The intensification of pig production is considered a risky activity for the environment when the generated pig slurry is not adequately treated. In addition, intensive agriculture practices where pig slurry is applied to the cropland could cause nitrate leaching, salinization, and soil pollution (heavy metals and pathogens), thus the development of an eco-friendly system for pig slurry treatment is essential to avoid undesirable environmental impacts. The main objective of this study was to assess the efficiency of an integrated purification system (IPS) for treating pig slurry. The system included a pretreatment module (raw pig slurry tank, phase separator, aeration tank, and settlement tank), constructed wetlands (CWs) that included an unplanted cell and a planted cell, and a storage pond (SP). Pig slurry samples from the pretreatment modules, CWs, and SP were collected in triplicate and physic-chemical and microbial analyses were performed. Results showed that the pretreatment modules decreased the total suspended solids (TSS), total nitrogen (TN), and total phosphorus (TP) concentrations in the liquid fraction. Higher total nitrogen removal was reported in the planted cell, which decreased from 4.0 g L−1 to 1.9 g L−1 in the inflow and outflow, respectively. Total efficiencies over 85% were found in the planted and unplanted cells for TSS, Kjeldahl nitrogen (KN), chemical oxygen demand (COD), and TP. Microbial parameters were eliminated after the treatment in the planted cell. Therefore, the results indicated that filtration (pretreatment), purification (constructed wetland), and bioremediation (storage pond) constituted an appropriate IPS for treating pig slurry.