Donation of embryos for stem cell research--how many couples consent?: Short communication

Bjuresten, Kerstin

doi:10.1093/humrep/deg265

Cited by 64 publications

(53 citation statements)

References 8 publications

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“…The average in vitro development rates of assisted reproductive technologies oocytes following either in vitro fertilization and/or intracytoplasmic sperm injection was 76% for normal fertilization (two pronuclei) and 92% for cleavage to good-quality embryos (grades I and II) determined on days 2-4 (data not shown). Since a significant percentage of couples undergoing fertility treatments appear willing to participate in this type of research [28,29], we believe that the method described to obtain donated oocytes is a viable and ethically acceptable strategy that can enable optimization of the nuclear transfer stem cell method to produce embryonic stem cells [10]. Although it allows the acquisition of only limited numbers of oocytes and thus small groups of embryos from an individual egg donor, it clearly is a more efficacious process than those in previous studies, which obtained oocytes predominantly from patients of increasing maternal ages undergoing a variety of IVF treatments [15,24].…”

Section: Discussionmentioning

confidence: 99%

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Development of Human Cloned Blastocysts Following Somatic Cell Nuclear Transfer with Adult Fibroblasts

French¹,

et al. 2008

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Nuclear transfer stem cells hold considerable promise in the field of regenerative medicine and cell-based drug discovery. In this study, a total of 29 oocytes were obtained from three young (20 -24 years old) reproductive egg donors who had been successful in previous cycles. These oocytes, deemed by intended parents to be in excess of their reproductive needs, were donated for research without financial compensation by both the egg donor and intended parents after receiving informed consent. All intended parents successfully achieved ongoing pregnancies with the oocytes retained for reproductive purposes. Mature oocytes, obtained within 2 hours following transvaginal aspiration, were enucleated using one of two methods, extrusion or aspiration, after 45 minutes of incubation in cytochalasin B. Rates of oocyte lysis or degeneration did not differ between the two methods. Somatic cell nuclear transfer (SCNT) embryos were constructed using two established adult male fibroblast lines of normal karyotype. High rates of pronuclear formation (66%), early cleavage (47%), and blastocyst (23%) development were observed following incubation in standard in vitro fertilization culture media. One cloned blastocyst was confirmed by DNA and mitochondrial DNA fingerprinting analyses, and DNA fingerprinting of two other cloned blastocysts indicated that they were also generated by SCNT. Blastocysts were also obtained from a limited number of parthenogenetically activated oocytes. This study demonstrates, for the first time, that SCNT can produce human blastocyst-stage embryos using nuclei obtained from differentiated adult cells and provides new information on methods that may be needed for a higher level of efficiency for human nuclear transfer. STEM CELLS 2008;26:485-493 Disclosure of potential conflicts of interest is found at the end of this article.

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Section: Discussionmentioning

confidence: 99%

“…Typically, intended parents elected to donate those oocytes in excess of 10 -12 per transvaginal aspiration [28,29].…”

Section: Oocyte Donationmentioning

confidence: 99%

Development of Human Cloned Blastocysts Following Somatic Cell Nuclear Transfer with Adult Fibroblasts

French¹,

et al. 2008

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“…There is a growing literature on embryo donation in which such dynamics have begun to be explored (see Bangsbol et al, 2004;Bjuresten and Hovatta, 2003;Burton and Sanders, 2004;CHILD, 2002;Choudhary et al, 2004;Newton et al, 2003;Kovacs et al, 2003;Laurelle and Englert, 1995;Lornage et al, 1995;McMahon et al, 2003;Moutel et al, 2002;Soderstrom-Antilla et al, 2001;Svanberg et al, 2001;Van Voorhuis et al, 1999;Westlander et al, 1998; on the ethical dimensions see Magnus and Cho, 2005;Robertson, 1995).…”

mentioning

confidence: 99%

Embryonic Economies: The Double Reproductive Value of Stem Cells

Franklin¹

2006

BioSocieties

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“…Ainda que alguns países prevejam a assinatura do consentimento antes do primeiro tratamento 40 , durante o tratamento 41 ou após a conclusão do tratamento 42 , não existe estandardização deste procedimento entre países, e a legislação é omissa a este respeito em Portugal. Na definição desses momentos, importa considerar as trajetórias reprodutivas dos casais e proporcionar-lhes tempo para refletirem sobre as decisões a tomar.…”

Section: Discussionunclassified

Consentir na criopreservação de embriões: perceção de casais usuários de medicina da reprodução

Silva

Samorinha

Alves

et al. 2017

Interface (Botucatu)

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Este estudo qualitativo analisou as perceções de casais quanto aos fatores que contextualizam o consentimento livre e esclarecido na criopreservação de embriões, a partir de 34 entrevistas semiestruturadas, em Portugal. Analisaram-se os dados segundo os princípios da grounded theory. Dos resultados emergiram as seguintes necessidades: provisão de informações detalhadas, rigorosas, coerentes e no tempo adequado sobre os custos e duração da criopreservação e o destino dos embriões; reforço da privacidade física; tempo para refletir sobre o destino dos embriões e a divulgação da identidade dos beneficiários. As condições de aplicação do consentimento parecem ameaçar três dos seus elementos fundamentais: informação, voluntarismo e ponderação. Importa desenvolver orientações ético-profissionais que assegurem um consentimento assente em práticas de aconselhamento e prestação de informação adequadas às necessidades e expectativas dos pacientes. This qualitative study analyzed couples' perceptions about the factors that contextualize informed consent regarding embryo cryopreservation, through 34 semi-structured interviews, in Portugal. Data were analyzed according to the principles of grounded theory. The results revealed the following needs: timely provision of detailed, accurate and intelligible information about the costs of cryopreservation, embryo storage limit and embryo disposition; reinforcement of physical privacy; availability of time to reflect about embryo disposition and disclosure of users' identities. The conditions of administration of the informed consent appear to threaten three of its fundamental elements: information, voluntarism and reflection. The development of professional and ethical guidelines is necessary to ensure the implementation of a consent process characterized by practices of counseling and information adapted to patients' needs and expectations.

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Donation of embryos for stem cell research--how many couples consent?: Short communication

Abstract: A high proportion, 92%, of couples who underwent infertility treatment in Sweden preferred donating their supernumerary embryos for stem cell research rather than letting them be discarded.

Cited by 64 publications

References 8 publications

Development of Human Cloned Blastocysts Following Somatic Cell Nuclear Transfer with Adult Fibroblasts

Development of Human Cloned Blastocysts Following Somatic Cell Nuclear Transfer with Adult Fibroblasts

Embryonic Economies: The Double Reproductive Value of Stem Cells

Consentir na criopreservação de embriões: perceção de casais usuários de medicina da reprodução

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