Domoic acid depuration by intertidal bivalves fed on toxin-producing Pseudo-nitzschia multiseries

Jennings, Eva Dusek; Parker, Micaela S.; Simenstad, Charles A.

doi:10.1016/j.toxcx.2020.100027

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…The observed detoxification rates were lower than expected from laboratory experiments. M. galloprovincialis has been shown to depurate DA at a rate of 0.4-0.58 day −1 [22], R. philippinarum at 0.44 day −1 [88], and P. rhomboides and V. corrugata at 0.49 and 0.75 day −1 , respectively (unpublished data). These differences may be due to some uptake of DA during the depuration phase, which reduces the apparent depuration speed.…”

Section: Intoxication and Detoxification Velocitymentioning

confidence: 88%

Twenty-Five Years of Domoic Acid Monitoring in Galicia (NW Spain): Spatial, Temporal and Interspecific Variations

Blanco

Moroño

Arévalo

et al. 2021

Toxins

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Prevalence, impact on shellfish resources and interspecific, spatial, and temporal variabilities of domoic acid (DA) in bivalves from Galicia (NW Spain) have been studied based on more than 25 years of monitoring data. The maximum prevalence (samples in which DA was detected) (100%) and incidence (samples with DA levels above the regulatory limit) (97.4%) were recorded in Pecten maximus, and the minimum ones in Mytilus galloprovincialis (12.6 and 1.1%, respectively). The maximum DA concentrations were 663.9 mg kg−1 in P. maximus and 316 mg kg−1 in Venerupis corrugata. After excluding scallop P. maximus data, DA was found (prevalence) in 13.3% of bivalve samples, with 1.3% being over the regulatory limit. In general, the prevalence of this toxin decreased towards the North but not the magnitude of its episodes. The seasonal distribution was characterized by two maxima, in spring and autumn, with the later decreasing in intensity towards the north. DA levels decreased slightly over the studied period, although this decreasing trend was not linear. A cyclic pattern was observed in the interannual variability, with cycles of 4 and 11 years. Intoxication and detoxification rates were slower than those expected from laboratory experiments, suggesting the supply of DA during these phases plays an important role.

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Section: Intoxication and Detoxification Velocitymentioning

confidence: 88%

Twenty-Five Years of Domoic Acid Monitoring in Galicia (NW Spain): Spatial, Temporal and Interspecific Variations

Blanco

Moroño

Arévalo

et al. 2021

Toxins

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“…Indeed, suspension-feeding invertebrates are capable of ingesting toxic Pseudo-nitzschia cells leading to high amounts of DA accumulated in their tissues (Basti et al, 2018;Dusek Jennings et al, 2020) seriously threatening human health through contaminated seafood consumption (Pulido, 2008;La Barre et al, 2014). Over the last two decades, these blooms have caused numerous and persistent harvest closures for some economically important species (Amzil et al, 2001;Husson et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Notwithstanding, profound inter-specific variability in the toxicokinetics of accumulation and depuration rates of DA burdens have been reported between several invertebrate species in the same affected area (Costa et al, 2004(Costa et al, , 2005aBogan et al, 2007a,b,c;Lage et al, 2012;Ben haddouch et al, 2016;Dusek Jennings et al, 2020;Blanco et al, 2021;Kvrgić et al, 2022). Thus, invertebrates have been broadly classified as "fast" or "slow" DA-depurators (Blanco et al, 2002a,b;Basti et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, invertebrates have been broadly classified as "fast" or "slow" DA-depurators (Blanco et al, 2002a,b;Basti et al, 2018). Larger scallops, such as King scallops Pecten maximus (Blanco et al, 2002a;García-Corona et al, 2022) and giant scallops Placopecten magellanicus (Gilgan, 1990;Haya et al, 1991), some big-clams, such as razor clams Siliqua patula (Horner et al, 1993;Dusek Jennings et al, 2020), and some cephalopod mollusk such as Octopus vulgaris (Costa et al, 2004) and Eledone moschata (Costa et al, 2005b) as well as the common cuttlefish Sepia officinalis (Costa et al, 2005a;Ben haddouch et al, 2015) are capable of accumulating high amounts of DA, principally in the digestive gland, and require from many months to a couple of years to depurate the toxin from their tissues. Therefore, these species have been considered as slow DA-depurators.…”

Section: Introductionmentioning

confidence: 99%

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Comparative study of domoic acid accumulation, isomer content and associated digestive subcellular processes in five marine invertebrate species

García-Corona,

Hegaret,

Lassudrie

et al. 2024

Aquatic Toxicology

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“…In bivalve tissues, the accumulation process depends on several factors, such as the presence and ingestion of toxic Pseudo-nitzschia species, the cell toxin content [4], as well as the balance of the physiological mechanisms regulating DA accumulation and depuration [12][13][14][15]. Depuration is the main process regulating maximal DA concentrations in shellfish and how long after the shellfish have ceased feeding on toxic phytoplankton before they are safe for human consumption [13,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Rapid Domoic Acid Depuration in the Scallop Argopecten purpuratus and Its Transfer from the Digestive Gland to Other Organs

Álvarez

Rengel

Araya

et al. 2020

Toxins

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Domoic acid (DA), the main toxin responsible for Amnesic Shellfish Poisoning, frequently affects the marine resources of Chile and other countries across the South Pacific, thus becoming a risk for human health. One of the affected resources is the scallop Argopecten purpuratus. Even though this species has a high commercial importance in Northern Chile and Peru, the characteristics of its DA depuration are not known. In this work, the DA depuration was studied by means of two experiments: one in controlled (laboratory) and another in natural conditions. All organs of A. purpuratus depurated the toxin very quickly in both experiments. In some organs, an increase or a very small decrease of toxin was detected in the early depuration steps. Several models were used to describe this kinetics. The one that included toxin transfer between organs and independent depuration from each organ was the model that best fit the data. It seems, therefore, that the DA in this species is quickly transferred from the digestive gland to all other organs, which release it into the environment. Physiological differences in the two experiments have been shown to have some effect on the depuration from each organ but the actual reasons are still unknown.

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Domoic acid depuration by intertidal bivalves fed on toxin-producing Pseudo-nitzschia multiseries

Cited by 9 publications

References 25 publications

Twenty-Five Years of Domoic Acid Monitoring in Galicia (NW Spain): Spatial, Temporal and Interspecific Variations

Twenty-Five Years of Domoic Acid Monitoring in Galicia (NW Spain): Spatial, Temporal and Interspecific Variations

Comparative study of domoic acid accumulation, isomer content and associated digestive subcellular processes in five marine invertebrate species

Rapid Domoic Acid Depuration in the Scallop Argopecten purpuratus and Its Transfer from the Digestive Gland to Other Organs

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