Does Three-Dimensional External Beam Partial Breast Irradiation Spare Lung Tissue Compared With Standard Whole Breast Irradiation?

Jain, Anudh K.; Vallow, Laura A.; Gale, Ashley A.; Buskirk, Steven J.

doi:10.1016/j.ijrobp.2008.10.041

Cited by 17 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However BT was not in focus and the allowed BT techniques were Mammosite or single catheter device. Published works from this trial are mostly concentrated on EBRT issues [ 56 – 58 ].…”

Section: Discussionmentioning

confidence: 99%

Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database

et al. 2016

View full text Add to dashboard Cite

BackgroundTo evaluate the current status of prospective interventional clinical trials that includes brachytherapy (BT) procedures.MethodsThe records of 175,538 (100 %) clinical trials registered at ClinicalTrials.gov were downloaded on September 2014 and a database was established. Trials using BT as an intervention were identified for further analyses. The selected trials were manually categorized according to indication(s), BT source, applied dose rate, primary sponsor type, location, protocol initiator and funding source. We analyzed trials across 8 available trial protocol elements registered within the database.ResultsIn total 245 clinical trials were identified, 147 with BT as primary investigated treatment modality and 98 that included BT as an optional treatment component or as part of the standard treatment. Academic centers were the most frequent protocol initiators in trials where BT was the primary investigational treatment modality (p < 0.01). High dose rate (HDR) BT was the most frequently investigated type of BT dose rate (46.3 %) followed by low dose rate (LDR) (42.0 %). Prostate was the most frequently investigated tumor entity in trials with BT as the primary treatment modality (40.1 %) followed by breast cancer (17.0 %). BT was rarely the primary investigated treatment modality for cervical cancer (6.8 %).ConclusionMost clinical trials using BT are predominantly in early phases, investigator-initiated and with low accrual numbers. Current investigational activities that include BT mainly focus on prostate and breast cancers. Important questions concerning the optimal usage of BT will not be answered in the near future.Electronic supplementary materialThe online version of this article (doi:10.1186/s13014-016-0624-8) contains supplementary material, which is available to authorized users.

show abstract

“…However BT was not in focus and the allowed BT techniques were Mammosite or single catheter device. Published works from this trial are mostly concentrated on EBRT issues [ 56 – 58 ].…”

Section: Discussionmentioning

confidence: 99%

Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Indeed a recent study reported that 3D-conformal PBI increased the volume of lung exposed to low-dose radiation whilst decreasing the volume of tissue exposed to higher-dose radiation (38). We found that supine PBI reduced mean heart-NTD mean (by 0.6Gy), mean LAD-NTD mean (9Gy), mean LAD max (23Gy), mean ipsilateral-lung-NTD mean (3Gy) and mean chest-wall V 50Gy (17cm 3 ) compared to supine WBI.…”

Section: Pbi Versus Wbimentioning

confidence: 99%

Prone versus supine positioning for whole and partial-breast radiotherapy: A comparison of non-target tissue dosimetry

Kirby

Evans

Donovan

et al. 2010

Radiotherapy and Oncology

151

133

View full text Add to dashboard Cite

“…The institutional practice for the original delivered WBI treatment used a tangential planning target volume (PTV) delineated according to the RTOG 0413 WBI protocol without a CTV. 5 The PTV was cropped at the lung-chest wall interface, and the lung depth did not exceed 3 cm. For this study, this volume was named PTV_Tang_Plan.…”

Section: Methodsmentioning

confidence: 99%

“…One of the most widely used delineation guideline is the RTOG 0413 WBI (Tangent) Protocol, which includes all clinically palpable breast tissue in its tangential design. 5 The adoption of CT-based radiotherapy planning and the lack of an anatomical basis in this guideline drove the development of two consensus guidelines: the RTOG (Radiation Therapy Oncology Group) and the European SocieTy of Radiation Therapy (ESTRO) consensus guidelines. 3,4…”

Section: Introductionmentioning

confidence: 99%

Plan quality assessment of modern radiotherapy delivery techniques in left-sided breast cancer: an analysis stratified by target delineation guidelines

Ahmad

Chufal

Bhatt³

et al. 2020

BJR|Open

View full text Add to dashboard Cite

Objective: This study compares planning techniques stratified by consensus delineation guidelines in patients undergoing whole-breast radiotherapy based on an objective plan quality assessment scale. Methods: 10 patients with left-sided breast cancer were randomly selected, and target delineation for intact breast was performed using Tangent (RTOG 0413), ESTRO, and RTOG guidelines. Consensus Plan Quality Metric (PQM) scoring was defined and communicated to the physicist before commencing treatment planning. Field-in-field IMRT (FiF), inverse IMRT (IMRT) and volumetric modulated arc therapy (VMAT) plans were created for each delineation. Statistical analyses utilised a two-way repeated measures analysis of variance, after applying a Bonferroni correction. Results: Total PQM score of plans for Tangent and ESTRO were comparable for FiF and IMRT techniques (FiF vs IMRT for Tangent, p = 0.637; FiF vs IMRT for ESTRO, p = 0.304), and were also significantly higher compared to VMAT. Total PQM score of plans for RTOG revealed that IMRT planning achieved a significantly higher score compared to both FiF and VMAT (IMRT vs FiF, p < 0.001; IMRT vs VMAT, p < 0.001). Conclusions: Total PQM scores were equivalent for FiF and IMRT for both Tangent and ESTRO delineations, whereas IMRT was best suited for RTOG delineation. Advances in knowledge: FiF and IMRT planning techniques are best suited for ESTRO or Tangent delineations. IMRT also yields better results with RTOG delineation.

show abstract

Does Three-Dimensional External Beam Partial Breast Irradiation Spare Lung Tissue Compared With Standard Whole Breast Irradiation?

Cited by 17 publications

References 37 publications

Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database

Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database

Prone versus supine positioning for whole and partial-breast radiotherapy: A comparison of non-target tissue dosimetry

Plan quality assessment of modern radiotherapy delivery techniques in left-sided breast cancer: an analysis stratified by target delineation guidelines

Contact Info

Product

Resources

About