2007
DOI: 10.1016/j.jtcvs.2007.05.030
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Does the method of lung preservation influence outcome after transplantation? An analysis of 681 consecutive procedures

Abstract: The methods of lung preservation in current use do not seem to affect early or midterm survival after transplantation, but increasing ischemic time might predispose to increased rejection.

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Cited by 18 publications
(8 citation statements)
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“…10 There was no significant survival benefit with either preservation method, though there was a trend toward improved 3-year survival in LPD stored lungs. This study lacked the breakdown of ischemic time by preservation solution; however this issue was subsequently addressed in a response to the editor.…”
Section: Discussionmentioning
confidence: 87%
See 1 more Smart Citation
“…10 There was no significant survival benefit with either preservation method, though there was a trend toward improved 3-year survival in LPD stored lungs. This study lacked the breakdown of ischemic time by preservation solution; however this issue was subsequently addressed in a response to the editor.…”
Section: Discussionmentioning
confidence: 87%
“…These studies demonstrate LPD lungs have improved early graft function without a survival benefit, but are limited by low sample size. 1013 …”
Section: Introductionmentioning
confidence: 99%
“…A recent UK Cardiothoracic Transplant audit was conducted that reviewed the results of 681 lung transplants between 1995 and 2003. 8 In the review, no significant impact of Papworth solution on survival (at 30 days, 1 year or 3 years) or death due to PGD was found. Although that study contained twice as many patients as our study, it was a nationwide review and therefore would be confounded by many subtle differences and variability between centers, which cannot always be entirely accounted for by stratification or analysis methods.…”
Section: Discussionmentioning
confidence: 87%
“…The review by Ganesh et al is also limited by the PGD data, which include only PGD leading to death. 8 In contrast, we have analyzed data on PGD grade on every patient at multiple time-points. A smaller study of 170 lung transplant patients across two hospitals compared four different preservation solutions and was unable to show any difference in survival between groups.…”
Section: Discussionmentioning
confidence: 99%
“…Der Rückgang an Spenderorganen im europäischen Raum hat zu einer Erweiterung der Spenderkriterien (höheres Alter, län-gere Intubationsdauer, grenzwertige Blutgase, suboptimales Größenmatch) und zu einer Inkaufnahme längerer Transportstrecken geführt, was eine bessere Konservierung zur Kompensierung dieser Nachteile erfordert. Gleichzeitig ist für inadäquate Organkonservierung eine hö-here Frequenz und Intensität von Abstoßungsreaktionen während des postoperativen Verlaufs beschrieben worden [11,12,13]. Eine weitere Verbesserung der bisherigen Konservierungsmethoden ist daher ein wesentliches Anliegen der Lungentransplantation.…”
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