Domperidone in the Treatment of Postoperatve Vomiting

Zegveld, C; Smits, Josien; Knape, H; Stockman, A.; Gallant, Joel E.; Caron, Dania; Boghaert, A; Belopavlovic, M.

doi:10.1213/00000539-197811000-00019

Cited by 14 publications

(5 citation statements)

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“…Postoperative emesis continues to pose problems for surgical patients, and some studies report an incidence as high as 60:/, (1). In spite of numerous studies (2)(3)(4)(5)(6)(7)(8)(9), the ideal pharmacological agent for the prevention of postoperative emetic symptoms has yet to be found. Recent studies report, however, that transdermal scopolamine is effective against seasickness (10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

Double–blind comparison of transdermal scopolamine, droperidol and placebo against postoperative nausea and vomiting

Tigerstedt

Salmela

Aromaa

1988

Acta Anaesthesiol Scand

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Since transdermal scopolamine (TS) seems effective against seasickness, we compared its antiemetic effect with intravenous droperidol (DHBP), our routine antidote for postoperative emesis. Ninety-six female patients (ASA I-II) scheduled for short-stay surgery were randomly allocated to three study groups after giving their informed consent. The three groups were as follows: TS adhesive, delivering 140 micrograms initially and 5 micrograms/h thereafter + placebo 0.5 ml i.v. 5 min before the end of surgery; transdermal placebo adhesive preoperatively + DHBP 0.5 ml (1.25 mg) i.v. 5 min before the end of surgery; transdermal placebo + 0.5 ml placebo i.v. as indicated above. Oxycodone i.m. and glycopyrrolate i.v. were given for premedication together with the test adhesive. Anaesthesia was induced with thiopental and maintained with nitrous oxide and oxygen, enflurane, vecuronium and fentanyl. Neostigmine and glycopyrrolate were administered for reversal. In the recovery room no differences in nausea or vomiting were observed between the groups. Sedation was significantly more marked (P less than 0.15-0.0001) after DHBP than after either TS or the given DHBP and 6% of those given the placebo (P less than 0.05). During the following 24 h nausea was reported more by the placebo patients (25) than by those on TS (20) or DHBP (15) (P less than 0.05). However, actual vomiting on the ward did not differ between the groups. Visual disturbances were more frequent after TS (P less than 0.01). We conclude that prophylactic transdermal scopolamine does not diminish postoperative emetic sequelae.

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mentioning

confidence: 99%

Double–blind comparison of transdermal scopolamine, droperidol and placebo against postoperative nausea and vomiting

Tigerstedt

Salmela

Aromaa

1988

Acta Anaesthesiol Scand

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“…uron and Leysen, 1978;Michiels, Hendriks and Heykants, 1981). Some studies have suggested that it is effective in the treatment of postoperative nausea and vomiting (Fragen and Caldwell, 1978;Helmers and van Leeuwen, 1979;Zegfeld et al, 1978); however, in others it has been shown to be ineffective in this situation (Wilson and Dundee, 1979).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Use of Domperidone, Droperidol and Metoclopramide in the Prevention of Nausea and Vomiting Following Gynaecological Surgery in Day Cases

Madej

Simpson

1986

British Journal of Anaesthesia

104

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The efficacy of domperidone 20 mg, droperidol 2.5 mg, metoclopramide 10 mg or placebo (saline) administered i.v. before induction of anaesthesia, was studied in 199 women undergoing gynaecological surgery as day cases. Following a standardized general anaesthetic technique, droperidol or metoclopramide significantly reduced the incidence of nausea and vomiting; domperidone decreased the incidence of postoperative nausea alone. The occurrence of extrapyramidal reactions was similar in all groups. Patients treated with antiemetics were no more sedated than those given placebo. Those receiving droperidol complained of significantly less postoperative pain than those who had received domperidone or metoclopramide.

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“…Several studies reported that Domperidone was superior to placebo when used as an antiemetic agent to treat acute conditions such as gastroenteritis, postoperative emesis, and drug-induced nausea and vomiting, mainly with antiparkinsonism dopamine agonists. [ 6 7 8 9 10 11 12 ] Additionally, Domperidone has been used, as a prokinetic agent, to treat gastroesophageal reflux disease (GERD), dyspepsia, and gastroparesis and several studies have confirmed its efficacy in these clinical contexts. [ 13 14 15 16 17 18 19 20 21 ] Domperidone has also been found to be as equally effective as metoclopramide, another prokinetic agent, but with less reported side effects.…”

Section: Drug Efficacymentioning

confidence: 99%

Saudi gastroenterology association position statement on safety issues associated with the use of domperidone

Mosli

Al-Judaıbı

Almadi

2014

Saudi J Gastroenterol

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Domperidone in the Treatment of Postoperatve Vomiting

Cited by 14 publications

References 0 publications

Double–blind comparison of transdermal scopolamine, droperidol and placebo against postoperative nausea and vomiting

Double–blind comparison of transdermal scopolamine, droperidol and placebo against postoperative nausea and vomiting

Comparison of the Use of Domperidone, Droperidol and Metoclopramide in the Prevention of Nausea and Vomiting Following Gynaecological Surgery in Day Cases

Saudi gastroenterology association position statement on safety issues associated with the use of domperidone

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