Dog models of naturally occurring cancer

Rowell, Jennie L.; McCarthy, Donna O.; Álvarez, Carlos E.

doi:10.1016/j.molmed.2011.02.004

Cited by 344 publications

(335 citation statements)

References 68 publications

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“…This suggests that, as some previous studies have suggested, the domestic dog is an ideal model for understanding human cancer (Marconato, Gelain & Comazzi, 2013; Rowell, McCarthy & Alvarez, 2011). However, when we analyzed the specific types of neoplasia associated with death in the two species, we found significant differences.…”

Section: Discussionmentioning

confidence: 63%

The companion dog as a model for human aging and mortality

et al. 2018

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SummaryAround the world, human populations have experienced large increases in average lifespan over the last 150 years, and while individuals are living longer, they are spending more years of life with multiple chronic morbidities. Researchers have used numerous laboratory animal models to understand the biological and environmental factors that influence aging, morbidity, and longevity. However, the most commonly studied animal species, laboratory mice and rats, do not experience environmental conditions similar to those to which humans are exposed, nor do we often diagnose them with many of the naturally occurring pathologies seen in humans. Recently, the companion dog has been proposed as a powerful model to better understand the genetic and environmental determinants of morbidity and mortality in humans. However, it is not known to what extent the age‐related dynamics of morbidity, comorbidity, and mortality are shared between humans and dogs. Here, we present the first large‐scale comparison of human and canine patterns of age‐specific morbidity and mortality. We find that many chronic conditions that commonly occur in human populations (obesity, arthritis, hypothyroidism, and diabetes), and which are associated with comorbidities, are also associated with similarly high levels of comorbidity in companion dogs. We also find significant similarities in the effect of age on disease risk in humans and dogs, with neoplastic, congenital, and metabolic causes of death showing similar age trajectories between the two species. Overall, our study suggests that the companion dog may be an ideal translational model to study the many complex facets of human morbidity and mortality.

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Section: Discussionmentioning

confidence: 63%

The companion dog as a model for human aging and mortality

et al. 2018

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“…Moreover, germline mutation in the receptor tyrosine kinase MET involved in pathogenesis of canine OSA was identified mainly in Rottweilers (Liao et al 2006). It was shown that besides numerous similarities in tumor biological behavior, parallel genetic features of human and canine osteosarcoma cells also exist (Mueller et al 2007, Rowell et al 2011. So, Rottweilers can be an excellent oncologic animal model for researches on human OSA (Fenger et al 2014, Schiffman andBreen 2015).…”

Section: Discussionmentioning

confidence: 99%

The animal-dependent risk factors in canine osteosarcomas

Sapierzyński¹,

Czopowicz²

2017

Polish Journal of Veterinary Sciences

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Canine osteosarcoma (OSA) is a malignant neoplastic tumor, which develops from the primitive mesenchymal stem cell, that has or can acquire the capacity to produce neoplastic osteoid with possible neoplastic bone formation. Predisposition of some dog breeds to OSA indicates genetic background of oncogenesis. The aim of the study was to characterize animal-dependent risk factors for canine osteosarcoma development in Poland. The study was conducted on canine patients diagnosed cytologically or histopathologically as having OSA, and data on age, breed, sex, as well as tumor location and character were recorded. No sex predisposition to OSA was observed, mongrels were significantly underrepresented. Large and giant dogs accounted for 47% and 35% of all pedigree dogs, respectively, and both proved predisposed to OSA. A vast majority of OSA developed in the skeleton (appendicular skeleton was more commonly affected than axial skeleton), soft tissues were affected less often. Rottweiler dogs are strongly predisposed to OSA, suggesting that the genetic background is involved in the tumor development, and indicates that dogs of this breed are a promising object for further studies on OSA pathogenesis.

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“…Growing expectations of breeders and dog owners with regard to diagnosis and treatment encourage scientists to undertake extensive research in this area. Rowell et al (25) report that about 400 diseases in dogs and humans are analogous in the genetic background and course. Certain types of tumours, such as canine mammary carcinoma, are genetically, morphologically, clinically, and prognostically related to human tumours.…”

Section: Introductionmentioning

confidence: 99%

“…Certain types of tumours, such as canine mammary carcinoma, are genetically, morphologically, clinically, and prognostically related to human tumours. Hence, the dog is a suitable animal model for naturally occurring tumours (18,24,25,(31)(32)(33).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial D-loop mutations can be detected in sporadic malignant tumours in dogs

Ślaska

Surdyka

Brodzki³

et al. 2014

Bulletin of the Veterinary Institute in Pulawy

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The aim of this study was to identify mutations in the D-loop region of mtDNA in head, neck, and limb tumours in dogs, and determination of their relationship with the process of neoplastic transformation. Blood and tumour tissue samples from 19 dogs with diagnosed sporadic malignant tumours were analysed. DNA extraction, amplification, and sequencing of the mtDNA D-loop, and bioinformatic analyses were performed. Five mutations and 19 polymorphisms were observed in 68.42% of all tumours. Polymorphic variants were noted in 42.86% of the head and neck tumours and in 58.33% of the limb tumours. Mutations were observed in 21.05% of dogs. The mutations were found in 28.57% of the head and neck tumours and in 16.66% of the limb tumours. The mutations were identified in 50% of the studied epithelial cancers. In the mesenchymal tumours, no mutations in the D-loop region were observed. Mitochondrial haplotype A17 was found in over 40% cases of limb tumours. No association between the age, breed, sex, type of tumour, and detected polymorphic variants were observed. Different mutational changes in the D-loop sequences of mtDNA identified in the blood and tumour tissues may indicate a relationship between the type of tumour and individual changes in the D-loop nucleotide sequences of mtDNA.

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Dog models of naturally occurring cancer

Cited by 344 publications

References 68 publications

The companion dog as a model for human aging and mortality

The companion dog as a model for human aging and mortality

The animal-dependent risk factors in canine osteosarcomas

Mitochondrial D-loop mutations can be detected in sporadic malignant tumours in dogs

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