Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers

Tutino, Mauro; Granell, Raquel; Curtin, John A.; Haider, Sadia; Fontanella, Sara; Murray, Clare; Roberts, Graham; Arshad, Syed Hasan; Turner, Steve; Morris, Andrew P.; Čustović, Adnan; Simpson, Angela

doi:10.1016/j.jaci.2022.10.012

Cited by 16 publications

(13 citation statements)

References 34 publications

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“…67 Of note, in this study, the protective effect of the exposure to animal sheds was restricted to genotypes 17q12-q21, which have previously been shown to increase the risk of asthma. 67 The largest study to date of the gene-environment interaction between 17q21 locus and cat and dog ownership in infancy and wheezing illness from birth to adolescence 68 confirmed that rs2305480 risk allele (G) is associated with increased risk of asthma diagnosis, and with late-onset and persistent wheeze classes (which were derived using latent class analysis 69 ). Consistent with the results of a large meta-analysis in European children, 14 this study of 5 UK birth cohorts reported no association between early-life dog and cat ownership and asthma or any wheeze class (phenotype) in the whole population.…”

Section: Interaction Between 17q12-q21 Snps and Pet Ownership In Asth...mentioning

confidence: 95%

“…The largest study to date of the gene–environment interaction between 17q21 locus and cat and dog ownership in infancy and wheezing illness from birth to adolescence 68 confirmed that rs2305480 risk allele (G) is associated with increased risk of asthma diagnosis, and with late‐onset and persistent wheeze classes (which were derived using latent class analysis 69 ). Consistent with the results of a large meta‐analysis in European children, 14 this study of 5 UK birth cohorts reported no association between early‐life dog and cat ownership and asthma or any wheeze class (phenotype) in the whole population 68 . However, when the interaction between genotype and pet ownership was investigated, among dog owners (but not cat owners), the most replicated asthma risk allele (rs2305480_G) was no longer associated with an increased risk of asthma diagnosis or persistent wheezing 68 .…”

Section: Interactions Between Allergen Exposure and Genetics Of The Hostmentioning

confidence: 98%

“…Consistent with the results of a large meta-analysis in European children, 14 this study of 5 UK birth cohorts reported no association between early-life dog and cat ownership and asthma or any wheeze class (phenotype) in the whole population. 68 However, when the interaction between genotype and pet ownership was investigated, among dog owners (but not cat owners), the most replicated asthma risk allele (rs2305480_G) was no longer associated with an increased risk of asthma diagnosis or persistent wheezing. 68 By contrast, among those children not exposed to pets, or exposed to cats only, the risk allele was consistently associated with an increased risk of asthma and persistent wheeze.…”

Section: Interaction Between 17q12-q21 Snps and Pet Ownership In Asth...mentioning

confidence: 99%

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Environmental influences on childhood asthma: Allergens

Čustović

Moira

Murray

et al. 2023

Pediatric Allergy Immunology

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Exposure to inhalant allergens (primarily house-dust mites, cat and dog allergens) is important in the development of allergen-specific sensitization, and if asthma has developed, further allergen exposure may contribute to ongoing symptoms. However, the relationship between allergen exposure and sensitization is complex. To develop allergen-specific sensitization, one needs to be exposed to that allergen. The absence of a consistent, linear dose-response relationship between specific allergen exposures and sensitization has necessitated the application of more complex approaches to attempt to understand these inter-relationships-an essential step in would-be disease prevention. In real life, humans are simultaneously exposed to a mixture of allergens, together with a range of other

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Section: Interaction Between 17q12-q21 Snps and Pet Ownership In Asth...mentioning

confidence: 95%

Section: Interactions Between Allergen Exposure and Genetics Of The Hostmentioning

confidence: 98%

Section: Interaction Between 17q12-q21 Snps and Pet Ownership In Asth...mentioning

confidence: 99%

See 1 more Smart Citation

Environmental influences on childhood asthma: Allergens

Čustović

Moira

Murray

et al. 2023

Pediatric Allergy Immunology

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“…Indoor pet exposure during pregnancy and early childhood is associated with lower total immunoglobulin E (IgE) levels, lessened allergen sensitization, childhood wheeze and lower risk of allergic disorders including asthma 11‐21 22‐26 and contribute to variance in infant stool microbiota 27 …”

Section: Introductionmentioning

confidence: 99%

“…7,8 Indoor pet exposure during pregnancy and early childhood is associated with lower total immunoglobulin E (IgE) levels, lessened allergen sensitization, childhood wheeze and lower risk of allergic disorders including asthma. [11][12][13][14][15][16][17][18][19][20][21] Household pets, particularly dogs, influence household environmental microbes [22][23][24][25][26] and contribute to variance in infant stool microbiota. 27 These observations are consistent with potential gut microbiomerelated mechanisms linking pets to lowered risk of allergy-related disorders.…”

Section: Introductionmentioning

confidence: 99%

The impact of prenatal dog keeping on infant gut microbiota development

Panzer

Sitarik

Fadrosh

et al. 2023

Clin Experimental Allergy

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IntroductionPrenatal and early‐life dog exposure has been linked to reduced childhood allergy and asthma. A potential mechanism includes altered early immune development in response to changes in the gut microbiome among dog‐exposed infants. We thus sought to determine whether infants born into homes with indoor dog(s) exhibit altered gut microbiome development.MethodsPregnant women living in homes with dogs or in pet‐free homes were recruited in southeast Michigan. Infant stool samples were collected at intervals between 1 week and 18 months after birth and microbiome was assessed using 16S ribosomal sequencing. Perinatal maternal vaginal/rectal swabs and stool samples were sequenced from a limited number of mothers. Mixed effect adjusted models were used to assess stool microbial community trajectories comparing infants from dog‐keeping versus pet‐free homes with adjustment for relevant covariates.ResultsInfant gut microbial composition among vaginally born babies became less similar to the maternal vaginal/rectal microbiota and more similar to the maternal gut microbiota with age‐related accumulation of bacterial species with advancing age. Stool samples from dog‐exposed infants were microbially more diverse (p = .041) through age 18 months with enhanced diversity most apparent between 3 and 6 months of age. Statistically significant effects of dog exposure on β‐diversity metrics were restricted to formula‐fed children. Across the sample collection period, dog exposure was associated with Fusobacterium genera enrichment, as well as enrichment of Collinsella, Ruminococcus, Clostridaceae and Lachnospiraceae OTUs.ConclusionPrenatal/early‐life dog exposure is associated with an altered gut microbiome during infancy and supports a potential mechanism explaining lessened atopy and asthma risk. Further research directly linking specific dog‐attributable changes in the infant gut microbiome to the risk of allergic disorders is needed.

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