Does unsaponifiable fraction of grape seed oil attenuate nitric oxide production, oxidant and cytotoxicity activities

Harbeoui, Hela; Dakhlaoui, Sarra; Wannes, Wissem Aidi; Bourgou, Soumaya; Hammami, Majdi; Khan, Naim Akhtar; Tounsi, Moufida Saïdani

doi:10.1111/jfbc.12940

Cited by 13 publications

(7 citation statements)

References 30 publications

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“…Several studies have shown that grape seed oil delays senescence by attenuating oxidative (Harbeoui et al. 2019 ) and inflammatory responses (Millan-Linares et al. 2018 ).…”

Section: Introductionmentioning

confidence: 99%

SIRT 3 was involved in Lycium barbarum seed oil protection testis from oxidative stress: in vitro and in vivo analyses

Zhou

Wang

Zhao

et al. 2021

Pharmaceutical Biology

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Context Lycium barbarum L. (Solanaceae) seed oil (LBSO) exerts LBSO exerts protective effects in the testis in vivo and in vitro via upregulating SIRT3. Objective This study evaluates the effects and mechanism of LBSO in the d -galactose ( d -gal)-induced ageing testis. Materials and methods Male Sprague Dawley (SD) rats ( n = 30, 8-week-old) were randomly divided into three groups: LBSO group ( n = 10) where rats received subcutaneous injection of d -gal at 125 mg/kg/day for 8 weeks and intragastric administration of LBSO at 1000 mg/kg/day for 4 weeks, ageing model group ( n = 10) received 8-week-sunbcutaneous injection of d -gal, and control group ( n = 10) with same administration of normal saline. Lentivirus had established TM4 cells with SIRT3 overexpression or silencing before LBSO intervened in vitro . Results Treatment with LBSO, the levels of INHB and testosterone both increased, compared to ageing model. In vitro , we found the ED 50 of LBSO was 86.72 ± 1.49 and when the concentration of LBSO at 100 μg/mL to intervene TM4 cells, the number of cells increased from 8120 ± 676.2 to 15251 ± 1119, and the expression of SIRT3, HO-1, and SOD upregulated. However, HO-1 and SOD were dysregulated by silencing SIRT3. On the other hand, the expression of AMPK and PGC-1 α upregulated as an effect of SIRT3 overexpression by lentivirus, meanwhile the same increasing trend of that being found in cells treated with LBSO, compared to control group. Discussion and conclusions LBSO alleviated oxidative stress in d -gal-induced sub-acutely ageing testis and TM4 cells by suppressing the oxidative stress to mitochondria via SIRT3/AMPK/PGC-1α.

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“…Several studies have shown that grape seed oil delays senescence by attenuating oxidative (Harbeoui et al. 2019 ) and inflammatory responses (Millan-Linares et al. 2018 ).…”

Section: Introductionmentioning

confidence: 99%

SIRT 3 was involved in Lycium barbarum seed oil protection testis from oxidative stress: in vitro and in vivo analyses

Zhou

Wang

Zhao

et al. 2021

Pharmaceutical Biology

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“…confirmed cytotoxicity and anti‐inflammatory effects of GSO unsaponifiable fraction (tocopherols, sterols, and triterpenoids). [ 13 ] In addition, GSO has been reported as a material with inhibitory effect on the growth of some pathogens ( Staphylococcus aureus and Escherichia coli) . [ 9 ] However, literature lacks studies conducted in order to examine GSO obtained from different varieties as well as against different microbial strains.…”

Section: Introductionmentioning

confidence: 99%

Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment

Dabetić

Todorović

Djuričić

et al. 2020

Euro J Lipid Sci & Tech

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The amount of organic pomace, left behind agricultural processes, is continuously rising in accordance with industrial progress. Grape pomace, generated in the wine industry all over the world, represents a raw material for obtaining valuable products. Grape seeds are especially rich in oil containing bioactive compounds that can have various health-related effects. The aim of the study is to compare the quality of seed oils obtained from six white grapes, including two Serbian autochthonous varieties. Linoleic acid, associated with numerous health benefits, is the major fatty acid in all samples (≈66% of total); -tocopherol is the main tocopherol homologue. Total polyphenol content ranges from 73.4 to 104.3 mg of gallic acid equivalents per 100 g. In order to provide comprehensive information about antioxidant capacity of grape seed oil (GSO), three tests are performed (ferric ion reducing antioxidant power; 2,2'-diphenyl-1-picrylhydrazyl, and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging). Antimicrobial activity is investigated against different strains; however, GSO inhibits the growth of Staphylococcus aureus and Candida albicans. Obtained results are used to develop a novel approach for oil quality assessment. Calculated oil quality scores (OQS) reveal no significant difference between international and autochthonous varieties, although Smederevka stands out as the most potent one.Practical applications: Considering the progressive waste increase in the wine industry and keeping in mind all health-promoting effects of grape seed oil (GSO), it is clearly observed that oil production represents a profitable and sustainable utilization of grape seeds. The results of the present study show that GSO is a rich source of compounds with antioxidant and antimicrobial properties. In addition, this work provides deeper insight into a quality of Serbian autochthonous grape varieties that are still insufficiently explored. Furthermore, the proposed oil quality score could be used as a comprehensive and unbiased method that enables quality assessment of oils. This tool can find practical application in comparing different plant oils regarding their compositional and functional properties. Finally, it would contribute to making some general oil intake recommendations.

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“…β-sitosterol represents the main sterol in grapeseed oil, and α-tocopherol represents the main tocopherol, reaching values of around 70% of tocopherols, corresponding to 3.8 mg/100 g of oil [ 18 ]. Taking into account the incorporation of GP into the studied foods could be interesting from a nutritional point of view due to the incorporation of unsaturated fatty acids and tocopherols/tocotrienols which are important antioxidant lipid compounds and have been associated with health-promoting effects [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

Phenolic, Nutritional and Sensory Characteristics of Bakery Foods Formulated with Grape Pomace

Antoniolli,

Becerra,

Piccoli

et al. 2024

Plants

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The potentiality of cv. Malbec grape pomace (GP) as a functional ingredient in the formulation of bakery foods (muffins, biscuits and cereal bars) was studied. The effect of GP addition on the phenolic compounds (PCs) composition, nutritional and sensory properties were evaluated. The addition of GP increased the content of dietary fiber, proteins, ash, total phenolic content (TPC), antiradical capacity (AC), anthocyanins and non-anthocyanin PCs while decreasing the carbohydrates content. The main PCs given by the GP to supplemented foods were quercetin-3-O-glucoside, rutin, caffeic acid, syringic acid and (+)-catechin. For anthocyanins, the acylated derivatives were more stable to heat treatment (baking) in food processing which was evidenced by a higher proportion of these PCs compounds when compared to the same derivatives quantified in GP. In general, when the TPC or individual concentrations of PCs were analyzed in a nutritional or functional context, one portion of the supplemented foods showed levels high enough to satisfy the recommended dose per day of these bioactive compounds. Additionally, the foods were well received by consumers during the sensory evaluation and supplemented biscuits received the highest acceptability. This study demonstrated that GP could be a viable functional ingredient in bakery foods to incorporate components like PCs and dietary fiber into traditional consumers’ diets.

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Does unsaponifiable fraction of grape seed oil attenuate nitric oxide production, oxidant and cytotoxicity activities

Cited by 13 publications

References 30 publications

SIRT 3 was involved in Lycium barbarum seed oil protection testis from oxidative stress: in vitro and in vivo analyses

SIRT 3 was involved in Lycium barbarum seed oil protection testis from oxidative stress: in vitro and in vivo analyses

Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment

Phenolic, Nutritional and Sensory Characteristics of Bakery Foods Formulated with Grape Pomace

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