Does the <i>MTHFR</i> A1298C Polymorphism Modulate the Cardiorespiratory Response to Training?

Zarębska, Aleksandra; Jastrzębski, Zbigniew; Sawczyn, Michał; Kozakiewicz-Drobnik, Izabela; Leońska-Duniec, Agata; Kaczmarczyk, Mariusz; Maciejewska-Skrendo, Agnieszka; Żmijewski, Piotr; Trybek, Grzegorz; Smółka, Wojciech; Pilch, Ján; Leźnicka, Katarzyna; Lulińska–Kuklik, Ewelina; Sawczuk, Marek; Massidda, Myosotis

doi:10.1515/hukin-2016-0055

Cited by 15 publications

(12 citation statements)

References 39 publications

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“…Understanding these differences and their underlying causes is crucial for creating research that can span ethnic boundaries. Finally, our results support a previous hypothesis that an association between any genetic variant and athletic performance might depend on the population's ethnic background [8,31,44].…”

Section: Genetic Modelsupporting

confidence: 89%

“…Athletic performance is one of the most complex human phenotypic traits influenced by anthropometric [30], psychological [35] and physiological properties [40], as well as by the training, nutrition and health status of the individual athlete [16]. It is assumed, however, that ath-letic performance variations among athletes are partly due to small contributions of hundreds of genes [8,37]. To date, most of the exercise genomics studies have focused on genotyping predominantly sprint/power or endurance athletes, who represent the physiological end-points of the sporting continuum.…”

Section: Introductionmentioning

confidence: 99%

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Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status.

et al. 2018

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The aim of this study was to investigate the association between the MCT1 (monocarboxylate transporter 1) A1470T polymorphism and positional roles in a large cohort of professional football players from five different countries. We compared genotype distributions of the MCT1 A1470T polymorphism between football players (n=694) and non-athlete controls (n=781) from Italy, Poland, Lithuania, Ukraine and Malta, and we analyzed the MCT1 genotype distributions with respect to the players’ positions in the field (e. g. forwards, midfielders, defenders and goalkeepers). Genomic DNA was extracted from either buccal epithelium or peripheral blood using a standard protocol. In the pooled cohort of Italian, Polish, Lithuanian and Ukrainian football players, forwards (n=148) were more likely than controls (n=781) to possess the A allele (χ2=7.067, p=0.029, FDR q value 0.116), with a greater likelihood of having the AA genotype compared with the TT genotype (OR=1.97; C.I.=1.07-3.64; p=0.021, FDR q value 0.086). The MCT1 AA genotype was significantly more frequent in forwards then in controls. Further studies are needed to confirm these findings in other professional football player cohorts.

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Section: Genetic Modelsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status.

et al. 2018

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“…The problem of regulating the motor activity of a growing person is significant for specialists in the field of physical culture and medicine in Poland, Sweden, Ukraine, Australia and in other countries of the world [13,[35][36][37][38]. The analysis of scientific research on the problems of regulating the motor activity of children allows to study all aspects of the implementation of this activity.…”

Section: Discussionmentioning

confidence: 99%

Modern strategies for regulating the motor activity of preschool and school age children in the educational space

Voloshina

Kondakov

Tretyakov

et al. 2018

PPS

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Purpose:the systematization of modern strategies for regulating the motor activity of preschool and school-age children. The criteria for assessing motor activity taking into account the individual characteristics of children and sociocultural conditions are considered. The adaptive strategy of regulation of the motor activity of a growing person in modern educational space is substantiated. Material:10 theses and more than 80 papers published in specialized journals of Russia, Ukraine, Kazakhstan, Belarus were analyzed. In the article is used quantitative approach, which has research and descriptive character. This approach includes methods for examining documents. The identification of studies over the past 50 years has been carried out. The analysis of normative program-methodological materials, educational standards, exemplary educational programs and the results of their own research was carried out. These studies substantiated various approaches to regulating and forming positive dynamics of motor activity in preschool and school-age children. Results:Three strategies for regulating motor activity were identified: biological, value-social and biosocial (adaptive). Their compliance with the level of scientific and methodological knowledge and domestic experience is established. The limiting factors have been established and ways of transforming the system of physical education at different levels of education have been concretized. The modern adaptive strategy of regulation of the motor activity of preschool children and younger schoolchildren is substantiated. The expediency of its introduction into the educational process is shown. This creates a favorable environment for the physical development of children. Conclusions:The adaptive system for regulating motor activity should take into account: the interests and opportunities of children at all levels of the educational system; regional sports traditions; sociocultural and climatic conditions. It is extremely important to recreate the playing space of childhood. This contributes to the formation of an active position in relation to the physical culture of the individual.

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“…As for professional athletic performance, numerous genetic variants have been recently investigated and associated with predisposition and performance in multiple sports: endurance- [33,34,35] and power-related ones [36,37]. However, some genotypes were not confirmed as genetic markers of exercise performance in the Polish population [38], and further studies are needed.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of catechol-O-methyltransferase ( COMT rs4680:G>A ) and μ-opioid receptor ( OPRM1 rs1799971:A >G ) in relation to pain perception in combat athletes

Leźnicka¹,

Kurzawski²,

Cięszczyk³

et al. 2017

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ABSTRACT:In athletes, pain has diverse functions and a complex etiology. Its role is not limited to indicating the limits of the body, especially in areas that are exposed to maximal forces and stresses and consequently vulnerable to damage or injury. Several common single nucleotide polymorphisms (SNPs) have been recently associated with inter-individual differences in pain perception. Among several other markers, catechol-O-methyltransferase (COMT rs4680:G>A) and the µ-opioid receptor (OPRM1 rs1799971:A >G) were proposed as key factors for pain perception. The aim of the current study was to investigate the potential association between COMT and OPRM1 genotypes and pain perception as well as the relation with elite athlete status. The study involved 395 healthy men, aged 18 to 28 years; 214 combat sports athletes comprised the experimental group and 181 non-athletes comprised the control group. DNA was extracted from buccal cells donated by the subjects, and genotyping for COMT rs4680 and OPRM1 rs1799971 was carried out using realtime PCR. Measurement of the pain threshold and pain tolerance was performed using an algometer and the cold pressor test. The genotype distribution of COMT and OPRM1 polymorphisms did not differ between combat athletes and the control group (p=0.500 and p=0.390). Pain threshold and pain tolerance as both quantitative and qualitative measures did not differ with respect to OPRM1 and COMT polymorphism in either the combat or the control group for any of the analysed genetic models. CITATION:

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Does the MTHFR A1298C Polymorphism Modulate the Cardiorespiratory Response to Training?

Cited by 15 publications

References 39 publications

Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status.

Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status.

Modern strategies for regulating the motor activity of preschool and school age children in the educational space

Polymorphisms of catechol-O-methyltransferase ( COMT rs4680:G>A ) and μ-opioid receptor ( OPRM1 rs1799971:A >G ) in relation to pain perception in combat athletes

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