Does the Periodontal Health of Thalassemia Major Patients Have an Impact on the Blood Lipid Profiles?

Ay, Zühal Yetkin; Oruçoğlu, Aslıhan; Kılınç, Gizem; Öztürk, Mine; Kilbas, Aynur; Uşkun, Ersin; Bozkurt, Fatma Yeşim; Canatan, Duran

doi:10.1097/mph.0b013e31814d68c3

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…Conflicting results have been found regarding the association between thalassemia and periodontal disease. While no difference in plaque index, gingival index, or periodontal probing depth was found between thalassemia patients and healthy controls [30], other studies reported a worse periodontal condition in thalassemia [29,48,49]. These discrepant results might be explained by the age difference of the included participants between the studies.…”

Section: Anemia and Oral Healthmentioning

confidence: 81%

“…They showed that among SCD patients with a sickle cell crisis, having a dental infection was associated with a 72% increased likelihood of being admitted to a hospital. A preliminary report in thalassemia showed that triglycerides and cholesterol/high-density lipoprotein ratio correlated positively with the periodontal parameters, suggesting that periodontal health might affect the lipid profile of thalassemia patients [49].…”

Section: Anemia and Oral Healthmentioning

confidence: 97%

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Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

Boström

Lira-Júnior

2019

Curr Oral Health Rep

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Purpose of Review This review aims to summarize the literature on inherited hemoglobin and coagulation disorders, focusing on sickle cell disease (SCD), thalassemia, hemophilia, and von Willebrand disease (vWD), and their impact on oral health. Clinical dental management of patients with these conditions is also reviewed. Recent Findings There is no evident association between caries and SCD. Despite limited available studies, there may be a possible association between caries and thalassemia, which could relate to salivary changes in immunoglobulin A and Streptococcus mutans reported in these patients. Controversial results on the caries experience of hemophilia and vWD patients are found in the literature, which are likely to reflect differences in the provided preventive dental care of these patients rather than a biological association. Current evidence does not support any association between periodontal disease and SCD. The literature on periodontal disease and thalassemia shows controversial results although some evidence suggests differences in the gingival inflammation of thalassemia patients with increased levels of inflammatory cytokines and matrix metalloproteinases, deserving further investigation. The available literature does not provide evidence of an increased risk for gingival bleeding or periodontal disease in patients with hemophilia or vWD. Dental management of these patients requires appropriate measures to prevent infection and excessive bleeding. The use of local hemostatic may often be sufficient; however, in severe bleeding disorders, systemic hemostatic or replacement therapy may be required, and procedures are recommended to be planned with the patient's hematologist. Summary Maintaining good oral health through preventive dentistry is important for patients with inherited hemoglobin and coagulation disorders as that may prevent the risk of infection and the need for invasive dental treatments that can result in bleeding complications. Keywords Hematologic diseases. Anemia. Blood coagulation disorders. Oral health. Periodontal diseases. Dental caries This article is part of the Topical Collection on Systemic Diseases * Elisabeth A.

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Section: Anemia and Oral Healthmentioning

confidence: 81%

Section: Anemia and Oral Healthmentioning

confidence: 97%

Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

Boström

Lira-Júnior

2019

Curr Oral Health Rep

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“…In 2007, Ay et al . (20), compared to the blood lipid levels and periodontal parameters (gingival index, plaque index, probing bleeding, probing depth) in 24 TM patients with 20 age-matched control patients, and found that all periodontal parameters were significantly higher in the TM patients. Siamopoulou-Mavridou et al .…”

Section: Discussionmentioning

confidence: 99%

Evaluation the oral hygiene conditions, oral Candida colonization and salivary Streptococcus mutans and Lactobacilli density in a group of β-thalassemic children and adolescence

Karayilmaz

Yalçin-Erman²,

Erken-Güngör³

et al. 2019

Med Oral

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Background In this study, the prevalence and distribution of dental caries and oral hygiene conditions in a group of patients with β-TM are evaluated and the results compared to age-and gender-matched healthy patients. In addition, oral candida colonization and the density of Streptococcus mutans (S.mutans) and Lactobacilli in the total saliva are assessed.Material and Methods This study involved 59 β-TM patients between 6-16 years old (mean:11.59±3.22), who applied to the Department of Pedodontics, Faculty of Dentistry, Akdeniz University, with ongoing follow-up, treatment and regular blood transfusions. All enrolled patients were diagnosed with β-TM by the Department of Pediatric Hematology and Oncology, Faculty of Medicine, Akdeniz University. As a control group, age-and gender-matched healthy 50 patients were included to the study.ResultsPlaque (p=0.001), DMFT (p=0.009) and DMFS (p=0.039) indices were significantly higher in the β-TM patients, whereas, the oral hygiene status was significantly lower (p=0.004). Saliva buffering capacity average was insignificantly but slightly more in β-TM patients(p=0.131). While S.mutans values were significantly higher in the β-TM patients (p=0.002), no significant difference was found in the Lactobacillus (p=0.131) and Candida values (p=0.33). Conclusions: DMFT, DMFS, Plaque and oral hygiene indices and S.mutans values were found significantly different in β-TM patients than healthy, control group patients, in this study. Key words:Thalassemia major, DMFT, S.mutans, Lactobacilli, Candida.

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