Does the presence of ANCA in patients with ulcerative colitis necessarily imply renal involvement?

Rosa, Monica; Esposito, Ciro; Caglioti, Alfredo; Mazza, Giuseppe; Capria, Maria; Comi, Nicolino; Monteleone, Giovanni; Sinico, Renato Alberto; Fuiano, Giorgio

doi:10.1093/oxfordjournals.ndt.a027209

Cited by 10 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This case challenges the view that ANCA in UC is not clinically relevant [5,9]. It is important to determine the antigenic specificity of ANCA rather than rely on immunofluorescence analysis.…”

Section: Discussionmentioning

confidence: 97%

“…In one study of 50 patients with UC, 54% were shown to be either p-ANCA or c-ANCA positive but none of these antibodies reacted with PR3 or MPO [4]. In another study, ANCA-positive patients with UC were followed for a year during which no evidence of glomerulonephritis was found [5]. The authors concluded that ANCA found in UC are different to those associated with vasculitis, noting that none of the study patients had ANCA specific for PR3 or MPO.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Systemic Vasculitis and p-ANCA Positivity Developing in a Patient with Ulcerative Colitis and the Antiphospholipid Syndrome

Satchell

Anthony

1999

Nephron

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Systemic Vasculitis and p-ANCA Positivity Developing in a Patient with Ulcerative Colitis and the Antiphospholipid Syndrome

Satchell

Anthony

1999

Nephron

View full text Add to dashboard Cite

“…However, Gionchetti et al [20] reported that ANCAs are unlikely to contribute to the pathogenesis of UC. Rosa et al [21] reported that renal damage was not observed in ANCA-positive patients with UC even after 1 year of follow-up. In the present study, we did not fi nd a relation between ANCA titers and urinary albumin excretion (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Effect of Granulocyte and Monocyte Adsorption Apheresis on Urinary Albumin Excretion and Plasma Endothelin-1 Concentration in Patients with Active Ulcerative Colitis

Nakamura

Kawagoe²,

Matsuda³

et al. 2004

Blood Purif

View full text Add to dashboard Cite

Background/Aim: Increases in microalbuminuria and endothelin (ET-1) are involved in the development of ulcerative colitis (UC) and in its progress. Because granulocyte and monocyte adsorption apheresis has proven to be useful in the treatment of UC, we examined whether urinary albumin excretion and plasma ET-1 concentrations are altered and whether granulocyte and monocyte adsorption apheresis affects the concentrations of these two factors in patients with active UC. Methods: Twenty patients with active UC and 20 age-matched healthy volunteers (our hospital staffs) were included in this study. UC patients were randomly divided into two treatment groups: a granulocyte and monocyte adsorption treatment group (n = 10) and a conventional treatment group (n = 10). The urine albumin/creatinine ratio, plasma ET-1 concentration and tumor necrosis factor (TNF)-α were determined before and after treatment and compared between 2 treatment groups. The 10 adsorption treatment patients underwent 5 consecutive weekly apheresis sessions, each of 60 min duration at a flow rate of 30 ml/min. Results: The urine albumin/creatinine ratio in UC patients (6.4 ± 2.2 mg/mmol) were higher than that in healthy subjects (1.0 ± 0.7 mg/mmol, p < 0.01). In addition, the plasma ET-1 level in UC patients (3.5 ±1.5 pg/ml) was higher than that in healthy subjects (0.8 ± 0.4 pg/ml, p < 0.01). Plasma TNF-α was detected in UC patients (18.8 ± 8.4 pg/ml), but not in healthy subjects. The urine albumin/creatinine ratio was highly correlated with the plasma ET-1 level (r = 0.62; p < 0.01) and plasma TNF-a level (r = 0.66, p < 0.01). Granulocyte and monocyte adsorption apheresis reduced the urine albumin/ creatinine ratio from 6.6 ± 2.4 to 1.8 ± 0.6 mg/mmol (p < 0.01), reduced the plasma ET-1 level from 3.7 ± 1.6 to 1.4 ± 0.6 pg/ml (p < 0.05) and reduced the plasma TNF-α from 19.2 ± 8.6 to 3.8 ± 1.2 pg/ml (p < 0.01). Conventional treatment did not affect these factors. Conclusion: Our data suggest that increases in the urine albumin/creatinine ratio, ET-1 and TNF-α play an important role in active UC and that granulocyte and monocyte adsorption apheresis is effective in ameliorating such increases.

show abstract

“…These antibodies are not usually considered to carry potential for the development of systemic vasculitis as they lack specificity for Proteinase 3 (PR3) or Myeloperoxidase (MPO). ANCA-positive patients with UC were followed for a year during which no evidence of GN was found [14].…”

Section: Gr Up Smmentioning

confidence: 99%

Focal Segmental Glomerulosclerosis Secondary to Mesalamine Use in a Patient with Ulcerative Colitis

Abdallah¹,

Al-Helal²,

Asad³

et al. 2017

SM J Nephrol Therap.

View full text Add to dashboard Cite

Background:The association between Ulcerative Colitis (UC) and Focal Segmental Glomerulosclerosis (FSGS) is an unexpected condition. Herein we reported a case of FSGS secondary to mesalamine use in a Kuwaiti patient with UC. Case presentation:A 32 years-old man, with a 6-month's history of UC, was admitted with proteinuria and elevated serum creatinine after the use of mesalamine. On March, 2016, there was repeated vomiting, fresh bleeding per rectum for which segmoidoscopy and rectal biopsy done on April, 2016 and revealed UC and mesalamine was started. On October, 2016, the patient started to complain from puffiness of eyelids, LL oedema and headache. There was a positive family history of renal failure. Physical examination, there was hypertension, bilateral mild pitting lower limb oedema. Laboratory investigations demonstrated serum creatinine 143 umol/L and proteinuria 1.9 g/24 h. The old values showed serum creatinine level of 76 umol/L and 24h urine protein level of 140mg/day before starting mesalamine. All immunology and virology tests were negative. Kidney ultrasound was normal, so kidney biopsy was performed and revealed FSGS. The patient treated with prednisolone 30 mg/day, valsartan 160 mg/day with discontinuation of mesalamine. Blood pressure was controlled and kidney function tests and proteinuria improved. Conclusion:Mesalamine use in patients with UC can be associated with FSGS, warranting, the necessary of following the kidney function and proteins in urine while the patients with UC on mesalamine treatment.

show abstract

Does the presence of ANCA in patients with ulcerative colitis necessarily imply renal involvement?

Cited by 10 publications

References 30 publications

Systemic Vasculitis and p-ANCA Positivity Developing in a Patient with Ulcerative Colitis and the Antiphospholipid Syndrome

Systemic Vasculitis and p-ANCA Positivity Developing in a Patient with Ulcerative Colitis and the Antiphospholipid Syndrome

Effect of Granulocyte and Monocyte Adsorption Apheresis on Urinary Albumin Excretion and Plasma Endothelin-1 Concentration in Patients with Active Ulcerative Colitis

Focal Segmental Glomerulosclerosis Secondary to Mesalamine Use in a Patient with Ulcerative Colitis

Contact Info

Product

Resources

About