Domino Cyclization Initiated by Cross‐Rauhut–Currier Reactions

Abstract

The Rauhut–Currier reaction has proved itself as a promising strategy for synthesis of multifunctionalized molecules, although still being in its infancy with regard to limitations of selectivity and scope. Considerable attention has thus been devoted to resolution of difficulties associated with controlling strategies and enantioselectivity. Carbocycles with distinct structural frameworks can be assembled rapidly through incorporation of cross‐Rauhut–Currier reactions into domino processes. The fine compatibility and widespread utility of Rauhut–Currier reactions is illustrated with several recent outstanding examples, with the aim of shedding light on the design of new substrates and catalysts for syntheses of complex molecules.

Advances in nucleophilic phosphine catalysis of alkenes, allenes, alkynes, and MBHADs

“…For detailed account of the Morita reaction, the reader should consult several reviews. 6 For the RC reaction, the reader should refer to Miller’s review. 7 …”

Phosphine‐Initiated Domino Reaction: A Convenient Method for the Preparation of Spirocyclopentanones

“…[4] In the past decades, phosphine-catalyzed domino reactions [5] have become a powerful tool in the construction of carbo-and heterocycles. [6] While electron-deficient alkenes [7] and alkynes [8] have been well studied, little attention has been paid to ynone derivatives in organocatalytic domino reactions. [9] Recently, Tomita and Fu reported elegant intramolecular cycloaddition reactions.…”

Intramolecular Baylis-Hillman reaction: synthesis of heterocyclic molecules

“…)-electrophiles (aldehydes / ketones /α-keto-esters / aldimines / epoxides / halides etc.) systems (2) activated alkene-activated alkene (Rauhut-Currier reaction) [31][32][33][34] system.…”