Donation of fresh oocytes for nuclear transfer research – a new approach

Choudhary, Meenakshi; Nesbitt, M; Leary, Christine; Murdoch, AP

doi:10.1016/s1472-6483(10)60630-x

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…We asked women undergoing superovulation for IVF treatment to donate two of their oocytes if 12 or more were aspirated. We estimated that this would not reduce the pregnancy rate and this resulted in the donation of 66 fresh oocytes to our research within 7 months 4 . Although this was an improvement, these numbers are not sufficient to permit rapid progress in this field.…”

Section: Obtaining a Supply Of Oocytesmentioning

confidence: 97%

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Cloning

Murdoch¹

2007

The Obstetric & Gynaecologis

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Key content Reproductive cloning is prohibited in the United Kingdom and there is legislation banning it in some other countries. The therapeutic potential of being able to grow unlimited supplies of functioning, differentiated cells of different types is immense. One possible application in gynaecology might be to use cell‐based therapies to replace the endometrium and to treat myometrial scars and bladder wall or vaginal deficiencies. A licence to undertake somatic cell nuclear transfer for the derivation of stem cells was granted in the UK in 2004 and the first blastocyst described in 2005. One potential way of obtaining oocytes might be to ask women undergoing in vitro fertilisation to donate some of theirs. Learning objectives To learn about the moral and ethical issues surrounding human cloning. To be aware of the potential use of cloning in gynaecology. To be informed about the current research. Ethical issues How can oocytes be obtained without risk to the donor? Is it ethical to pay women to donate oocytes? Please cite this article as: Murdoch A. Cloning. The Obstetrician & Gynaecologist 2007;9:177–180.

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Section: Obtaining a Supply Of Oocytesmentioning

confidence: 97%

“…We estimated that this would not reduce the pregnancy rate and this resulted in the donation of 66 fresh oocytes to our research within 7 months. 4 Although this was an improvement, these numbers are not sufficient to permit rapid progress in this field.…”

Section: Obtaining a Supply Of Oocytesmentioning

confidence: 99%

Cloning

Murdoch¹

2007

The Obstetric & Gynaecologis

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“…SCNT works best on eggs freshly removed from a woman's body. But Murdoch and colleagues found that, even if they convinced in vitro fertilization patients to donate spare eggs, they could only garner a grand total from all the patients of about 10 eggs per month (Choudhary, et al, 2006). The Harvard team plans to solicit egg donations from young, healthy women.…”

Section: Mergers and Acquisitionsmentioning

confidence: 99%