Objective It is estimated that 50% to 90% of infants born with (SCA) in sub-Saharan Africa die before 5 years old. Northern Darfur State at western Sudan region has a multiethnic population with a high frequency of sickle cell anaemia, but little about it is published. This study aimed to determine the prevalence of sickle cell anaemia among children admitted to Al Fashir Teaching Hospital in Al Fashir, Northern Darfur State, Sudan. Results The prevalence of sickle cell disease by haemoglobin electrophoresis among these 400 children patients was 59 (14.8%). Sickle cell trait patients were 11.3% and Sickle cell disease positive patients were 3.5%. Individuals with SCA have consistently low blood Hb concentration, normal MCV and high mean WBC’s. Individuals with sickle cell trait had haematological parameters near to those of normal individuals.

Background: Tinea capitis is a widespread fungal disease affecting the scalp, hair follicles, and skin underlying them. Ring worm infection is most common in children, particularly in late childhood and adolescence, as well as in immunocompromised individuals. There are no reports on the prevalence of Tinea capitis in children in Port Sudan. Objective: The aim of this study is to explore out how prevalent Tinea capitis is in school-aged children, to identify associated risk factors, to help raise public awareness about the importance of hygiene and treatment, and to mitigate infection spread. Methods: This study included a retrospective descriptive review of dermatology clinic patient reports from May 2016 to March 2018, as well as a direct interview with primary school students in Port Sudan, Red Sea State. To recognize the most susceptible age groups, genders, risk factors, and clinical manifestations. Data was collected based on clinical diagnosis by dermatologists, and children were interviewed based on laboratory diagnosis by authors using KOH of unstained scraping preparations after overnight incubation, and Tinea capitis was confirmed microscopically. Data from documents and questionnaires were manually interred and analyzed, and frequencies were measured and displayed in tables. Results: An overall prevalence of Tinea capitis was (17%) 235/1350 among the entire study population. The study showed that the disease is more in male than female with male: female ratio (4:1), and the most vulnerable age group was (4–8 years), 116/235 (49.4%), the incidence was increased by crowding [46/50,92%] the most affected neighborhoods was El Qadisiyah[62/235 (26.4%)].The commonest clinical feature was the weakness of the hair[40/50,80%]. Conclusion: There has never been a report on Tinea capitis in Port Sudan, and there are no screening services to assess the incidence. According to the findings of present study, Tinea capitis was common (17%) among children attending government-owned state primary schools in Portsudan-Red Sea State. Male gender and residing in Sudan's Red Sea climatic region were reported to be independent risk factors.

Aim: To identify β globin gene haplotypes and their frequencies in patients with SCD in North Darfur state, western Sudan Methods: This is a cross-sectional prospective community-based study that was carried out between December 2017 and August 2018. The study took place in the North Darfur state which is located in western Sudan. The study included 666 individuals (369 females and 297 males). Participants were screened for haemoglobinopathies using haemoglobin electrophoresis, while β globin haplotypes analysis for patients with SCD was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Among the 666 participants, 579 (86.94%) had normal hemoglobin (AA), while 70 (10.51%), 13 (1.95%), and 4 (0.6%) had AS, SS, and AD respectively. Cameroon haplotype was found in 42.3% of the study group. Benin was 26.9%, Bantu was 23.1% and Senegal was 7.7%. Conclusion: The Cameron haplotype was found to be most prominent in Sudanese patients, thereby confirming the findings of previous studies in the country. Keywords: sickle cell disease; anemia; β-globin; haplotype; North Darfur; Sudan

Objective: A variety of observations of the hemoglobin D (Hgb D) phenotype has occurred in association with family studies of patients with sickle cell disease. Very little is known about the occurrence and prevalence of the Hgb D variant and its impact on blood profiles among Sudanese. This study was aimed at determining the percentage of Hb D in North Darfur State, West Sudan, whose population has been shown to have hemoglobin-S (Hb S) disease. Methods: From December 2017 to August 2018, this descriptive community-based investigation was conducted. Six hundred and sixty-six (666) people were randomly selected to participate in this study. With each participant's there was verbal consent. A questionnaire was designed to collect personal details. 5 mL of venous blood was gathered in EDTA containers. The Hb D variant was checked using Sebia Minicap Automated Capillary Electrophoresis System- USA and frequency was calculated using version 21.0 of the software package for social science (SPSS). Result: The prevalence of Hb variants was as follows: AD=0.6%, SS=2%, AS=10.5 %, and AA=86.9%. Conclusion: The prevalence of Hb D variant was 4 (0.6 %) in 666 participants from four western Sudanese tribes, beside reported of Hb SS and Hb AS.