Does transrectal ultrasound guided eight‐core prostate biopsy improve cancer detection rates in patients with prostate‐specific antigen levels of 4.1–10 ng/mL?

Yamamoto, Shinya; Ito, Takaaki; Aizawa, Taku; Noda, Kenjiro; Umezu, Kiyokazu; Ohtsuru, Norihiko; Hata, Kenichi

doi:10.1111/j.1442-2042.2004.00814.x

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…23 The main purpose of this study was to evaluate the efficacy of lateral biopsy on the detection rate of prostate cancer in Japan, where additional biopsies are often carried out with sextant biopsies. 24,25 Our results did not support previous studies showing that lateral biopsies allow a higher detection rate of prostate cancer. Although additional studies with more patients are needed to draw firm conclusions about the value of lateral biopsies, the current data may be useful when determining which biopsy procedure to carry out.…”

Section: Discussioncontrasting

confidence: 99%

“…The main purpose of this study was to evaluate the efficacy of lateral biopsy on the detection rate of prostate cancer in Japan, where additional biopsies are often carried out with sextant biopsies 24,25 . Our results did not support previous studies showing that lateral biopsies allow a higher detection rate of prostate cancer.…”

Section: Discussioncontrasting

confidence: 81%

“…Yamamoto et al . reported sextant plus lateral biopsy (two additional cores taken from each side far lateral of the PZ) did not show significantly higher detection rates than sextant biopsy alone 25 . However, interestingly, 10‐core biopsy (sextant plus an additional four cores from the far lateral areas of the prostate) was shown to be superior to the sextant biopsy; even after including a second set of sextant biopsies, the total detection rate with these 12‐core biopsies was inferior to that of the 10‐core technique 27 .…”

Section: Discussionmentioning

confidence: 80%

“…26 Yamamoto et al reported sextant plus lateral biopsy (two additional cores taken from each side far lateral of the PZ) did not show significantly higher detection rates than sextant biopsy alone. 25 However, interestingly, 10-core biopsy (sextant plus an additional four cores from the far lateral areas of the prostate) was shown to be superior to the sextant biopsy; even after including a second set of sextant biopsies, the total detection rate with these 12-core biopsies was inferior to that of the 10-core technique. 27 Although our statistical data did not show a significantly higher detection rate of prostate cancer using the lateral biopsy technique, there were 11 patients in whom cancer was detected only in the additional samples obtained by the lateral biopsy.…”

Section: Discussionmentioning

confidence: 99%

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Significance of lateral biopsy specimens during transrectal ultrasound‐guided prostate biopsies in Japanese men

et al. 2007

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Objectives: Lateral biopsies are thought to have a better cancer detection rate compared with standard sextant biopsies. This study aimed to determine whether lateral peripheral zone biopsies in Japanese men who underwent transrectal ultrasound-guided prostate biopsies provided a significantly higher cancer detection rate than sextant biopsies. Methods: Between 1999 and 2004, data were collected from 461 men who underwent prostate biopsy and had enough data regarding the performance of lateral biopsies for statistical analysis. There were two categories in this study: (i) patients who underwent sextant prostate biopsies; and (ii) patients who underwent sextant biopsies plus lateral biopsies. Results: Prostate cancer was detected in 141 (30.6%) of 461 patients. It was detected in 24 (22.2%) of 108 patients who underwent sextant biopsies and 117 (33.1%) of 353 patients who underwent sextant plus lateral biopsies. Lateral biopsies were not associated with a statistically higher rate of positive biopsy findings; however, we found a significantly higher ratio of patients with positive findings in those with prostate specific antigen (PSA) levels Յ10 ng/mL (10 of 40, 25%) than in those with PSA levels >10 ng/mL (one of 71, 1.4%) among those who had positive cores only in lateral biopsy samples (P < 0.0001). Conclusions: Lateral biopsies did not show a significantly higher detection ratio of prostate cancer compared to sextant biopsies. However, lateral biopsies were more effective than sextant biopsies in patients with lower PSA levels. Our findings might be useful for the establishment of biopsy strategies to detect prostate cancer, especially in patients with lower PSA levels.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Significance of lateral biopsy specimens during transrectal ultrasound‐guided prostate biopsies in Japanese men

et al. 2007

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“…The cancer detection rate was 18.2% for PSA levels of 2.5-4.0,31 % for PSA of 4.01-10.0, and 50% for PSA of 10.01-20.0 ng/mL. 8 In other work from Japan, two additional cores from the transition zone (TZ) were added to the 12-core transperineal biopsy. In 289 patients with increased PSA and/or positive DRE, prostate cancer detection rate was 36% (105/289).…”

Section: Results Of Transperineal Biopsymentioning

confidence: 99%

Transperineal Prostate Biopsy

Emiliozzi

Pansadoro

2008

Prostate Biopsy

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Transperineal prostate biopsy is recelvlOg renewed scientific interest. Although neglected for several decades in favor of transrectal ultrasound biopsy, the transperineal procedure continues to have a minor, but defined and specific role in prostate cancer diagnosis. It is an effective procedure for detection and has a low incidence of infective complications. This chapter illustrates the technique and surgical approach for transperineal biopsy. Comparison of the two procedures is offered.

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Extensive biopsy using a combined transperineal and transrectal approach to improve prostate cancer detection

et al. 2005

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Purpose : Previous studies have indicated that 6-core transrectal prostate biopsy misses a considerable number of cancers. We performed an extensive biopsy protocol of 12-core sampling using both transperineal and transrectal approaches to determine the impact on the cancer detection rate. Materials and methods : We prospectively evaluated 402 men who underwent 6-core transperineal and 6-core transrectal biopsies simultaneously due to abnormal digital rectal examination (DRE) and/or elevated prostate-specific antigen (PSA) levels of 4.0 ng/ mL or greater. Using the transperineal approach we obtained four cores from the bilateral peripheral zone targeting the lateral and parasagittal areas and two cores from the bilateral transition zone. The following transrectal biopsy was performed traditionally. We compared cancer detection rate between the extended 12-core procedure and conventional 6-core transperineal and transrectal groups in terms of total PSA and DRE findings. Results : Using the extensive combined method, prostate cancer was detected in 195 cases (48.5%) and the detection rate significantly increased 7.2% and 8.5% compared to the transperineal and transrectal groups, respectively. According to PSA levels and DRE findings, the cancer detection rate by the combined method was significantly improved in patients with PSA levels of 4-10 ng/mL and negative DRE: 10.3% and 11.6% compared to the transperineal and transrectal groups, respectively. Conclusions : The extensive 12-core method significantly improved the overall cancer detection rate and was especially efficient for men with PSA levels of 4-10 ng/mL accompanied by a negative DRE finding.

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Does transrectal ultrasound guided eight‐core prostate biopsy improve cancer detection rates in patients with prostate‐specific antigen levels of 4.1–10 ng/mL?

Abstract: Background : To investigate retrospectively whether the eight-core biopsy method improves the prostate cancer detection rate when compared with the standard sextant biopsy method in patients with prostate specific antigen (PSA) levels of 4

Cited by 6 publications

References 24 publications

Significance of lateral biopsy specimens during transrectal ultrasound‐guided prostate biopsies in Japanese men

Significance of lateral biopsy specimens during transrectal ultrasound‐guided prostate biopsies in Japanese men

Transperineal Prostate Biopsy

Extensive biopsy using a combined transperineal and transrectal approach to improve prostate cancer detection

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