is positively correlated with psoriasis severity

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“…There was a signi cant positive correlation between lesional GNLY level and PASI score (p = 0.002). This was in agreement with Mahgoub et al 7 and Elgarhy et al 6 studies.…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum and Tissue Granulysin as a Possible Key Markers to Detect the Severity of Psoriasis

Gaber

Bakr

ElMelegy

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…6,7 Granulysin is a cytolytic and proinflammatory peptide that belongs to a family of saposin-like, lipidbinding AMPs, and colocalizes in the granular compartments of human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, along with granzymes and perforin. 8 Granulysin expression has been studied in some inflammatory skin diseases, including lichen planus (LP) and atopic eczema (AE). 9 There have been very few studies published on the expression of granulysin in psoriasis and its possible role in disease kinetics.…”

Section: Introductionmentioning

confidence: 99%