Doğum şeklinin yenidoğan kordon kanı hematolojik parametrelerine etkisi

Younis, Mohammed Siddig; Elgari, Mahmoud Mohamed; Mohamed, Babiker Ahmed; Idris, El Fadil Eissa

doi:10.17826/cutf.325747

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

2017

DOI: 10.17826/cutf.325747

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Doğum şeklinin yenidoğan kordon kanı hematolojik parametrelerine etkisi

Mohammed Siddig Younis¹,

Mahmoud Mohamed Elgari²,

Babiker Ahmed Mohamed³

et al.

Abstract: The aim of this study is to evaluate the influence of the mode of delivery on hematological parameters of newborns cord blood. Material and Methods: This a cross-sectional comparative study carried out at Wad Madani Teaching Maternity Hospital, Gezira State, Sudan, from July 2014 to October 2015. 400 pregnant women and their respective newborns were enrolled in the study. Blood was collected before delivery from antecubital fossa of the mothers when admitted for normal vaginal delivery or in labor for elective… Show more

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Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia

Angelo

Derbie²,

Demtse

et al. 2021

BMC Pediatr

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Background Several factors like altitude, age, sex, pregnancy, socioeconomic status, life style and race influence hematological reference interval (RIs), which are critical to support clinical decisions and to interpret laboratory data in research. Currently there are no well-established RIs for cord blood hematological parameters of newborns in Ethiopia. This study aims to generate RIs for umbilical cord blood hematological parameters of newborns from Addis Ababa, Ethiopia. Method A cross-sectional study was conducted from January 1 to March 31, 2019 on healthy, term newborns (37–42 weeks) with normal birth weight born to apparently healthy pregnant mothers who had met the eligibility criteria. From 139 newborns, 2-3ml cord blood was immediately collected from the clumped cord using EDTA tube. The samples were analyzed using Sysmex KX 21 hematology analyzer. Data was entered and the 2.5th and 97.5th percentiles (upper and lower reference limit) were determined using non parametric method by SPSS version 23. The non-parametric independent Mann-Whitney U test (Wilcoxon rank-sum test) was used to compare the distribution of the parameters between genders, modes of deliveries and gestational age. P value less than 0.05 was considered to declare statistical significance. Result The median values and 95 % reference interval for umbilical cord blood hematological parameters of newborns were as follows: WBC = 12.4 [6.6–19.4] x109/L, RBC = 4.51 [3.55–5.52] x1012/L, HGB = 15.8 [12.4–19.7] g/dL, HCT = 45.9[37.9–56.3]%, MCV = 102.1[83.9-111.6] fL, MCH = 35.3 [29.4–39.1] pg, MCHC = 34.3 [32.3–37.4] %, PLT = 236 [146–438] x109/L, LYM = 37.5 [16.6–63.0] %, MXD = 7.9[1.7–15.8] %, NEU = 53.7[30.3–78.4] %, RDW = 15.6[12.0–19.0]%, PDW = 11.0[9.1–15.7]% and MPV = 9.4[8.1–11.8] fL. The current study found no significant difference between genders, except RDW (P = 0.01), and gestational age group, but there was significant difference for WBC (p = 0.007), RBC (p = 0.018) and Absolute NEU (p = 0.001) by delivery type where newborns delivered through caesarean section had lower values for these three parameters compared to those with spontaneous delivery. Conclusions hematological reference intervals in cord blood were established for the first time from healthy newborns of Addis Ababa and its surrounding. The values are applicable for newborns from this area. Larger study throughout the country is warranted.

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Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia

Angelo

Derbie²,

Demtse

et al. 2021

BMC Pediatr

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An Indian perspective for umbilical cord blood haematological parameters reference interval

Sabnis,

Ghanghurde,

Shukla

et al. 2023

BMC Pediatr

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Background The Haematological Reference Intervals (RIs) are prone to vary on the basis of various factors such as altitude, age, sex, socioeconomic status, etc. These values play a major role in laboratory data interpretation and determine the necessary clinical treatment. Currently, India has no well–established RI for cord blood haematological parameters of newborns. This study aims to establish these intervals from Mumbai, India. Method A cross sectional study was conducted in a tertiary care hospital of India from October 2022 to December 2022 on healthy and term neonates having normal birth weight and born to healthy pregnant mothers. About 2 – 3 mL of cord blood was collected from the clamped cord into EDTA tubes from 127 term neonates. The samples were analysed in the haematology laboratory of the institute and the data was analysed. The upper and lower limits were determined using non-parametric method. The Mann–Whitney U test was used to compare the distribution of the parameters between sex of infant, modes of deliveries, maternal age and obstetric history. P value less than 0.05 was considered to declare statistical significance. Result The median values and 95% RI for umbilical cord blood haematological parameters of newborns were as follows: WBC = 12.35 [2.56–21.19] × 109/L, RBC = 4.34 [2.45–6.27] × 1012/L, HGB = 14.7 [8.08–21.44] g/dL, HCT = 48 [29–67]%, MCV = 109.6 [59.04–159.1] fL, MCH = 34.5 [30.54–37.79] pg, MCHC = 31.3 [29.87–32.75] %, PLT = 249 [16.97–479.46] × 109/L,LYM = 38 [17–62] %, NEU = 50 [26–74] %, EOS = 2.3 [0.1–4.8] %, MON = 7.3 [3.1–11.4], BAS = 0 [0–1]. This study found no statistically significant difference between sex of infants, except MCHC, and obstetric history. A significant difference was observed in WBC, EOS% and absolute NEU, LYM, MON and BAS by delivery type. A higher platelet count and absolute LYM was observed in the cord blood compared to venous blood. Conclusions For the first time, haematological reference intervals in cord blood were established for newborns in Mumbai, India. The values are applicable for newborns from this area. Larger study throughout the country is required.

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Doğum şeklinin yenidoğan kordon kanı hematolojik parametrelerine etkisi

Cited by 2 publications

References 19 publications

Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia

Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia

An Indian perspective for umbilical cord blood haematological parameters reference interval

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