Objective It is estimated that 50% to 90% of infants born with (SCA) in sub-Saharan Africa die before 5 years old. Northern Darfur State at western Sudan region has a multiethnic population with a high frequency of sickle cell anaemia, but little about it is published. This study aimed to determine the prevalence of sickle cell anaemia among children admitted to Al Fashir Teaching Hospital in Al Fashir, Northern Darfur State, Sudan. Results The prevalence of sickle cell disease by haemoglobin electrophoresis among these 400 children patients was 59 (14.8%). Sickle cell trait patients were 11.3% and Sickle cell disease positive patients were 3.5%. Individuals with SCA have consistently low blood Hb concentration, normal MCV and high mean WBC’s. Individuals with sickle cell trait had haematological parameters near to those of normal individuals.

In a prospective study, we evaluated hematological parameters in freshly obtained venous blood samples from 632 Sudanese patients attending the outpatient department at Khartoum Teaching Hospital, Khartoum, Sudan, in the period between March and July 2005. The patients were surveyed for full blood count (FBC) and hemoglobin (Hb) electrophoresis using a cellulose acetate method. Hb S [beta6(A3)Glu-->Val] was the most common abnormal Hb, which was not unexpected because the subjects live in the center of a malaria-affected area. The study showed low hematological parameters due to various causes including poor nutrition as well as infections and hemolytic processes.

A haemoglobin (Hb) disorder was the first polymorphism suggested to have a relationship with malaria, as Hb S and C offer a survival advantage in malarial endemic regions. Two schoolgirls aged 11 and 16 were admitted to the Military Hospital in Omdurman on the 2 nd of April 2009. They had Hb (haemoglobin) SC and their parents were carriers of abnormal Hb; the mother was (HbAS) and father (HbAC). These girls were the first reported cases of HbSC in Sudan. Capillary Electrophoresis (CE) was initially used to determine the Hb type. CE-High Performance Liquid Chromatography (CE-HPLC) was used as a confirmatory test. A new type of abnormal Hb in Sudan is not unexpected, because is of its wide tribal diversity. Additionally, Sudan is a high malarial region and a new Hb variant is likely to be discovered.

No abstract

No abstract