Prevalence of sickle cell disease and sickle cell trait among children admitted to Al Fashir Teaching Hospital North Darfur State, Sudan

Adam, Mudathir A.; Adam, Nassreldeen Khalid Abdelrahman; Mohamed, Babiker Ahmed

doi:10.1186/s13104-019-4682-5

Cited by 18 publications

(16 citation statements)

References 14 publications

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“…Of these participants, 70 (10.51%) were patients with sickle cell trait (Hb AS) and 13 (1.9 5%) were patients with sickle cell disease (Hb SS). These values were lower than the 11.3% of Hb AS and 3.5% of Hb SS observed in another study conducted in the same area [18] and the 44.06% among the Beja tribes in eastern Sudan [19]. In contrast, it is less than the prevalence of SCT (52%) and SCD (14%) in Meseria tribes in the south west of Kordofan [20].…”

Section: Discussionmentioning

confidence: 55%

Sickle Cell Disease and Β Globin Gene Haplotypes Among Selected Sudanese Population in North Darfur State

Adam¹,

Maki²,

Ahmed³

et al. 2021

PJMHS

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Aim: To identify β globin gene haplotypes and their frequencies in patients with SCD in North Darfur state, western Sudan Methods: This is a cross-sectional prospective community-based study that was carried out between December 2017 and August 2018. The study took place in the North Darfur state which is located in western Sudan. The study included 666 individuals (369 females and 297 males). Participants were screened for haemoglobinopathies using haemoglobin electrophoresis, while β globin haplotypes analysis for patients with SCD was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Among the 666 participants, 579 (86.94%) had normal hemoglobin (AA), while 70 (10.51%), 13 (1.95%), and 4 (0.6%) had AS, SS, and AD respectively. Cameroon haplotype was found in 42.3% of the study group. Benin was 26.9%, Bantu was 23.1% and Senegal was 7.7%. Conclusion: The Cameron haplotype was found to be most prominent in Sudanese patients, thereby confirming the findings of previous studies in the country. Keywords: sickle cell disease; anemia; β-globin; haplotype; North Darfur; Sudan

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Section: Discussionmentioning

confidence: 55%

Sickle Cell Disease and Β Globin Gene Haplotypes Among Selected Sudanese Population in North Darfur State

Adam¹,

Maki²,

Ahmed³

et al. 2021

PJMHS

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“… A significant negative correlation (a Spearman Rho of r = – 0.202 and p = 0.005 values). * References 14 15 16 17 …”

Section: Resultsmentioning

confidence: 99%

“…However, 52% of the respondents accepted such donors in the following cases: (a) after counselling about the risks involved (28%) or (b) if no alternative donor was available (24%). There was no statistically significant difference ) and negatively correlated with the prevalence of SCT in these countries (p ¼ 0.005) [14][15][16][17][18][19] (►Tables 3A and 3B).…”

Section: Sickle Cell Traitmentioning

confidence: 99%

Practice Patterns for the Acceptance of Medically Complex Living Kidney Donors with Hematuria, Sickle Cell Trait, Smoking, Illegal Drug Use, or Urological Issues: A Multinational Survey

et al. 2021

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Background To review the practice patterns for the acceptance of medically complex living kidney donors (MCLKD) among the transplant providers of the international transplant community. Methods We distributed a survey globally, through major international transplantation societies, among nephrologists and transplant surgeons (TS). The survey contained questions regarding potential donors with microscopic hematuria, sickle cell trait, renal cysts, kidney stones, smoking, or illegal drug use. Results There were 239 respondents from 29 countries, including nephrologists (42%) and TS (58%). Although most respondents would investigate microscopic hematuria, one-third of them indicated they would decline these potential donors without investigation. Interestingly, most respondents accepted heavy smokers, intermittent illegal drug users (with advice to quit), and those with incidentally identified kidney stones, remote history of renal colic or simple renal cysts. We found multiple areas of consensus in practice with some interesting differences between nephrologists and TS. Conclusions This survey highlights the practice patterns of the acceptance of MCLKDs among the international community. In the absence of clear guidelines, this survey provides additional information to counsel kidney donors with microscopic hematuria, sickle cell trait, renal cysts, kidney stones, heavy smoking, or illegal drug use.

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“…It has been reported that the mode of preparation of traditional recipes, as stipulated by the herb seller, was by decoction with clean water [8]. The experiential signi cantly higher (P < 0.05) antisickling activity of aqueous extract in this study, supports this, and it is believed that oxidative damage to cells is responsible for the activation of KCl-co-transport in sickled erythrocytes [8]. For this reason the antisickling activity of the aqueous extracts were slightly higher than the methanol extracts.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antisickling Activity of Moringa Oleifera Extracts on Sickle Cells

Omer

Yousif

Fadlalla

et al. 2020

Preprint

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Background: Sickle cell disease is one of the major haemoglobinopathies affecting African people, in Sudan many children are suffering from this disease. Numerous studies revealed that some medicinal plants have shown an antisickling activity, which may be a new therapeutic way to a range of people who are affected by this disease. Particularly that, chemical treatment is cost effective and has many side effects. The study aimed to evaluate in vitro antisickling effect of Moringa Oliefera on sickle cells.Materials and methods: Using seeds and leaves crude (methanol extract and aqueous extract), the in vitro antisickling activities of Moringa oleifera fractions, were evaluated using erythrocyte cells deoxygenated with 2% sodium metabisulphite. Normal saline was employed as an internal negative control.Results: All extracts revealed high anti sickling activity in deoxygenated erythrocytes (P < 0.05) when compared with the negative control.Conclusions: Findings from the present study suggest the antisickling potential of the seeds and leaves of Moringa oleifera.

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Prevalence of sickle cell disease and sickle cell trait among children admitted to Al Fashir Teaching Hospital North Darfur State, Sudan

Cited by 18 publications

References 14 publications

Sickle Cell Disease and Β Globin Gene Haplotypes Among Selected Sudanese Population in North Darfur State

Sickle Cell Disease and Β Globin Gene Haplotypes Among Selected Sudanese Population in North Darfur State

Practice Patterns for the Acceptance of Medically Complex Living Kidney Donors with Hematuria, Sickle Cell Trait, Smoking, Illegal Drug Use, or Urological Issues: A Multinational Survey

In Vitro Antisickling Activity of Moringa Oleifera Extracts on Sickle Cells

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