Donation after cardiac death for lung transplantation

Mortality on the Waiting List for Lung Transplantation in Patients with Idiopathic Pulmonary Fibrosis: A Single-Centre Experience

“…In our Country, donation is actually not able to meet the demands (19.3 donors per million of population in 2014) [16]. Great expectancy is placed on ex vivo lung perfusion (EVLP) techniques and donation after cardiac death (DCD) to expand pool of donors [17,18]; however, at the moment, these kinds of programms are still not widely available.…”

Lung Quality and Utilization in Controlled Donation After Circulatory Determination of Death Within the United States

“…Expanding the number of donor lung organs through the use of controlled donation after circulatory determination of death (cDCDD) has the potential to improve this disparity while preserving long-term recipient outcomes (3)(4)(5)(6). Multiple U.S. (7)(8)(9)(10)(11)(12) and international (13)(14)(15)(16)(17)(18)(19)(20) studies have demonstrated comparable to favorable survival among cDCDD lung recipients compared with donation after neurological determination of death (DNDD) lung recipients.…”

"Strategies to improve the diagnosis and treatment of ischemia-reperfusion injury after lung transplantation"

“…[3,4] Compared with other types of solid organ transplantation, lung transplantation has the lowest median survival (Figure 1). [3][4][5] Despite these shortcomings, more lung transplant recipients are alive in the US (11,486 as of June 2014) than at any other time since the inception of lung transplantation in 1963. [4] Figure 1: Waitlist and transplant median survival for solid organ transplants in the United States.…”

“…[8][9][10] Even with inclusion of DCD lungs in transplant protocols, overall utilization remains low, and the supply of acceptable organs has not fulfilled the ever-increasing demand. [11,12] Currently, DCD lungs are used in less than 2% of lung transplants per year due to the increased risk of PGD. [3] PGD, which typically results from severe IRI, is a clinical diagnosis that describes acute lung injury that occurs within the early postoperative period (72 hours) after lung transplantation and is characterized by reduced oxygenation capacity and progressive lung failure.…”

“…overall utilization remains low, and the supply of acceptable organs has not fulfilled the everincreasing demand. [11,12] Uncontrolled DCD lungs (Maastricht categories I and II) are an additional source of available organs but are currently not utilized for transplantation in the United States. [11,54] There are several reasons for this, including ethical concerns, logistical barriers, and graft function uncertainty.…”