Does the Number or Quality of Pluripotent Bone Marrow Stem Cells Decrease with Age?

Garvin, Kevin L.; Feschuk, Connie A; Sharp, John; Berger, Ann M.

doi:10.1097/blo.0b013e318159a9b8

Cited by 45 publications

(26 citation statements)

References 20 publications

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“…However, no such associations were found in subjects with a low hemoglobin level. Bone marrow activity decreases as individuals age [ 25 ], which may be associated with the increased frequency of anemia seen in the elderly [ 14 ], and bone metabolism is known to be associated with vascular maintenance [ 13 ]. In addition, hypertension is a strong endothelial impairment factor and hemoglobin has been revealed to be positively associated with hypertension [ 15 ], atherosclerosis [ 16 ], and hypertension-induced vascular damage [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Short stature entails a higher risk of endothelial impairment [ 2 ] such as chronic inflammation [ 5 , 6 ], which stimulates endothelial repair activity. Since endothelial activity is closely associated with bone marrow activity [ 13 , 23 ], which is also strongly influenced by age-related decline [ 14 , 25 ], an analysis limited to subjects with high bone marrow activity (high hemoglobin) should strengthen the influence of endothelial repair. However, although both platelet and CD34-positive cell production are stimulated by endothelial injury, aggressive endothelial repair (the cause of atherosclerosis) may cause consumptive reduction of CD34-positive cells, but not platelets [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

et al. 2017

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Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a cross-sectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

et al. 2017

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“…This may or may not be relevant for clinical purposes where after the age of 60 years one can no longer act as a stem cell donor. This decision is primarily justified by the relative inability to harvest an adequate number of HSPC from older adults, as HSPC quality does not appear to be affected by aging [13].…”

Section: Discussionmentioning

confidence: 99%

Hematopoietic Stem and Progenitor Cell (HSPC) Mobilization Responses to Different Exercise Intensities in Young and Older Adults

Nederveen

Baker

Ibrahim

et al. 2020

J. of SCI. IN SPORT AND EXERCISE

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Introduction Hematopoietic stem and progenitor cells (HSPC) are responsible for the reconstitution of blood cells and thought to contribute to peripheral tissue repair. Following acute exercise in young adults, HSPC are mobilized from their niche in bone marrow into circulation, however the kinetics of mobilization following exercise is not well understood in older adults. In the present study, we aimed to investigate how exercise intensity influences mobilization of specific subpopulations of HSPC, and how mobilization is affected by aging. Methods Healthy older men (OM; 69.9 ± 2.0 years) and young men (YM; 21.5 ± 0.8 years) performed three separate bouts of exercise on a cycle ergometer: 70% of their peak work rate (WR peak) until volitional fatigue, 30% of their WR peak work matched to the 70% WR peak trial, and a high intensity interval training (HIIT) trial. Blood samples were collected before, immediately post, and 10, 30, and 60 min post-exercise. Total blood cells, hematocrit, and mononuclear cells isolated by density gradient centrifugation were quantified using flow cytometry. Results Mononuclear cells, CD34 + , CD34 + /CD38 + , CD34 + /CD110 + , CD3 + /CD(16 + 56) + , CD11c + /CD123 − , and CD11c − / CD123 + cells per millilitre of blood increased immediately post-exercise, but predominately in the 70% WR peak trial in both OM and YM. Conclusion Taken together, our evidence suggests that higher intensity exercise but also volume is necessary for the mobilization of HSPC. Furthermore, the pattern of mobilization was nearly identical in OM as compared to YM though to a lesser extent than their younger counterparts.

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“…However, in our subsequent analysis ( n = 191), we could not find any association between serum ALP and arterial stiffness evaluated by cardio-ankle vascular index (CAVI) ( r = −0.02; P = 0.874). Since our study population consists of elderly subjects and side population hematopoietic bone marrow stem cells diminish as individuals age [ 26 , 27 ], so that even vascular injury can activate bone marrow metabolism, the bone marrow could not be activated as it would be in younger participants while the atherosclerotic lesion might have originated in their younger years. Furthermore, extensive reduction in bone marrow activity also may have a confounding effect on the aforementioned associations.…”

Section: Discussionmentioning

confidence: 99%

Association between circulating CD34-positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men

Shimizu

Sato

Koyamatsu

et al. 2016

J Physiol Anthropol

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BackgroundRecent studies have confirmed an association between bone metabolism and vascular homeostasis. However, no study has examined the relationship between serum alkaline phosphatase (ALP) (a marker of bone metabolism) and circulating immature cell such as CD34-positive cells (a marker of vascular homeostasis).MethodsWe conducted a cross-sectional study of this association in 272 elderly Japanese men (60–79 years). Because low body mass index (BMI) status is a known characteristic of Japanese with a high incidence rate of stroke, we used a stratified analysis based on BMI.ResultsMultivariable linear regression analysis adjusted for confounding factors showed a significant correlation between serum ALP and the number of circulating CD34-positive cells, especially for participants with low BMI (<23 kg/m2). The parameter estimates (β) and 95 % confidence intervals (CI) for one standard deviation increments in serum ALP levels (62 IU/L) for the circulating CD34-positive cell count were β = 0.25 (0.04, 0.45) for total subjects, β = 0.45 (0.16, 0.75) for participants with low BMI (<23 kg/m2), and β = 0.04 (−0.25, 0.34) for participants with high BMI (≥23 kg/m2).ConclusionSerum ALP correlates positively with circulating CD34-positive cells among a general population of elderly Japanese men, especially those with low BMI (<23 kg/m2). These findings suggest that serum ALP levels may constitute an efficient tool for estimating the risk of insufficient vascular homeostasis, especially for participants with relatively few classical cardiovascular risk factors.

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Does the Number or Quality of Pluripotent Bone Marrow Stem Cells Decrease with Age?

Cited by 45 publications

References 20 publications

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

Hematopoietic Stem and Progenitor Cell (HSPC) Mobilization Responses to Different Exercise Intensities in Young and Older Adults

Association between circulating CD34-positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men

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