Does the KDIGO CKD risk stratification based on GFR and proteinuria predict kidney graft failure?

Bucsa, C.; Ștefan, Gabriel; Tacu, D.; Sinescu, I.; Sinescu, Ruxandra Diana; Hârza, M.

doi:10.1007/s11255-014-0761-7

Cited by 13 publications

(14 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2 As such, proteinuria has been included in risk stratification for patients with chronic kidney disease (CKD) in the general population 3 and the utility of this stratification has been assessed in renal transplant recipients. 4 Proteinuria is commonly present after transplantation. Because it is often a marker of allograft damage and is a potentially modifiable risk factor, it is important to recognize early.…”

mentioning

confidence: 99%

Evaluation and Management of Proteinuria After Kidney Transplantation

Tsampalieros

Knoll

2015

Transplantation

View full text Add to dashboard Cite

Proteinuria occurs commonly after kidney transplantation. Because there are no specific guidelines for defining and detecting proteinuria in transplant recipients, its prevalence can vary depending on the methods used. Most often, the same cutoffs for defining proteinuria in the nontransplant population are applied. There are several risk factors for proteinuria, including some transplant-specific diagnoses and immunosuppressive medications. Posttransplantation proteinuria is associated with reduced graft survival as well as an increased risk of cardiovascular events and death. Treatments to decrease proteinuria have been based on blocking the renin-angiotensin-aldosterone system with the use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. This review describes the measurement, prevalence, etiology, prognostic significance, and management of proteinuria in both adult and pediatric transplant recipients.

show abstract

mentioning

confidence: 99%

Evaluation and Management of Proteinuria After Kidney Transplantation

Tsampalieros

Knoll

2015

Transplantation

View full text Add to dashboard Cite

show abstract

“…21,27 These however are very cumbersome and were developed using data from one year post transplant which limit their clinical utility. 21,27 Bucsa et al 28 examined the association between GFR categories, proteinuria, and outcomes in 231 renal transplant recipients but used 24-hour urine total protein collections which were then converted to estimated albumin excretion and the 4 variable MDRD equation. The composite outcome studied was death, ESRD, or a greater than 30% decline in eGFR from 6 months posttransplant.…”

Section: Discussionmentioning

confidence: 99%

Classification of Kidney Transplant Recipients Using a Combination of Estimated GFR and Albuminuria Reflects Risk

White

Akbari

Talreja

et al. 2016

Transplantation Direct

View full text Add to dashboard Cite

BackgroundThe 2012 Kidney Dialysis Initiative Global Outcomes chronic kidney disease (CKD) classification scheme subdivides stage 3 CKD and incorporates the urinary albumin-to-creatinine ratio (ACR). The aim of this study was to evaluate whether the novel scheme provides graded risk in kidney transplant recipients (KTRs).MethodsPrevalent KTRs with available laboratory data were included. The primary outcome was a composite of doubling of serum creatinine, graft failure, or death. Patients were stratified using the CKD-Epidemiolgic Collaboration equation, and ACR and the event rate per 1000 patient-years in each CKD category were calculated.ResultsThere were 269 KTRs with a mean follow-up of 4.5 ± 2.0 years. There was a graded increase in outcomes with increasing ACR and decreasing estimated glomerular filtration rate (eGFR). For the primary outcome, the event rate was 15.3 (95% confidence interval, 4.2-39.2) per 1000 patient-years for those with an eGFR greater than 60 mL/min per 1.73 m2 and an ACR less than 30 mg/g, whereas it was 375 (95% confidence interval, 193.8-655.1) for those with an eGFR less than 30 mL/min per 1.73 m2 and an ACR greater than 300 mg/g.ConclusionsThe novel Kidney Dialysis Initiative Global Outcomes classification scheme provides graded risk for important clinical events in KTRs. This information can be used to identify high-risk patients and to tailor follow-up and management strategies aimed at improving outcomes.

show abstract

“…Хроническая болезнь почек (ХБП) -серьезная проблема для здравоохранения, что нашло отражение в увеличении числа публикаций о ХБП в последние годы, особенно после выхода в свет регламентирующих рекомендаций по ХБП в 2002 и 2012 гг. [1,2]. Проблема ХПБ состоит, прежде всего, в том, что, как многие хронические неинфекционные заболевания, болезнь долгое время протекает бессимптомно, а при позднем выявлении быстро развивается почечная недостаточность c исходом в терминальную стадию и смерть.…”

Section: Gfr and Cardiovascular Risk скф и сердечно-сосудистый рискunclassified

Glomerular Filtration Rate, its Association with Risk Factors and Cardiovascular Diseases. The Results of the ESSE-RF-2 Study

Шальнова¹,

Maksimov²,

Balanova³

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

Aim. To study the influence of social determinants on the frequency of glomerular filtration rate (GFR) categories of various levels, as well as associations with a number of cardiovascular diseases (CVD) and cardiovascular risk factors among the population of four Russian regions included in the ESSE-RF-2.Material and methods. The study was performed as part of a multicenter epidemiological study “Epidemiology of cardiovascular diseases in the regions of the Russian Federation. The second study (ESSE-RF-2)”. In total, 6681 people 25-64 years old from 4 regions of Russian Federation were included in the analysis. The CKD-EPI formula was used to calculate GFR by blood creatinine level. Groups with normal GFR (≥90 ml/min/1.73 m²), with an initial decrease in GFR (<90 ml/min/1.73 m²), and with a decrease in GFR (<60 ml/min/1.73 m²) were distinguished for statistical analysis. Generalized linear/nonlinear analysis (GLM) was used for multivariate assessment and adjustment of results to socio-demographic characteristics.Results. The average GFR level in the total sample was 97.8±16.6 ml/min/1.73 m2 ; 29.0% of individuals had an initial decrease in GFR, 1.6% had a reduced GFR. Age was significantly associated with GFR. A statistically significant association with an initial decrease in GFR was found for: hypercholesterolemia (odds ratio [OR] 1.22; 95% clearance interval [95%CI] 1.14-1.30), hypertriglyceridemia (OR 1.09; 95%CI 1.02-1.17), hyperuricemia (OR 1.51; 95%CI 1.39-1.63), no smoking (OR 0.79; 95%CI 0.73-0.85), history of kidney disease (OR 1.13; 95%CI 1.04-1.22). A more pronounced decrease in GFR was associated with the following factors and diseases: arterial hypertension (OR 1.48; 95%CI 1.07-2.05), low level of high-density lipoproteins (OR 1.36; 95%CI 1.04-1.79), hypertriglyceridemia (OR 1.37; 95%CI 1.08-1.76), hyperuricemia (OR 2.49; 95%CI 1.97-3.16), hyperglycemia (OR 1.35; 95%CI 1.01-1.80), a history of myocardial infarction (OR 1.63; 95%CI 1.13-2.36) and kidney disease (OR 1.50; 95%CI 1.16-1.93).Conclusion. The results of the study indicate a greater number of factors and diseases associated with low GFR compared with the initial decrease, which emphasizes the need for early detection of signs of chronic kidney disease, especially in the elderly, in people with metabolic syndrome, hypertension or diabetes mellitus, as well as a history of kidney disease.

show abstract

Does the KDIGO CKD risk stratification based on GFR and proteinuria predict kidney graft failure?

Abstract: Risk group stratification according to KDIGO guideline on CKD may prove useful in predicting graft outcome, but this should be confirmed in larger cohorts.

Cited by 13 publications

References 39 publications

Evaluation and Management of Proteinuria After Kidney Transplantation

Evaluation and Management of Proteinuria After Kidney Transplantation

Classification of Kidney Transplant Recipients Using a Combination of Estimated GFR and Albuminuria Reflects Risk

Glomerular Filtration Rate, its Association with Risk Factors and Cardiovascular Diseases. The Results of the ESSE-RF-2 Study

Contact Info

Product

Resources

About