Dog Allergy, a Model for Allergy Genetics

Weck, A.L. de; Mayer, Péter; Stumper, Barbara; Schiessl, B.; Pickart, Louise

doi:10.1159/000237507

Cited by 54 publications

(43 citation statements)

References 2 publications

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“…The genetics of asthma-and atopy-associated physiological traits have been studied extensively in inbred strains of experimental animals (Levitt and Mitzner 1988;deWeck et al 1997). Most studies of inbred strains and backcrosses have suggested strong genetic control of serum IgE levels (Biozzi et al 1979;Sapin et al 1984), eosinophil levels (Lammas et al 1988;Dawkins et al 1989), and airways responsiveness to cholinergic agents (Levitt and Mitzner 1988;De Sanctis et al 1995).…”

Section: Animal Modelsmentioning

confidence: 99%

Genomic Approaches to Understanding Asthma

Palmer¹,

Cookson²

2000

Genome Res.

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Asthma is the most common chronic childhood disease in developed nations, and it is a complex disease that has high social and economic costs. Asthma and its associated intermediate phenotypes are under a substantial degree of genetic control. The genetic aetiology of asthma offers a means of better understanding its pathogenesis and, thus, improving preventive strategies, diagnostic tools, and therapies. Considerable effort and expense have been expended in attempts to detect genetic loci contributing to asthma susceptibility, and extensive candidate gene studies and a number of whole-genome screens have been undertaken. This article reviews the current state of knowledge of the genetics of asthma, with a focus on genomic approaches to understanding allergic diseases.

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Section: Animal Modelsmentioning

confidence: 99%

Genomic Approaches to Understanding Asthma

Palmer¹,

Cookson²

2000

Genome Res.

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“…However, naturally-occurring asthma is very uncommon in allergic dogs [143]. In fact, the most common clinical manifestations of allergy in dogs include dermatitis, otitis, and conjunctivitis [144]. However, many naturally or actively sensitized dogs to Ascasis suum larvae or ragweed have been used as canine model for asthma [134].…”

Section: Asthmamentioning

confidence: 99%

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

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Allergic diseases have great impact on the quality of life of both people and domestic animals. They are increasing in prevalence in both animals and humans, possibly due to the changed lifestyle conditions and the decreased exposure to beneficial microorganisms. Dogs, in particular, suffer from environmental skin allergies and develop a clinical presentation which is very similar to the one of children with eczema. Thus, dogs are a very useful species to improve our understanding on the mechanisms involved in people's allergies and a natural model to study eczema. Animal models are frequently used to elucidate mechanisms of disease and to control for confounding factors which are present in studies with patients with spontaneously occurring disease and to test new therapies that can be beneficial in both species. It has been found that drugs useful in one species can also have benefits in other species highlighting the importance of a comprehensive understanding of diseases across species and the value of comparative studies. The purpose of the current article is to review allergic diseases across species and to focus on how these diseases compare to the counterpart in people.

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“…The hereditability of the development of high IgE response to immunisation has been documented in a colony of beagle dogs. In beagles, the high-IgE response ap-pears to be a dominant trait, but the development of clinical dermatitis occurs in only approximately 40% of the offspring (DeWeck, 1997;DeWeck et al, 1997). A critical aspect of high-IgE induction is that immunisation with the offending allergen had to occur shortly after birth and, if delayed until 3 to 4 months age, might be ineffective (Zunic et al, 1998).…”

Section: Genetic Factorsmentioning

confidence: 99%

Recent developments in canine atopic dermatitis: A review

Tarpataki

2006

Acta Veterinaria Hungarica

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Atopic dermatitis (AD) is a genetically predisposed inflammatory and pruritic allergic skin disease with characteristic clinical features. New results on the pathogenesis and therapeutic aspects are discussed in this review. IgE-mediated hypersensitivity may be involved in the largest subset of atopic patients, yet there is another subset for which such involvement cannot be documented. Alterations in epidermal barrier function, priming of cutaneous antigen-presenting cells with IgE, intrinsic keratinocyte defects, and development of autoimmunity are also factors that contribute to the primary disease. Polymorphisms in regions of the genome that are of key importance to the inflammatory response contribute to the patient's clinical picture. Secondary infections, especially with Staphylococcus and yeast organisms, strongly modify or augment the inflammatory response, which changes over time. After the treatment of secondary infections and skin inflammation the avoidance of causal allergens would prevent relapse. Another causative therapy is the variously effective allergen-specific immunotherapy. The newest treatments for canine AD (cyclosporin A and tacrolimus) are highly effective at suppressing the allergic response and comparable to treatment with glucocorticoids. Canine AD presents a substantial diagnostic and therapeutic challenge over a patient's lifetime, and no single treatment is universally effective.

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Dog Allergy, a Model for Allergy Genetics

Cited by 54 publications

References 2 publications

Genomic Approaches to Understanding Asthma

Genomic Approaches to Understanding Asthma

Animal Models of Allergic Diseases

Recent developments in canine atopic dermatitis: A review

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