Domain structure of erythrocyte membranes in psoriasis: an EPR study

Górnicki, Albert

doi:10.1016/s0923-1811(02)00037-3

Cited by 7 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[12,37,38] In recent years, an association of psoriasis with overweight obesity has been proposed [15] that might lead to enhanced inflammation and an increase in cardiovascular co-morbidities. Moreover, the number of circulating erythrocytes would also be expected to increase, to perfuse a higher body mass.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have reported erythrocyte membrane changes in psoriasis, namely, in membrane lipid peroxidation, [37,38] in the sodium-potassium adenosine triphosphatase pump, [39] in the binding of cyclic adenosine monophosphate to protein kinase A, [40] and in the expression and distribution of membrane protein 4.1. [41] Previous studies in our laboratory [12] showed that leukocyte activation seems to induce, especially in the active forms of psoriasis, an altered erythrocyte band 3 profile, similar to that observed in older and or damaged erythrocytes; we also observed a lower RBC count accompanied by changes suggesting a slight increase in RBC removal and RBC production.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Erythroid Disturbances Before and After Treatment of Portuguese Psoriasis Vulgaris Patients

Coimbra

Oliveira²,

Reis

et al. 2012

American Journal of Clinical Dermatology

View full text Add to dashboard Cite

Our data suggest that psoriasis vulgaris triggers an inflammatory response, with release of acute-phase reactants, reactive oxygen species, cationic proteins, and proteases, leading to enhanced RBC damage/aging and, ultimately, to enhanced RBC removal. These assumptions were strengthened by the observation that, with treatment, all of these changes were reversed, the inflammation was reduced, the production of reticulocytes was increased, and the RBCs presented changes usually observed in younger/less damaged RBCs. These erythroid changes were enhanced with PUVA therapy, probably due to the more pronounced clearing of the lesions, as suggested by Psoriasis Area and Severity Index (PASI) scores. Finally, after treatment, a residual inflammation still persisted that might contribute to the observed erythroid disturbances.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Erythroid Disturbances Before and After Treatment of Portuguese Psoriasis Vulgaris Patients

Coimbra

Oliveira²,

Reis

et al. 2012

American Journal of Clinical Dermatology

View full text Add to dashboard Cite

show abstract

“…Several markers of oxidative stress have been studied in psoriatic RBCs, namely the activity of antioxidant enzymes, membrane lipid peroxidation and membrane fluidity. Recently, changes in the domain structure of those RBCs, namely in the portion of the most ordered domain, were also reported as potential markers of oxidative RBC damage, and additionally as markers for the activity of psoriasis 20,21 …”

mentioning

confidence: 99%

Erythrocyte damage in mild and severe psoriasis

et al. 2004

View full text Add to dashboard Cite

SummaryBackground Psoriasis is a common chronic and recurrent inflammatory skin disorder. Oxygen metabolites and proteases released by activated inflammatory cells may induce oxidative and proteolytic damage to plasma constituents and red blood cells (RBCs). RBCs have a limited biosynthesis capacity and poor repair mechanisms. Objectives To study RBCs as a potential cumulative marker of oxidative and proteolytic stress in psoriasis, and as a marker of worsening of the disease. Methods The study was performed in 70 patients with mild or severe psoriasis and in 40 control individuals. We evaluated total and differential leucocyte count and, as markers of leucocyte activation, plasma elastase and lactoferrin. Besides the basic RBC study (RBC count, haematocrit, haemoglobin concentration and haematimetric indices) we evaluated antioxidant defences (catalase, superoxide dismutase, glutathione peroxidase and selenium), osmotic fragility and reticulocyte count; in the RBC membrane we evaluated lipid peroxidation and susceptibility to lipid peroxidation, membrane fluidity, levels of cholesterol and phospholipids, membrane-bound haemoglobin, band 3 profile and levels of vitamin E; serum levels of bilirubin, total plasma antioxidant capacity, lipid profile and lipid peroxidation were also evaluated. Results Psoriasis patients showed a rise in leucocytes, mainly neutrophils, which was associated with a rise in elastase and lactoferrin. Patients had a reduced RBC count, antioxidant defences and membrane fluidity, elevated membrane lipid peroxidation, membrane-bound haemoglobin, osmotic fragility and reticulocyte count, and a different band 3 profile. Most of these modifications were enhanced in severe psoriasis. Conclusions In summary, our data show that the RBCs are at a lower number in psoriasis patients, and present several changes denoting an enhanced damage and ⁄ or ageing process, which seem to be strongly connected with neutrophil activation, oxidative stress and worsening of psoriasis.

show abstract

“…Ordinarily, the lesion is encountered on the scalp; but wrist, elbow, mons pubis, vulva, buttock, and chest are other locations where it can be found. Duration of lesion ranges between 4 to 50 years in the literature [6]. …”

Section: Discussionmentioning

confidence: 99%

Posttraumatic proliferating trichilemmal tumour on the frontal region of the scalp: a case report

Şengül

2010

Cases Journal

View full text Add to dashboard Cite

IntroductionProliferating trichilemmal tumour defined with more than one terms by many author, after well documentated series reported as "proliferating epidermoid cysts" by Wilson-Jones, firstly in 1966. They are rare, slowly growing, lobular masses inherited autosomal dominantly and localized on scalps of older women and believed to arising as a complication of a trauma and inflammation and effect 5-10% of people.Case presentationWe intented to present the case of a 62 years old Turkish woman with a history of slowly growing scalp mass after the trauma, especially during last 15 years. After surgical evaluation, histopathological slides exhibited the characteristic structures of proliferating trichilemmal tumour. The patient was lost to follow-up and no recurrens or distance metastasis detected during 40 months follow-up.ConclusionIn our opinion, widely surgical excision with long-term surveillance is the best choice for both diagnosis and treatment still today.

show abstract

Domain structure of erythrocyte membranes in psoriasis: an EPR study

Cited by 7 publications

References 31 publications

Erythroid Disturbances Before and After Treatment of Portuguese Psoriasis Vulgaris Patients

Erythroid Disturbances Before and After Treatment of Portuguese Psoriasis Vulgaris Patients

Erythrocyte damage in mild and severe psoriasis

Posttraumatic proliferating trichilemmal tumour on the frontal region of the scalp: a case report

Contact Info

Product

Resources

About